BCSCDB: Biomarkers of Cancer Stem Cells Database
Number of interactions with PANC-1 is 67
| INTERACTOR1 | INT1_HGNC_ID | INTERACTOR2 | INT2_HGNC_ID | INTERACTION_TYPE | CSC_METHOD | CANCER_TYPE | HISTOLOGICAL_TYPE | CELL_LINE | INTERACTION_METHOD | EXPRESSION_LEVEL | PUBMED_ID |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SMAD4 | 6770 | ALDH1A1 | 402 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of SMAD4 followed by qRT-PCR | Up | 25769430 |
| SMO | 11119 | CDH1 | 1748 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated kncokdown of SMO followed by RT-PCR | Up | 26918054 |
| FOXM1 | 3818 | SOX2 | 11195 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | Stable expression of FOXM1 by Luciferase Reporter assay followed by RT-PCR | Up | 28802012 |
| SATB2 | 21637 | XIAP | 592 | Protein-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | ChIP assay | NA | 27472393 |
| SATB2 | 21637 | BCL2 | 990 | Protein-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | ChIP assay | NA | 27472393 |
| SKI | 10896 | GLI2 | 4318 | Protein-Protein Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | Co-IP assay | NA | 27734340 |
| SATB2 | 21637 | HOXA2 | 5103 | Protein-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | ChIP assay | NA | 27472393 |
| SATB2 | 21637 | IBSP | 5341 | Protein-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | ChIP assay | NA | 27472393 |
| SATB2 | 21637 | KLF4 | 6348 | Protein-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | ChIP assay | NA | 27472393 |
| SATB2 | 21637 | MYC | 7553 | Protein-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | ChIP assay | NA | 27472393 |
| HOTTIP | 37461 | WDR5 | 12757 | RNA-Protein Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | RIP assay followed by qRT-PCR | NA | 28947139 |
| SATB2 | 21637 | NANOG | 20857 | Protein-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | ChIP assay | NA | 27472393 |
| MIR202 | 32080 | NORAD | 44311 | miRNA-mRNA Interaction | FACs for CSC marker | Pancreatic Cancer | Carcinoma | PANC-1 | RIP assay | NA | 34551785 |
| SLC39A6 | 18607 | ABCG2 | 74 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of SLC39A6 followed by RT-PCR | Down | 24294832 |
| SLC39A6 | 18607 | ABCG2 | 74 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of SLC39A6 followed by qRT-PCR | Down | 24294832 |
| HOXA9 | 5109 | ALDH1A1 | 402 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of HOXA9 followed by qRT-PCR | Down | 28947139 |
| SMO | 11119 | ALDH1A1 | 402 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated kncokdown of SMO followed by RT-PCR | Down | 26918054 |
| SMO | 11119 | ALDH1A1 | 402 | Gene-Gene Interaction | SFA and FACs for CSC marker | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of SMO followed by qRT-PCR | Down | 26918054 |
| LINC02041 | 52881 | ALDH1A1 | 402 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of LINC02041 followed by RT-PCR | Down | 30802827 |
| KLF12 | 6346 | BMI1 | 1066 | Gene-Gene Interaction | SFA and FACs for CSC marker | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of KLF12 followed by qRT-PCR | Down | 30866999 |
| PIM3 | 19310 | BMI1 | 1066 | Gene-Gene Interaction | FACs | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of PIM3 followed by qRT-PCR | Down | 28775772 |
| PIM3 | 19310 | CD24 | 1645 | Gene-Gene Interaction | FACs | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of PIM3 followed by qRT-PCR | Down | 28775772 |
| SATB2 | 21637 | CD24 | 1645 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of SATB2 followed by qRT-PCR | Down | 27472393 |
| LINC02041 | 52881 | CD24 | 1645 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of LINC02041 followed by RT-PCR | Down | 30802827 |
| HOXA9 | 5109 | CD44 | 1681 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of HOXA9 followed by qRT-PCR | Down | 28947139 |
| MAPK8 | 6881 | CD44 | 1681 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of MAPK8 followed by qRT-PCR | Down | 26840266 |
| PIM3 | 19310 | CD44 | 1681 | Gene-Gene Interaction | FACs | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of PIM3 followed by qRT-PCR | Down | 28775772 |
| SATB2 | 21637 | CD44 | 1681 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of SATB2 followed by qRT-PCR | Down | 27472393 |
| LINC02041 | 52881 | CD44 | 1681 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of LINC02041 followed by RT-PCR | Down | 30802827 |
| SMO | 11119 | CDH2 | 1759 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated kncokdown of SMO followed by RT-PCR | Down | 26918054 |
| PIM3 | 19310 | CXCR4 | 2561 | Gene-Gene Interaction | FACs | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of PIM3 followed by qRT-PCR | Down | 28775772 |
| KLF12 | 6346 | LGR5 | 4504 | Gene-Gene Interaction | SFA and FACs for CSC marker | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of KLF12 followed by qRT-PCR | Down | 30866999 |
| MIR137 | 31523 | KLF12 | 6346 | miRNA-mRNA Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | Transfection with MIR137 mimics followed by Luciferase Reporter assay | Down | 30866999 |
| SATB2 | 21637 | MYC | 7553 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of SATB2 followed by qRT-PCR | Down | 27472393 |
| NR5A2 | 7984 | NOTCH2 | 7882 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of NR5A2 followed by qRT-PCR | Down | 27996162 |
| HSF1 | 5224 | POU5F1 | 9221 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of HSF1 followed by qRT-PCR | Down | 35158144 |
| KLF12 | 6346 | POU5F1 | 9221 | Gene-Gene Interaction | SFA and FACs for CSC marker | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of KLF12 followed by qRT-PCR | Down | 30866999 |
| MAPK8 | 6881 | POU5F1 | 9221 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of MAPK8 followed by qRT-PCR | Down | 26840266 |
| NR5A2 | 7984 | POU5F1 | 9221 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of NR5A2 followed by qRT-PCR | Down | 27996162 |
| SATB2 | 21637 | POU5F1 | 9221 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of SATB2 followed by qRT-PCR | Down | 27472393 |
| HOXA9 | 5109 | PROM1 | 9454 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of HOXA9 followed by qRT-PCR | Down | 28947139 |
| KLF12 | 6346 | PROM1 | 9454 | Gene-Gene Interaction | SFA and FACs for CSC marker | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of KLF12 followed by qRT-PCR | Down | 30866999 |
| SATB2 | 21637 | PROM1 | 9454 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of SATB2 followed by qRT-PCR | Down | 27472393 |
| LINC02041 | 52881 | PROM1 | 9454 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of LINC02041 followed by RT-PCR | Down | 30802827 |
| SMO | 11119 | SNAI1 | 11128 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated kncokdown of SMO followed by RT-PCR | Down | 26918054 |
| MIR30B | 31625 | SNAI1 | 11128 | miRNA-mRNA Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | Transfection with MIR30B mimics followed by Luciferase Reporter assay and qRT-PCR | Down | 29937934 |
| HOXA9 | 5109 | SOX2 | 11195 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of HOXA9 followed by qRT-PCR | Down | 28947139 |
| HSF1 | 5224 | SOX2 | 11195 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of HSF1 followed by qRT-PCR | Down | 35158144 |
| KLF12 | 6346 | SOX2 | 11195 | Gene-Gene Interaction | SFA and FACs for CSC marker | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of KLF12 followed by qRT-PCR | Down | 30866999 |
| MAPK8 | 6881 | SOX2 | 11195 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of MAPK8 followed by qRT-PCR | Down | 26840266 |
| MIR1181 | 35262 | SOX2 | 11195 | miRNA-mRNA Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | Transfection with MIR1181 mimics followed by Luciferase Reporter assay and RNA immunoprecipitation assay | Down | 25444909 |
| MIR1181 | 35262 | STAT3 | 11364 | miRNA-mRNA Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | Transfection with MIR1181 mimics followed by Luciferase Reporter assay and RNA immunoprecipitation assay | Down | 25444909 |
| PIM3 | 19310 | EPCAM | 11529 | Gene-Gene Interaction | FACs | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of PIM3 followed by qRT-PCR | Down | 28775772 |
| HOXA9 | 5109 | LIN28A | 15986 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of HOXA9 followed by qRT-PCR | Down | 28947139 |
| SLC39A6 | 18607 | LIN28A | 15986 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of SLC39A6 followed by RT-PCR | Down | 24294832 |
| SLC39A6 | 18607 | LIN28A | 15986 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of SLC39A6 followed by qRT-PCR | Down | 24294832 |
| MIR21 | 31586 | KLF3 | 16516 | miRNA-mRNA Interaction | SFA and FACs for CSC marker | Pancreatic Cancer | Carcinoma | PANC-1 | Transfection with MIR21 mimics followed by Dual Luciferase Reporter assay and qRT-PCR | Down | 33728488 |
| HOXA9 | 5109 | NANOG | 20857 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of HOXA9 followed by qRT-PCR | Down | 28947139 |
| HSF1 | 5224 | NANOG | 20857 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of HSF1 followed by qRT-PCR | Down | 35158144 |
| KLF12 | 6346 | NANOG | 20857 | Gene-Gene Interaction | SFA and FACs for CSC marker | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of KLF12 followed by qRT-PCR | Down | 30866999 |
| MAPK8 | 6881 | NANOG | 20857 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of MAPK8 followed by qRT-PCR | Down | 26840266 |
| NR5A2 | 7984 | NANOG | 20857 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of NR5A2 followed by qRT-PCR | Down | 27996162 |
| SMO | 11119 | NANOG | 20857 | Gene-Gene Interaction | NA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated kncokdown of SMO followed by RT-PCR | Down | 26918054 |
| SMO | 11119 | NANOG | 20857 | Gene-Gene Interaction | SFA and FACs for CSC marker | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of SMO followed by qRT-PCR | Down | 26918054 |
| SATB2 | 21637 | NANOG | 20857 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | ShRNA mediated knockdown of SATB2 followed by qRT-PCR | Down | 27472393 |
| HOXA9 | 5109 | POU5F2 | 26367 | Gene-Gene Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | SiRNA mediated knockdown of HOXA9 followed by qRT-PCR | Down | 28947139 |
| MIR135B | 31760 | JADE1 | 30027 | miRNA-mRNA Interaction | SFA | Pancreatic Cancer | Carcinoma | PANC-1 | Transfection with MIR135B mimics followed by Luciferase Reporter assay and qRT-PCR | Down | 32351328 |