Query 'MATH domain' matched 29 Records
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Record No : 1 |
| Instance ID | 11014 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | PEQE | | Bait Uniprot Accession | P28908 | | Bait Uniprot Identifier | TNR8_HUMAN | | Bait Gene Name | TNFRSF8 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 561-564 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP; Pull down(GST tag) | | Interaction ID | 21014 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8662842 | | Comments | Human Lymphocyte activation antigen CD30, a member of the tumor necrosis factor (TNF) receptor family of proteins, initiate intracellular signaling by recruiting the C-domain of human TNF receptor-associated factor 1 (TRAF1) through a consensus motif in its cytoplasmic tail |
Record No : 2 |
| Instance ID | 11015 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | PEQE | | Bait Uniprot Accession | P28908 | | Bait Uniprot Identifier | TNR8_HUMAN | | Bait Gene Name | TNFRSF8 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 561-564 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP; Pull down(GST tag) | | Interaction ID | 21015 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8662842 | | Comments | Human Lymphocyte activation antigen CD30, a member of the tumor necrosis factor (TNF) receptor family of proteins, initiate intracellular signaling by recruiting the C-domain of human TNF receptor-associated factor 2 (TRAF2) through a consensus motif in its cytoplasmic tail |
Record No : 3 |
| Instance ID | 11016 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | PEQE | | Bait Uniprot Accession | P28908 | | Bait Uniprot Identifier | TNR8_HUMAN | | Bait Gene Name | TNFRSF8 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 561-564 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP; Pull down(GST tag) | | Interaction ID | 21016 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8662842 | | Comments | Human Lymphocyte activation antigen CD30, a member of the tumor necrosis factor (TNF) receptor family of proteins, initiate intracellular signaling by recruiting the C-domain of human TNF receptor-associated factor 3 (TRAF3)/CRAF1 through a consensus motif in its cytoplasmic tail |
Record No : 4 |
| Instance ID | 11017 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | PVQE | | Bait Uniprot Accession | P25942 | | Bait Uniprot Identifier | TNR5_HUMAN | | Bait Gene Name | CD40 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 250-253 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography; Peptide Binding Assay | | Interaction ID | 21017 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10518213, 9718306 | | Comments | Human B-cell surface antigen CD40, a TNF receptor superfamily member, associates with the human TNF receptor-associated factor 2 (TRAF2) through a TRAF2 binding site in the CD40 cytoplasmic domain |
Record No : 5 |
| Instance ID | 11018 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | SVEE | | Bait Uniprot Accession | P28908 | | Bait Uniprot Identifier | TNR8_HUMAN | | Bait Gene Name | TNFRSF8 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 578-581 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 21018 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10518213, 8662842 | | Comments | Human Lymphocyte activation antigen CD30, a TNF receptor superfamily member, associates with the human TNF receptor-associated factor 2 (TRAF2) through a TRAF2 binding site in its cytoplasmic domain |
Record No : 6 |
| Instance ID | 11019 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | SKEE | | Bait Uniprot Accession | P20333 | | Bait Uniprot Identifier | TNR1B_HUMAN | | Bait Gene Name | TNFRSF1B | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 424-427 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21019 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10206649 | | Comments | The TRAF domain of human TNF receptor-associated factor 2 (TRAF2) binds to the TRAF2-binding consensus motif in human Tumor necrosis factor receptor 2 (TNFR2/TNFRSF1B) |
Record No : 7 |
| Instance ID | 11020 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | PHQE | | Bait Uniprot Accession | P36941 | | Bait Uniprot Identifier | TNR3_HUMAN | | Bait Gene Name | LTBR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 402-405 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21020 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14517219 | | Comments | "Structurally adaptive ""hot spots"" in the binding crevice on the surface of human TNF receptor-associated factor 3 (TRAF3) promote molecular interactions with human Lymphotoxin-beta receptor (LTBR)" |
Record No : 8 |
| Instance ID | 11021 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | PIQE | | Bait Uniprot Accession | P43489 | | Bait Uniprot Identifier | TNR4_HUMAN | | Bait Gene Name | TNFRSF4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 262-265 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21021 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10518213 | | Comments | The TRAF domain of human TNF receptor-associated factor 2 (TRAF2) binds to the TRAF2-binding consensus motif in human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4)/ OX40L receptor |
Record No : 9 |
| Instance ID | 11022 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | PVQE | | Bait Uniprot Accession | P18347 | | Bait Uniprot Identifier | TSTP_SHV21 | | Bait Gene Name | STP | | Bait Organism | Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) | | Sequence Position | 60-63 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Co-IP; Mutation analysis | | Interaction ID | 21022 | | Interacting Domain | MATH domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10196286 | | Comments | The Transforming STP oncoprotein of the herpesvirus saimiri (HVS) are found to be stably associated with human TNF receptor-associated factor 2 (TRAF2) through its TRAF2-binding consensus motif |
Record No : 10 |
| Instance ID | 11023 | | Regular Expression | PxQxxD | | Motif Instance | PQQATD | | Bait Uniprot Accession | P03230 | | Bait Uniprot Identifier | LMP1_EBVB9 | | Bait Gene Name | LMP1 | | Bait Organism | Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) | | Sequence Position | 204-209 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 21023 | | Interacting Domain | MATH domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10518213 | | Comments | TRAF2-binding consensus motif in the Epstein-Barr virus (EBV) oncoprotein Latent membrane protein 1 (LMP1) that binds to human TNF receptor-associated factor 2 (TRAF2) |
Record No : 11 |
| Instance ID | 11024 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | QGPEESDEF | | Bait Uniprot Accession | P51617 | | Bait Uniprot Identifier | IRAK1_HUMAN | | Bait Gene Name | IRAK1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 702-710 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21024 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12140561 | | Comments | The C-terminal TRAF domain of human TNF receptor-associated factor 6 (TRAF6) interacts with human Interleukin-1 receptor-associated kinase 1 (IRAK1) through the TRAF6 binding site (702-710) of IRAK1 |
Record No : 12 |
| Instance ID | 11025 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | NQPVESDES | | Bait Uniprot Accession | P51617 | | Bait Uniprot Identifier | IRAK1_HUMAN | | Bait Gene Name | IRAK1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 583-591 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21025 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12140561 | | Comments | The C-terminal TRAF domain of human TNF receptor-associated factor 6 (TRAF6) interacts with human Interleukin-1 receptor-associated kinase 1 (IRAK1) through the TRAF6 binding site (583-591) of IRAK1 |
Record No : 13 |
| Instance ID | 11026 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | PSPQENSYV | | Bait Uniprot Accession | P51617 | | Bait Uniprot Identifier | IRAK1_HUMAN | | Bait Gene Name | IRAK1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 540-548 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21026 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12140561 | | Comments | The C-terminal TRAF domain of human TNF receptor-associated factor 6 (TRAF6) interacts with human Interleukin-1 receptor-associated kinase 1 (IRAK1) through the TRAF6 binding site (540-548) of IRAK1 |
Record No : 14 |
| Instance ID | 11027 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | NTPGEDHEP | | Bait Uniprot Accession | O35305 | | Bait Uniprot Identifier | TNR11_MOUSE | | Bait Gene Name | Tnfrsf11a | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 445-453 | | Critical Residues | P3; P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21027 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12140561 | | Comments | The C-terminal TRAF domain of human TNF receptor-associated factor 6 (TRAF6) interacts with the TRAF6 binding site (445-453) of mouse Osteoclast differentiation factor receptor (ODFR)/Rank/TRANCE-R |
Record No : 15 |
| Instance ID | 11028 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | QEPQEINFP | | Bait Uniprot Accession | P25942 | | Bait Uniprot Identifier | TNR5_HUMAN | | Bait Gene Name | CD40 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 231-239 | | Critical Residues | P3; P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21028 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10318845 | | Comments | Human TNF receptor-associated factor 6 (TRAF6) interacts with the membrane-proximal TRAF6 binding site in human B-cell surface antigen CD40 |
Record No : 16 |
| Instance ID | 11029 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | KIPTEDEYT | | Bait Uniprot Accession | O35305 | | Bait Uniprot Identifier | TNR11_MOUSE | | Bait Gene Name | Tnfrsf11a | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 338-346 | | Critical Residues | P3; P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21029 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12140561 | | Comments | The C-terminal TRAF domain of human TNF receptor-associated factor 6 (TRAF6) interacts with the TRAF6 binding site (338-346) of mouse Osteoclast differentiation factor receptor (ODFR)/Rank/TRANCE-R |
Record No : 17 |
| Instance ID | 11030 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | QEPLEVGEN | | Bait Uniprot Accession | O35305 | | Bait Uniprot Identifier | TNR11_MOUSE | | Bait Gene Name | Tnfrsf11a | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 371-379 | | Critical Residues | P3; P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21030 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12140561 | | Comments | The C-terminal TRAF domain of human TNF receptor-associated factor 6 (TRAF6) interacts with the TRAF6 binding site (371-379) of mouse Osteoclast differentiation factor receptor (ODFR)/Rank/TRANCE-R |
Record No : 18 |
| Instance ID | 11031 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | NTPVEDDEM | | Bait Uniprot Accession | P10221 | | Bait Uniprot Identifier | UL37_HHV11 | | Bait Gene Name | UL37 | | Bait Organism | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) | | Sequence Position | 1097-1105 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP; Mutation analysis | | Interaction ID | 21031 | | Interacting Domain | MATH domain | | Disease Association(s) | Herpes simplex virus (HSV) infection | | Inhibitor(s) | Unknown | | Reference(s) | 18682563 | | Comments | Herpesvirus Capsid assembly protein UL37 contains a TRAF6 binding site that is required for interaction with human TNF receptor-associated factor 6 (TRAF6) and activation of NF-kappaB |
Record No : 19 |
| Instance ID | 11038 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | PSSSH | | Bait Uniprot Accession | Q00987 | | Bait Uniprot Identifier | MDM2_HUMAN | | Bait Gene Name | MDM2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 147-151 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Mutation analysis; Pull down; Classical fluorescence spectroscopy | | Interaction ID | 21038 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16474402 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (147-151) in human E3 ubiquitin-protein ligase MDM2 |
Record No : 20 |
| Instance ID | 11039 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | AGVSE | | Bait Uniprot Accession | Q00987 | | Bait Uniprot Identifier | MDM2_HUMAN | | Bait Gene Name | MDM2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 226-230 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; ITC | | Interaction ID | 21039 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16402859 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (226-230) in human E3 ubiquitin-protein ligase MDM2 |
Record No : 21 |
| Instance ID | 11040 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | PGGSR | | Bait Uniprot Accession | P04637 | | Bait Uniprot Identifier | P53_HUMAN | | Bait Gene Name | TP53 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 359-363 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Mutation analysis; Classical fluorescence spectroscopy; ITC | | Interaction ID | 21040 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16474402, 16402859 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (359-363) in human Cellular tumor antigen P53 |
Record No : 22 |
| Instance ID | 11041 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | AHSSH | | Bait Uniprot Accession | P04637 | | Bait Uniprot Identifier | P53_HUMAN | | Bait Gene Name | TP53 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 364-368 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Mutation analysis; Classical fluorescence spectroscopy | | Interaction ID | 21041 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16474402 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (364-368) in human Cellular tumor antigen P53 |
Record No : 23 |
| Instance ID | 11042 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | AQCST | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 8-12 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Classical fluorescence spectroscopy; Pull down; Mutation analysis | | Interaction ID | 21042 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20713061 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (8-12) in human P53-binding protein MDM4/MDMX |
Record No : 24 |
| Instance ID | 11043 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | AHSSE | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 398-402 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Classical fluorescence spectroscopy; Pull down; Mutation analysis; X-ray crystallography | | Interaction ID | 21043 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20713061 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (398-402) in human P53-binding protein MDM4/MDMX |
Record No : 25 |
| Instance ID | 11044 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | PSTSS | | Bait Uniprot Accession | Q00987 | | Bait Uniprot Identifier | MDM2_HUMAN | | Bait Gene Name | MDM2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 397-401 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Classical fluorescence spectroscopy; Mutation analysis; X-ray crystallography | | Interaction ID | 21044 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20713061 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (397-401) in human E3 ubiquitin-protein ligase MDM2 |
Record No : 26 |
| Instance ID | 11045 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | ASQSQ | | Bait Uniprot Accession | Q00987 | | Bait Uniprot Identifier | MDM2_HUMAN | | Bait Gene Name | MDM2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 385-389 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Classical fluorescence spectroscopy | | Interaction ID | 21045 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20713061 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (385-389) in human E3 ubiquitin-protein ligase MDM2 |
Record No : 27 |
| Instance ID | 11046 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | PCNSV | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 388-392 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Classical fluorescence spectroscopy | | Interaction ID | 21046 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20713061 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (388-392) in human P53-binding protein MDM4/MDMX |
Record No : 28 |
| Instance ID | 11047 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | AGASC | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 470-474 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Classical fluorescence spectroscopy | | Interaction ID | 21047 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20713061 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (470-474) in human P53-binding protein MDM4/MDMX |
Record No : 29 |
| Instance ID | 11048 | | Regular Expression | PxE[^P]xS[^P] | | Motif Instance | PGEGPST | | Bait Uniprot Accession | P03211 | | Bait Uniprot Identifier | EBNA1_EBVB9 | | Bait Gene Name | EBNA1 | | Bait Organism | Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) | | Sequence Position | 442-448 | | Critical Residues | P3; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis; Classical fluorescence spectroscopy; X-ray crystallography | | Interaction ID | 21048 | | Interacting Domain | MATH domain | | Disease Association(s) | Epstein-Barr Virus (EBV) infection | | Inhibitor(s) | Unknown | | Reference(s) | 15808506 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 (also known as HAUSP) binds to a P/AXXS motif in the Epstein-Barr nuclear antigen 1 (EBNA1) protein of Epstein-Barr virus (EBV) and may contribute to the survival of Epstein-Barr virus-infected cells |
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