Query 'Calcineurin-like phosphoesterase domain' matched 26 Records
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Record No : 1 |
| Instance ID | 10692 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | LKKLRFD | | Bait Uniprot Accession | P06400 | | Bait Uniprot Identifier | RB_HUMAN | | Bait Gene Name | RB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 872-878 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Phosphatase assay; ITC; Mutation analysis; X-ray crystallography | | Interaction ID | 20692 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20694007 | | Comments | An enzyme docking site in the human Retinoblastoma-associated protein (RB1/Rb) C-terminal domain that is required for association of Rb with the catalytic subunit of protein phosphatase 1 (PP1c) and efficient PP1c activity toward Rb |
Record No : 2 |
| Instance ID | 10693 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | NSRVTFS | | Bait Uniprot Accession | Q12972 | | Bait Uniprot Identifier | PP1R8_HUMAN | | Bait Gene Name | PPP1R8 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 198-204 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Phosphatase assay | | Interaction ID | 20693 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12657641 | | Comments | The RVXF motif of human Nuclear inhibitor of protein phosphatase 1 (NIPP1) that mediates binding to the catalytic subunit of protein phosphatase 1 (PP1c) |
Record No : 3 |
| Instance ID | 10694 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | KTKVKFD | | Bait Uniprot Accession | Q90623 | | Bait Uniprot Identifier | MYPT1_CHICK | | Bait Gene Name | PPP1R12A | | Bait Organism | Gallus gallus (Chicken) | | Sequence Position | 33-39 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20694 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15164081 | | Comments | The RVXF motif of chicken Protein phosphatase 1 regulatory subunit 12A (PPP1R12A) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CB) |
Record No : 4 |
| Instance ID | 10695 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | AKKVRFY | | Bait Uniprot Accession | O88809 | | Bait Uniprot Identifier | DCX_MOUSE | | Bait Gene Name | Dcx | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 52-58 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20695 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16530423 | | Comments | The RVXF motif of mouse Neuronal migration protein doublecortin (Dcx)/ Lissencephalin-X (Lis-X) that mediates binding to mouse Protein phosphatase 1C (PP1-gamma) catalytic subunit or Ppp1cc |
Record No : 5 |
| Instance ID | 10696 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | DRKKIQFS | | Bait Uniprot Accession | Q9UD71 | | Bait Uniprot Identifier | PPR1B_HUMAN | | Bait Gene Name | PPP1R1B | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 5-12 | | Critical Residues | P2; P3; P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20696 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10075680, 9108011 | | Comments | The RVXF motif of human DARPP-32 (PPP1R1B) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) at a site removed from the active site and that this interaction is not directly involved in inhibition of enzyme activity |
Record No : 6 |
| Instance ID | 10697 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | KRKSVTWP | | Bait Uniprot Accession | Q96QC0 | | Bait Uniprot Identifier | PP1RA_HUMAN | | Bait Gene Name | PPP1R10 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 395-402 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20697 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12574161 | | Comments | The RVXF motif of human PNUTS, Phosphatase 1 NUclear Targeting Subunit (PPP1R10), that mediates high affinity binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) and inhibition of PP1 activity |
Record No : 7 |
| Instance ID | 10698 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | DQKVDFD | | Bait Uniprot Accession | P34758 | | Bait Uniprot Identifier | SCD5_YEAST | | Bait Gene Name | SCD5 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 238-244 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Western blot | | Interaction ID | 20698 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12356757 | | Comments | Scd5p, a protein important for endocytosis and actin organization in yeast, interacts with Glc7p, a yeast Ser/Thr-specific protein phosphatase-1 (PP1), through the potential PP1-binding site at amino acids 238-244 of SCD5 |
Record No : 8 |
| Instance ID | 10699 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | SKKVRFS | | Bait Uniprot Accession | P34758 | | Bait Uniprot Identifier | SCD5_YEAST | | Bait Gene Name | SCD5 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 271-277 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Western blot | | Interaction ID | 20699 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12356757 | | Comments | Scd5p, a protein important for endocytosis and actin organization in yeast, interacts with Glc7p, a yeast Ser/Thr-specific protein phosphatase-1 (PP1), through the potential PP1-binding site at amino acids 271-277 of SCD5 |
Record No : 9 |
| Instance ID | 10700 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | PEKNVRFA | | Bait Uniprot Accession | P28006 | | Bait Uniprot Identifier | GAC1_YEAST | | Bait Gene Name | GAC1 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 67-74 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP | | Interaction ID | 20700 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11459182 | | Comments | GAC1 and GLC7 encode regulatory and catalytic subunits, respectively, of a type 1 phosphatase (PP1) in Saccharomyces cerevisiae, which interact with each other via the PP1-binding site of GAC1 |
Record No : 10 |
| Instance ID | 10701 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | KNRHIHFN | | Bait Uniprot Accession | Q00816 | | Bait Uniprot Identifier | REG1_YEAST | | Bait Gene Name | REG1 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 462-469 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20701 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10454550 | | Comments | In Saccharomyces cerevisiae, the protein phosphatase type 1 (PP1)-binding protein Reg1 interacts with the yeast PP1 homologue Glc7 through its PP1-binding site |
Record No : 11 |
| Instance ID | 10702 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | SRKIHFS | | Bait Uniprot Accession | O35274 | | Bait Uniprot Identifier | NEB2_RAT | | Bait Gene Name | Ppp1r9b | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 446-452 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Far Western blotting; Co-IP | | Interaction ID | 20702 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20305656, 10585469 | | Comments | The RVXF motif (446-452) of rat Neurabin-2/Spinophilin/Protein phosphatase 1 regulatory subunit 9B (Ppp1r9b) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) |
Record No : 12 |
| Instance ID | 10703 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | KGRVRFM | | Bait Uniprot Accession | O35274 | | Bait Uniprot Identifier | NEB2_RAT | | Bait Gene Name | Ppp1r9b | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 573-579 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20703 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20305656 | | Comments | The RVXF motif (573-579) of rat Neurabin-2/Spinophilin/Protein phosphatase 1 regulatory subunit 9B (Ppp1r9b) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) |
Record No : 13 |
| Instance ID | 10704 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | TRRVSFA | | Bait Uniprot Accession | Q16821 | | Bait Uniprot Identifier | PPR3A_HUMAN | | Bait Gene Name | PPP1R3A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 61-67 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 20704 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9155014 | | Comments | The RVXF motif of human Protein phosphatase 1 regulatory subunit 3A (PPP1R3A) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) |
Record No : 14 |
| Instance ID | 10705 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | SPKVTFE | | Bait Uniprot Accession | P38398 | | Bait Uniprot Identifier | BRCA1_HUMAN | | Bait Gene Name | BRCA1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 896-902 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis; Western blot | | Interaction ID | 20705 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17603999 | | Comments | The catalytic subunit of human protein phosphatase 1 (PPP1CA) interacts with and dephosphorylates human Breast cancer type 1 susceptibility protein (BRCA1) through the RVXF motif of BRCA1 and may thus serve as a general regulator for BRCA1 phosphorylation |
Record No : 15 |
| Instance ID | 10706 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | NRKIKFS | | Bait Uniprot Accession | O35867 | | Bait Uniprot Identifier | NEB1_RAT | | Bait Gene Name | Ppp1r9a | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 455-461 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Chromatography technologies; Affinity chromatography technology; Far Western blotting; Y2H; Co-IP; Mutation analysis | | Interaction ID | 20706 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10504266, 10585469 | | Comments | The RVXF motif of rat Neurabin-1/Protein phosphatase 1 regulatory subunit 9A (Ppp1r9a) that mediates binding to rat PP1-alpha catalytic subunit (Ppp1ca) and inhibits PP1 activity |
Record No : 16 |
| Instance ID | 10707 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | PARVRFS | | Bait Uniprot Accession | P08353 | | Bait Uniprot Identifier | ICP34_HHV1F | | Bait Gene Name | RL1 | | Bait Organism | Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1) | | Sequence Position | 190-196 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Competition binding; Mutation analysis | | Interaction ID | 20707 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9694816 | | Comments | The PP1-binding motif in the carboxyl-terminal domain of gamma134.5 protein of herpes simplex virus 1 may bind to the catalytic subunit of protein phosphatase 1 (PPP1CA) |
Record No : 17 |
| Instance ID | 10708 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | SPKGVLFS | | Bait Uniprot Accession | Q92667 | | Bait Uniprot Identifier | AKAP1_HUMAN | | Bait Gene Name | AKAP1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 151-158 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Affinity chromatography technology; Far Western blotting; Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20708 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10995432 | | Comments | The RVXF motif of human A-kinase anchoring protein AKAP149 (AKAP1) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) whereby AKAP149 recruits PP1 at the nuclear envelope (NE) upon somatic nuclear reformation, a prerequisite for assembly of B-type lamins |
Record No : 18 |
| Instance ID | 10709 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | KKKVHFS | | Bait Uniprot Accession | P51955 | | Bait Uniprot Identifier | NEK2_HUMAN | | Bait Gene Name | NEK2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 381-387 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Co-IP; Y2H; Co-IP; Mutation analysis | | Interaction ID | 20709 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10880350 | | Comments | The RVXF motif in the C-terminal region of the cell cycle-regulated protein serine/threonine NIMA-related kinase 2 (NEK2) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) |
Record No : 19 |
| Instance ID | 10710 | | Regular Expression | xP[^P]I[^P][IV][^P] | | Motif Instance | IPQIVID | | Bait Uniprot Accession | Q6VV64 | | Bait Uniprot Identifier | KCNKI_MOUSE | | Bait Gene Name | Kcnk18 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 209-215 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20710 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16569637 | | Comments | Targeting of the mouse Calmodulin-dependent calcineurin A subunit alpha isoform (Ppp3ca) to the Calcineurin (PP2B) docking motif in mouse Two-pore-domain potassium channel TRESK (Kcnk18) is required for the calcium-dependent activation of TRESK |
Record No : 20 |
| Instance ID | 10711 | | Regular Expression | xP[^P]I[^P][IV][^P] | | Motif Instance | TPIISIQ | | Bait Uniprot Accession | P53968 | | Bait Uniprot Identifier | CRZ1_YEAST | | Bait Gene Name | CRZ1 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 330-336 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20711 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11877380 | | Comments | In Saccharomyces cerevisiae, calcineurin positively regulates transcription in response to stress by dephosphorylating the transcription factor Crz1p/Tcn1p involving the calcineurin docking motif in Crz1p |
Record No : 21 |
| Instance ID | 10712 | | Regular Expression | xP[^P]I[^P][IV][^P] | | Motif Instance | LPVIAVN | | Bait Uniprot Accession | Q99332 | | Bait Uniprot Identifier | HPH1_YEAST | | Bait Gene Name | FRT1 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 71-77 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20712 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15189990 | | Comments | In Saccharomyces cerevisiae, calcineurin directly dephosphorylates High pH protein 1 (Hph1p) and interacts with it through the calcineurin docking motif in Hph1p |
Record No : 22 |
| Instance ID | 10713 | | Regular Expression | xP[^P]I[^P][IV][^P] | | Motif Instance | VPNIYIQ | | Bait Uniprot Accession | P40485 | | Bait Uniprot Identifier | SLM1_YEAST | | Bait Gene Name | SLM1 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 672-678 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Phosphatase assay | | Interaction ID | 20713 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16738335 | | Comments | In Saccharomyces cerevisiae, Ca2+/calmodulin-dependent phosphatase calcineurin dephosphorylates TORC2 effector protein SLM1 and interacts with it through the calcineurin docking motif in SLM1 |
Record No : 23 |
| Instance ID | 10714 | | Regular Expression | xP[^P]I[^P][IV][^P] | | Motif Instance | SPRIEIT | | Bait Uniprot Accession | O95644 | | Bait Uniprot Identifier | NFAC1_HUMAN | | Bait Gene Name | NFATC1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 117-123 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR | | Interaction ID | 20714 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17502104 | | Comments | The calcineurin docking motif on the human transcription factor NFAT (NFATC1) that mediates the interaction between human Calmodulin-dependent calcineurin A subunit alpha isoform (PPP3CA) and NFAT |
Record No : 24 |
| Instance ID | 10715 | | Regular Expression | xP[^P]I[^P][IV][^P] | | Motif Instance | KPKIIIT | | Bait Uniprot Accession | Q65142 | | Bait Uniprot Identifier | Q65142_ASF | | Bait Gene Name | 5EL | | Bait Organism | African swine fever virus (ASFV) | | Sequence Position | 204-210 | | Critical Residues | P2; P4; P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20715 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9677199, 11000210 | | Comments | The calcineurin docking motif in African swine fever virus protein A238L (5EL) required for A238L binding to the pig cellular phosphatase calcineurin (PPP3CA) |
Record No : 25 |
| Instance ID | 10716 | | Regular Expression | xP[^P]I[^P][IV][^P] | | Motif Instance | VPRITIS | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 843-849 | | Critical Residues | P2; P4; P5; P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Competition binding; Pull down(GST tag) | | Interaction ID | 20716 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21689596 | | Comments | The calcineurin docking motif on the Isoform 3 of human Dynamin-1 (DNM1) that mediates its interaction with human Calmodulin-dependent calcineurin A subunit alpha isoform (PPP3CA) |
Record No : 26 |
| Instance ID | 11985 | | Regular Expression | PxLx[IL]T | | Motif Instance | PSLPIT | | Bait Uniprot Accession | P0C215 | | Bait Uniprot Identifier | P12I_HTL1A | | Bait Gene Name | Not Available | | Bait Organism | Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) | | Sequence Position | 70-75 | | Critical Residues | P1; P3; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21985 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12601010 | | Comments | The conserved calcineurin-binding motif in human T lymphotropic virus type 1 Accessory protein p12I that mediates its interaction with human Calmodulin-dependent calcineurin A subunit alpha isoform (PPP3CA) and modulates NFAT activation to promote early virus infection of T lymphocytes, providing a novel mechanism for retrovirus-mediated cell activation |
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