Record No:1
| ACCESS NO | D113740 |
| GENE_NAME | MCL1 |
| DESCRIPTION | MCL1 apoptosis regulator, BCL2 family member |
| ALIASES | BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT. |
| NCBI_ENTREZ_NO | 4170 |
| UNIPROT_ACCESS_NO | Q07820 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Airway Epithelial Cell Brushings |
| TECHNIQUES | Microarray |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE113185 |
| COMMENTS | The IL-6TS High subset (characterized by frequent exacerbations, eosinophilic airway inflammation and increased numbers of T cells and macrophages infiltrating the airway submucosa) did show a robust increase in the expression of MCL-1 as compared to IL-6TS Low and healthy controls. |
| REFERENCE | 29902480 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Protein binding, protein transmembrane transporter activity, protein homodimerization activity, protein heterodimerization activity, BH3 domain binding. |
| GO_BIOLOGICAL_PROCESS | Cell fate determination, apoptotic process, multicellular organism development, intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of autophagy, cytokine-mediated signaling pathway, cellular homeostasis, cell differentiation, response to cytokine, regulation of apoptotic process, negative regulation of apoptotic process, protein transmembrane transport, extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of anoikis, regulation of response to DNA damage stimulus, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of intrinsic apoptotic signaling pathway. |
| BIOGRID_INTERACTION_ID | 110338 |
| SNP_ID | - |
| DRUG_ID | 4251 4252 |
| STRUCTURE_ID | 204885 204886 204887 204888 204889 204890 |
| MONOCLONAL_ANTIBODY | Anti-MCL1 antibody for Human, Mouse, Rat |