Query 'HEAT repeat domain' matched 5 Records
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Record No : 1 |
| Instance ID | 10688 | | Regular Expression | [DEN][DEN]x{2,3}[ILMVA][DEN][DEN]L | | Motif Instance | EESLADDL | | Bait Uniprot Accession | O60934 | | Bait Uniprot Identifier | NBN_HUMAN | | Bait Gene Name | NBN | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 736-743 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Pull down | | Interaction ID | 20688 | | Interacting Domain | HEAT repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17507690, 15964794, 15758953 | | Comments | The extreme C terminus of human Nibrin/NBS1(NBN) contains an evolutionarily conserved sequence motif that is critical for binding to and activation of Serine-protein kinase ATM in the cellular response to DNA damage induced by ionizing radiation (IR) |
Record No : 2 |
| Instance ID | 10689 | | Regular Expression | [DEN][DEN]x{2,3}[ILMVA][DEN][DEN]L | | Motif Instance | EEAALDDL | | Bait Uniprot Accession | Q8WXE1 | | Bait Uniprot Identifier | ATRIP_HUMAN | | Bait Gene Name | ATRIP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 769-776 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20689 | | Interacting Domain | HEAT repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15758953 | | Comments | Conserved carboxy-terminal motif in human ATR-interacting protein (ATRIP) that is required for its interaction with human Serine/threonine-protein kinase ATR |
Record No : 3 |
| Instance ID | 10690 | | Regular Expression | [DEN][DEN]x{2,3}[ILMVA][DEN][DEN]L | | Motif Instance | EESLAEDL | | Bait Uniprot Accession | Q6XV80 | | Bait Uniprot Identifier | Q6XV80_XENLA | | Bait Gene Name | nbn | | Bait Organism | Xenopus laevis (African clawed frog) | | Sequence Position | 744-751 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP | | Interaction ID | 20690 | | Interacting Domain | HEAT repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15964794 | | Comments | The C terminus of Xenopus Nibrin (nbn/Nbs1) recruits ATM to damaged DNA and is essential for ATM activation |
Record No : 4 |
| Instance ID | 10691 | | Regular Expression | [DEN][DEN]x{2,3}[ILMVA][DEN][DEN]L | | Motif Instance | EEGGDVDDL | | Bait Uniprot Accession | P13010 | | Bait Uniprot Identifier | XRCC5_HUMAN | | Bait Gene Name | XRCC5 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 720-728 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP | | Interaction ID | 20691 | | Interacting Domain | HEAT repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15758953 | | Comments | Conserved carboxy-terminal motif in human DNA repair protein XRCC5 (Ku80) that is required for its interaction with human DNA-dependent protein kinase catalytic subunit (PRKDC) |
Record No : 5 |
| Instance ID | 11984 | | Regular Expression | [DEN][DEN]x{2,3}[ILMVA][DEN][DEN]L | | Motif Instance | DEDDEFNDL | | Bait Uniprot Accession | O43070 | | Bait Uniprot Identifier | NBS1_SCHPO | | Bait Gene Name | nbs1 | | Bait Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | | Sequence Position | 601-609 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21984 | | Interacting Domain | HEAT repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15964794 | | Comments | Two pairs of HEAT repeats in fission yeast ATM (Tel1) interact with an acidic patch at the C terminus of Nbs1 |
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