Query 'BRCT domain' matched 12 Records
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Record No : 1 |
| Instance ID | 10212 | | Regular Expression | x(S)xxF | | Motif Instance | TSPTF | | Bait Uniprot Accession | Q9BX63 | | Bait Uniprot Identifier | FANCJ_HUMAN | | Bait Gene Name | BRIP1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 989-993 | | Critical Residues | P2; P3; P5 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Pull down; Mutation analysis | | Interaction ID | 20212 | | Interacting Domain | BRCT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15133502, 14576433 | | Comments | Phosphorylated serine (pS) sequence (989-993) in human BRCA1-Associated Carboxyl-terminal Helicase (BACH1) that mediates specific interaction with the carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein, which is cell cycle regulated and is required for DNA damage–induced checkpoint control during the transition from G2 to M phase of the cell cycle |
Record No : 2 |
| Instance ID | 10213 | | Regular Expression | x(S)xxF | | Motif Instance | CSPQF | | Bait Uniprot Accession | Q8WXE1 | | Bait Uniprot Identifier | ATRIP_HUMAN | | Bait Gene Name | ATRIP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 238-242 | | Critical Residues | P2; P3; P4; P5 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; X-ray crystallography; Co-IP; Pull down | | Interaction ID | 20213 | | Interacting Domain | BRCT domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17616665, 24073851 | | Comments | Phosphorylated serine (pS) sequence in human ATR-interacting protein (ATRIP) that mediates a direct physical interaction with the carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein and checkpoint function |
Record No : 3 |
| Instance ID | 10214 | | Regular Expression | x(S)xxF | | Motif Instance | RSPTF | | Bait Uniprot Accession | Q6UWZ7 | | Bait Uniprot Identifier | F175A_HUMAN | | Bait Gene Name | FAM175A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 405-409 | | Critical Residues | P2 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down | | Interaction ID | 20214 | | Interacting Domain | BRCT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17525340 | | Comments | Phosphorylated serine (pS) sequence in human BRCA1-A complex subunit Abraxas (FAM175A) that directly binds the BRCA1 BRCT repeats |
Record No : 4 |
| Instance ID | 10215 | | Regular Expression | x(S)xxF | | Motif Instance | SSPVF | | Bait Uniprot Accession | Q99708 | | Bait Uniprot Identifier | COM1_HUMAN | | Bait Gene Name | RBBP8 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 326-330 | | Critical Residues | P2; P5 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; X-ray crystallography | | Interaction ID | 20215 | | Interacting Domain | BRCT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16101277 | | Comments | Phosphorylated serine (pS) sequence in human DNA endonuclease RBBP8 or CtIP that mediates specific interaction with the carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein, and the side chain of Arg1775 in the cancer-associated BRCA1 mutation M1775R sterically clashes with the phenyl ring of CtIP Phe330, disrupting the BRCA1-CtIP interaction |
Record No : 5 |
| Instance ID | 10216 | | Regular Expression | x(S)xxF | | Motif Instance | QSPTF | | Bait Uniprot Accession | Q13085 | | Bait Uniprot Identifier | ACACA_HUMAN | | Bait Gene Name | ACACA | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1262-1266 | | Critical Residues | P2; P5 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Co-IP; Pull down | | Interaction ID | 20216 | | Interacting Domain | BRCT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18452305, 16698035 | | Comments | Phosphorylated serine (pS) sequence in human Acetyl-CoA carboxylase 1 (ACACA) that mediates specific interaction with the carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein |
Record No : 6 |
| Instance ID | 10217 | | Regular Expression | x(S)xxFxK | | Motif Instance | TSPTFNK | | Bait Uniprot Accession | Q9BX63 | | Bait Uniprot Identifier | FANCJ_HUMAN | | Bait Gene Name | BRIP1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 989-995 | | Critical Residues | P2 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutation analysis; Pull down; SPR; ITC | | Interaction ID | 20217 | | Interacting Domain | BRCT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15125843, 14576433 | | Comments | Phosphorylated serine (pS) sequence (989-995) in human BRCA1-Associated Carboxyl-terminal Helicase (BACH1) that mediates specific interaction with the carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein, which is cell cycle regulated and is required for DNA damage–induced checkpoint control during the transition from G2 to M phase of the cell cycle |
Record No : 7 |
| Instance ID | 10218 | | Regular Expression | x(S)xxY$ | | Motif Instance | ASQEY | | Bait Uniprot Accession | P16104 | | Bait Uniprot Identifier | H2AX_HUMAN | | Bait Gene Name | H2AFX | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 139-143 | | Critical Residues | P2; P5 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; ITC; Pull down; Mutation analysis | | Interaction ID | 20218 | | Interacting Domain | BRCT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16377563 | | Comments | MDC1/NFBD1 directly binds to Histone H2AX (gammaH2AX) by specifically interacting with the phosphoepitope at the gammaH2AX carboxyl terminus through its BRCT repeat domain, this interaction playing a central role in the mammalian response to DNA damage |
Record No : 8 |
| Instance ID | 11340 | | Regular Expression | SxxF | | Motif Instance | SPTF | | Bait Uniprot Accession | Q9BX63 | | Bait Uniprot Identifier | FANCJ_HUMAN | | Bait Gene Name | BRIP1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 990-993 | | Critical Residues | P1; P4 | | Motif PTM(s) | Phosphorylation at Ser-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; NMR; Site-directed Mutagenesis; SPR; ITC | | Interaction ID | 21340 | | Interacting Domain | BRCT domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15133503, 15133502, 15242590, 14576433 | | Comments | Motif mediating phosphorylation-dependent BRCA1-BACH1 interaction essential for G2 accumulation checkpoint control of the cell cycle |
Record No : 9 |
| Instance ID | 11341 | | Regular Expression | SxxF | | Motif Instance | SPVF | | Bait Uniprot Accession | Q99708 | | Bait Uniprot Identifier | COM1_HUMAN | | Bait Gene Name | RBBP8 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 327-330 | | Critical Residues | P1; P4 | | Motif PTM(s) | Phosphorylation at Ser-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutational analysis; Sequence based prediction; ITC | | Interaction ID | 21341 | | Interacting Domain | BRCT domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16101277, 15485915, 14578343 | | Comments | Motif mediating phosphorylation-dependent BRCA1-CtIP interaction essential for G2/M transition checkpoint control of the cell cycle |
Record No : 10 |
| Instance ID | 11342 | | Regular Expression | SxxF | | Motif Instance | SPQF | | Bait Uniprot Accession | Q8WXE1 | | Bait Uniprot Identifier | ATRIP_HUMAN | | Bait Gene Name | ATRIP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 239-242 | | Critical Residues | P1; P4 | | Motif PTM(s) | Phosphorylation at Ser-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC | | Interaction ID | 21342 | | Interacting Domain | BRCT domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 14578343, 24073851, 17616665 | | Comments | Motif responsible for ATRIP-BRCA1 interaction monitoring DNA replication checkpoint |
Record No : 11 |
| Instance ID | 11343 | | Regular Expression | SxxF | | Motif Instance | SPVF | | Bait Uniprot Accession | Q6PJG6 | | Bait Uniprot Identifier | BRAT1_HUMAN | | Bait Gene Name | BRAT1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 269-272 | | Critical Residues | P1; P4 | | Motif PTM(s) | Phosphorylation at Ser-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC | | Interaction ID | 21343 | | Interacting Domain | BRCT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14578343, 24073851, 16452482 | | Comments | Motif required for BRCA1-BRAT1 interaction involved in DNA damage-induced ATM activation |
Record No : 12 |
| Instance ID | 12171 | | Regular Expression | x(S)xxF | | Motif Instance | RSPVF | | Bait Uniprot Accession | Q6PJG6 | | Bait Uniprot Identifier | BRAT1_HUMAN | | Bait Gene Name | BRAT1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 268-272 | | Critical Residues | P2; P3; P4; P5 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; X-ray crystallography | | Interaction ID | 22171 | | Interacting Domain | BRCT domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 24073851 | | Comments | Phosphorylated serine (pS) sequence in human BRCA1-associated ATM activator 1 (BRAT1/BAAT1) that mediates a direct physical interaction with the carboxyl-terminal domain (BRCT) of the human Breast Cancer Gene 1 (BRCA1) protein |
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