Query 'SH2 domain' matched 50 Records
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Record No : 1 |
| Instance ID | 10847 | | Regular Expression | (Y)xNx | | Motif Instance | YVNI | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 895-898 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Beta turn | | Experimental Method(s) | Pull down; Protein kinase assay | | Interaction ID | 20847 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7504175 | | Comments | Tyrosine-phosphorylated (Y895) rat Insulin receptor substrate 1 (Irs1) binds specifically to the Src homology 2 (SH2) domain of rat Growth factor receptor-bound protein 2 |
Record No : 2 |
| Instance ID | 10848 | | Regular Expression | (Y)xNx | | Motif Instance | YENP | | Bait Uniprot Accession | P05067 | | Bait Uniprot Identifier | A4_HUMAN | | Bait Gene Name | APP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 757-760 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Beta turn | | Experimental Method(s) | SPR; Pull down; Western blot | | Interaction ID | 20848 | | Interacting Domain | SH2 domain | | Disease Association(s) | Alzheimer's disease | | Inhibitor(s) | Unknown | | Reference(s) | 19602287 | | Comments | Phosphorylation of Tyr-757 in the intracellular domain (AID) of Human amyloid beta precursor protein (APP) creates a docking site for the SH2-domain of the human Adapter protein GRB2 |
Record No : 3 |
| Instance ID | 10849 | | Regular Expression | (Y)xNx | | Motif Instance | YVNQ | | Bait Uniprot Accession | P04626 | | Bait Uniprot Identifier | ERBB2_HUMAN | | Bait Gene Name | ERBB2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1139-1142 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR | | Interaction ID | 20849 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12975581, 11500516 | | Comments | Phosphorylation of Tyr-1139 in the Human Receptor tyrosine-protein kinase erbB-2 (ERBB2) creates a docking site for the SH2-domain of the human adapter protein Growth factor receptor-bound protein 7 (GRB7) |
Record No : 4 |
| Instance ID | 10850 | | Regular Expression | (Y)xNx | | Motif Instance | YVNV | | Bait Uniprot Accession | P08581 | | Bait Uniprot Identifier | MET_HUMAN | | Bait Gene Name | MET | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1356-1359 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Beta turn | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20850 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11063574, 12475979 | | Comments | Phosphorylation of Tyr-1356 in Human Proto-oncogene c-Met creates a docking site for the SH2-domain of the human Adapter protein GRB2 |
Record No : 5 |
| Instance ID | 10851 | | Regular Expression | (Y)xNx | | Motif Instance | YVNV | | Bait Uniprot Accession | P29353 | | Bait Uniprot Identifier | SHC1_HUMAN | | Bait Gene Name | SHC1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 427-430 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR | | Interaction ID | 20851 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10356320, 9710204 | | Comments | Tyrosine-phosphorylated (Y427) Human SHC-transforming protein 1 (SHC1) binds specifically to the SH2-domain of the human Adapter protein GRB2 |
Record No : 6 |
| Instance ID | 10852 | | Regular Expression | (Y)xNx | | Motif Instance | YVNV | | Bait Uniprot Accession | O54957 | | Bait Uniprot Identifier | LAT_MOUSE | | Bait Gene Name | Lat | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 175-178 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20852 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10811803 | | Comments | Tyrosine-phosphorylated (Y175) mouse 36 kDa phospho-tyrosine adapter protein Lat binds to the SH2 domain of mouse Grb2 adaptor protein |
Record No : 7 |
| Instance ID | 10853 | | Regular Expression | (Y)xNx | | Motif Instance | YVNV | | Bait Uniprot Accession | O54957 | | Bait Uniprot Identifier | LAT_MOUSE | | Bait Gene Name | Lat | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 195-198 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20853 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10811803 | | Comments | Tyrosine-phosphorylated (Y195) mouse 36 kDa phospho-tyrosine adapter protein Lat binds to the SH2 domain of mouse Grb2 adaptor protein |
Record No : 8 |
| Instance ID | 10854 | | Regular Expression | (Y)xNx | | Motif Instance | YENL | | Bait Uniprot Accession | O54957 | | Bait Uniprot Identifier | LAT_MOUSE | | Bait Gene Name | Lat | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 235-238 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20854 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10811803 | | Comments | Tyrosine-phosphorylated (Y235) mouse 36 kDa phospho-tyrosine adapter protein Lat binds to the SH2 domain of mouse Grb2 adaptor protein |
Record No : 9 |
| Instance ID | 10855 | | Regular Expression | (Y)xNx | | Motif Instance | YSNA | | Bait Uniprot Accession | P09619 | | Bait Uniprot Identifier | PGFRB_HUMAN | | Bait Gene Name | PDGFRB | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 716-719 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20855 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8940081 | | Comments | The SH2 domain of Human Epidermal growth factor receptor GRB-7 can directly bind to the autophosphorylated PDGF beta-receptor (PDGFRB) on Tyr-716 |
Record No : 10 |
| Instance ID | 10856 | | Regular Expression | (Y)xNx | | Motif Instance | YGNV | | Bait Uniprot Accession | P15391 | | Bait Uniprot Identifier | CD19_HUMAN | | Bait Gene Name | CD19 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 348-351 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 20856 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10706702 | | Comments | The SH2-domain of the human Adapter protein GRB2 binds to the human B-lymphocyte antigen CD19 at phosphorylated Y348 |
Record No : 11 |
| Instance ID | 10857 | | Regular Expression | (Y)[IV]x[VILP] | | Motif Instance | YIDL | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 1172-1175 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down(GST tag) | | Interaction ID | 20857 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11572799 | | Comments | Tyrosine-phosphorylated (Y1172) rat Insulin receptor substrate 1 (Irs1) binds to the SH2 domain of the rat tyrosine phosphatase Shp2/Ptpn11 |
Record No : 12 |
| Instance ID | 10858 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YQPG | | Bait Uniprot Accession | P12931 | | Bait Uniprot Identifier | SRC_HUMAN | | Bait Gene Name | SRC | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 530-533 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20858 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10360179 | | Comments | The human Proto-oncogene tyrosine-protein kinase SRC is maintained in an assembled, inactive conformation by intramolecular interactions of the phosphorylated C-terminal tail (Tyr-527) with the SH2 domain locks the molecule in an inhibited conformation |
Record No : 13 |
| Instance ID | 10859 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YEEI | | Bait Uniprot Accession | P03079 | | Bait Uniprot Identifier | MT_POVHA | | Bait Gene Name | Not Available | | Bait Organism | Hamster polyomavirus (HaPyV) | | Sequence Position | 324-327 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20859 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8985339 | | Comments | Middle-T antigen of hamster polyomavirus (HamT) associates with the SH2 domain of Proto-oncogene c-Fyn through phosphorylated Tyr-324, which is essential for the oncogenicity of HamT |
Record No : 14 |
| Instance ID | 10860 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YEPP | | Bait Uniprot Accession | Q60787 | | Bait Uniprot Identifier | LCP2_MOUSE | | Bait Gene Name | Lcp2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 145-148 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Extended conformation | | Experimental Method(s) | NMR | | Interaction ID | 20860 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16436281 | | Comments | The Src homology 2 (SH2) domain of mouse interleukin-2 tyrosine kinase (Itk) binds to a phosphotyrosine-containing peptide (pY) from mouse Lymphocyte cytosolic protein 2 (Lcp2/Slp-76), a phospholigand binding partner of Itk in T cells |
Record No : 15 |
| Instance ID | 10861 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YDEV | | Bait Uniprot Accession | O60500 | | Bait Uniprot Identifier | NPHN_HUMAN | | Bait Gene Name | NPHS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1176-1179 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20861 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16525419 | | Comments | The cytoplasmic tail of human Renal glomerulus-specific cell adhesion receptor Nephrin selectively binds the mouse Nck adaptor protein, which in turn control the podocyte cytoskeleton |
Record No : 16 |
| Instance ID | 10862 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YAEI | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 397-400 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Protein kinase assay; Co-IP; Mutation analysis; Western blot | | Interaction ID | 20862 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 7739563 | | Comments | Proto-oncogene c-Src, through its SH2 domain, stably associates with the focal adhesion kinase p125FAK phosphorylated at Tyr-397 |
Record No : 17 |
| Instance ID | 10863 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YEDA | | Bait Uniprot Accession | Q60598 | | Bait Uniprot Identifier | SRC8_MOUSE | | Bait Gene Name | Cttn | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 421-424 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Colocalization; SPR; Mutation analysis | | Interaction ID | 20863 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17606906 | | Comments | The mouse cytoplasmic adaptor protein Nck1 interacts with Src-phosphorylated cortactin (Cttn) via Tyr 421 to enhance actin assembly |
Record No : 18 |
| Instance ID | 10864 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YVPP | | Bait Uniprot Accession | Q14118 | | Bait Uniprot Identifier | DAG1_HUMAN | | Bait Gene Name | DAG1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 892-895 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Peptide binding to perpetrator; Mutation analysis | | Interaction ID | 20864 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11724572 | | Comments | Tyrosine phosphorylation of beta-dystroglycan at Tyr-892 allows its interaction with the SH2 domain of Proto-oncogene c-Fyn |
Record No : 19 |
| Instance ID | 10865 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YQYI | | Bait Uniprot Accession | P97318 | | Bait Uniprot Identifier | DAB1_MOUSE | | Bait Gene Name | Dab1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 198-201 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20865 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11279201 | | Comments | Mouse Disabled-1 (Dab1), an intracellular adapter protein, associates with the mouse Neuronal proto-oncogene tyrosine-protein kinase Src on phosphorylation of Tyr-198 |
Record No : 20 |
| Instance ID | 10866 | | Regular Expression | (Y)xxQ | | Motif Instance | YLPQ | | Bait Uniprot Accession | P25049 | | Bait Uniprot Identifier | TIP_SHV24 | | Bait Gene Name | Not Available | | Bait Organism | Saimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri) | | Sequence Position | 72-75 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20866 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10747948 | | Comments | The Tip protein from Herpesvirus saimiri is phosphorylated at Tyr-72 creating a consensus binding site for the DNA binding human transcription factor STAT3 for induction of STAT-dependent transcription during normal T cell activation events |
Record No : 21 |
| Instance ID | 10867 | | Regular Expression | (Y)[VLTFIC]xx | | Motif Instance | YTHM | | Bait Uniprot Accession | P06213 | | Bait Uniprot Identifier | INSR_HUMAN | | Bait Gene Name | INSR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1361-1364 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20867 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7983060 | | Comments | The phosphorylated YHTM motif in the COOH terminus of the human Insulin receptor (INSR) has the ability to bind to the human PI3-kinase subunit p85-alpha, thereby activating the enzyme and mediating the effect of insulin to activate PI 3-kinase |
Record No : 22 |
| Instance ID | 10868 | | Regular Expression | (Y)[VLTFIC]xx | | Motif Instance | YVKM | | Bait Uniprot Accession | P09793 | | Bait Uniprot Identifier | CTLA4_MOUSE | | Bait Gene Name | Ctla4 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 201-204 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Peptide binding to perpetrator | | Interaction ID | 20868 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8638161 | | Comments | The phosphotyrosine (Y201) sequence within the cytoplasmic tail of mouse Cytotoxic T-lymphocyte-associated antigen 4 (Ctla4) mediates binding to the SH2 domain of mouse Protein-tyrosine phosphatase SYP (Ptpn11) suggesting that the RAS pathway and T cell activation through the T cell receptor are regulated by Ctla4-associated SYP |
Record No : 23 |
| Instance ID | 10869 | | Regular Expression | (Y)[VLTFIC]xx | | Motif Instance | YTPM | | Bait Uniprot Accession | Q15303 | | Bait Uniprot Identifier | ERBB4_HUMAN | | Bait Gene Name | ERBB4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1056-1059 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Protein array; Co-IP; Competition binding | | Interaction ID | 20869 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18721752, 8617750, 10353604 | | Comments | Tyrosine-phosphorylated (Y1056) Human Proto-oncogene-like protein c-ErbB-4 binds to the N- and C-terminal SH2 domains of Human PI3K regulatory subunit alpha (PIK3R1) |
Record No : 24 |
| Instance ID | 10870 | | Regular Expression | (Y)[VLTFIC]xx | | Motif Instance | YLVV | | Bait Uniprot Accession | O43561 | | Bait Uniprot Identifier | LAT_HUMAN | | Bait Gene Name | LAT | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 132-135 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Far Western blotting; Pull down; Mutation analysis | | Interaction ID | 20870 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10811803, 11368773 | | Comments | Upon tyrosine phosphorylation (Y132), the integral membrane adaptor protein, human Linker for activation of T-cells (LAT), binds directly to the SH2-domain of the human Phospholipase C-gamma-1 (PLCG1) causing PLC-gamma activation which, in turn, regulates Ras activation |
Record No : 25 |
| Instance ID | 10871 | | Regular Expression | (Y)[VLTFIC]xx | | Motif Instance | YVPM | | Bait Uniprot Accession | Q13480 | | Bait Uniprot Identifier | GAB1_HUMAN | | Bait Gene Name | GAB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 447-450 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Edman degradation; Pull down(GST tag); Mass spectrometry; Mutation analysis | | Interaction ID | 20871 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10978177 | | Comments | Tyrosine-phosphorylated (Y447) Human GRB2-associated binder 1 (GAB1) binds to the SH2-domain of the the regulatory subunit (p85-alpha) of human phosphatidylinositol (PI)-3 kinase (PIK3R1) |
Record No : 26 |
| Instance ID | 10872 | | Regular Expression | (Y)[VLTFIC]xx | | Motif Instance | YVPM | | Bait Uniprot Accession | Q13480 | | Bait Uniprot Identifier | GAB1_HUMAN | | Bait Gene Name | GAB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 472-475 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Edman degradation; Pull down(GST tag); Mass spectrometry; Mutation analysis | | Interaction ID | 20872 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10978177 | | Comments | Tyrosine-phosphorylated (Y472) Human GRB2-associated binder 1 (GAB1) binds to the SH2-domain of the the regulatory subunit (p85-alpha) of human phosphatidylinositol (PI)-3 kinase (PIK3R1) |
Record No : 27 |
| Instance ID | 10873 | | Regular Expression | (Y)[VLTFIC]xx | | Motif Instance | YVPM | | Bait Uniprot Accession | Q13480 | | Bait Uniprot Identifier | GAB1_HUMAN | | Bait Gene Name | GAB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 619-622 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Edman degradation; Pull down(GST tag); Mass spectrometry; Mutation analysis | | Interaction ID | 20873 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10978177 | | Comments | Tyrosine-phosphorylated (Y619) Human GRB2-associated binder 1 (GAB1) binds to the SH2-domain of the the regulatory subunit (p85-alpha) of human phosphatidylinositol (PI)-3 kinase (PIK3R1) |
Record No : 28 |
| Instance ID | 10874 | | Regular Expression | G(Y)[KQ]xF | | Motif Instance | GYKAF | | Bait Uniprot Accession | P24394 | | Bait Uniprot Identifier | IL4RA_HUMAN | | Bait Gene Name | IL4R | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 602-606 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; EMSA | | Interaction ID | 20874 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9712048 | | Comments | Human Interleukin-4 receptor subunit alpha (IL4R) gene regulation domain contains a tyrosine-based sequence that are essential for the proper activation of Human STAT6 and can function as a mobile STAT6 activation cassette |
Record No : 29 |
| Instance ID | 11882 | | Regular Expression | YxxM | | Motif Instance | YICM | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 460-463 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21882 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif 1 (460-463) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 30 |
| Instance ID | 11883 | | Regular Expression | YxxM | | Motif Instance | YTEM | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 546-549 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21883 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif 2 (546-549) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 31 |
| Instance ID | 11884 | | Regular Expression | YxxM | | Motif Instance | YMPM | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 608-611 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21884 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif 3 (608-611) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 32 |
| Instance ID | 11885 | | Regular Expression | YxxM | | Motif Instance | YMPM | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 628-631 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21885 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif 4 (628-631) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 33 |
| Instance ID | 11886 | | Regular Expression | YxxM | | Motif Instance | YMMM | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 658-661 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21886 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif 5 (658-661) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 34 |
| Instance ID | 11887 | | Regular Expression | YxxM | | Motif Instance | YMNM | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 727-730 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21887 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif 6 (727-730) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 35 |
| Instance ID | 11888 | | Regular Expression | YxxM | | Motif Instance | YMNM | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Bait Organism | Rattus norvegicus (Rat) | | Sequence Position | 939-942 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21888 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif 7 (939-942) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 36 |
| Instance ID | 11889 | | Regular Expression | YxxM | | Motif Instance | YMDM | | Bait Uniprot Accession | P05622 | | Bait Uniprot Identifier | PGFRB_MOUSE | | Bait Gene Name | Pdgfrb | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 739-742 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21889 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif (739-742) in mouse Platelet-derived growth factor receptor beta that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 37 |
| Instance ID | 11890 | | Regular Expression | YxxM | | Motif Instance | YVPM | | Bait Uniprot Accession | P05622 | | Bait Uniprot Identifier | PGFRB_MOUSE | | Bait Gene Name | Pdgfrb | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 750-753 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21890 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif (750-753) in mouse Platelet-derived growth factor receptor beta that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 38 |
| Instance ID | 11891 | | Regular Expression | YxxM | | Motif Instance | YMPM | | Bait Uniprot Accession | P03077 | | Bait Uniprot Identifier | MT_POVMA | | Bait Gene Name | Not Available | | Bait Organism | Murine polyomavirus (strain A2) (MPyV) | | Sequence Position | 315-318 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21891 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif (315-318) in Middle T antigen of Murine polyomavirus that may mediate binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 39 |
| Instance ID | 11892 | | Regular Expression | YxxM | | Motif Instance | YVKM | | Bait Uniprot Accession | P16410 | | Bait Uniprot Identifier | CTLA4_HUMAN | | Bait Gene Name | CTLA4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 201-204 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutational analysis; SPR | | Interaction ID | 21892 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11583591 | | Comments | The medium chain mu 2 subunit (AP50) of the clathrin-associated adapter protein complex 2 (AP-2) interacts specifically with Cytotoxic T-lymphocyte-associated antigen 4 through the consensus sequence YXXPhi (where X can be any residue and Phi is a large hydrophobic residue) |
Record No : 40 |
| Instance ID | 11942 | | Regular Expression | Y[VI]N | | Motif Instance | YVN | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 896-898 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21942 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8491186 | | Comments | The short sequence motif present in Insulin receptor substrate 1 that specifically binds the SH2 domain of Growth factor receptor-bound protein 2 with high affinity |
Record No : 41 |
| Instance ID | 11943 | | Regular Expression | Y[VI]N | | Motif Instance | YVN | | Bait Uniprot Accession | P29353 | | Bait Uniprot Identifier | SHC1_HUMAN | | Bait Gene Name | SHC1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 427-429 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21943 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8491186 | | Comments | The short sequence motif present in SHC-transforming protein 1 that specifically binds the SH2 domain of Growth factor receptor-bound protein 2 with high affinity |
Record No : 42 |
| Instance ID | 11944 | | Regular Expression | Y[VI]N | | Motif Instance | YIN | | Bait Uniprot Accession | P00533 | | Bait Uniprot Identifier | EGFR_HUMAN | | Bait Gene Name | EGFR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1092-1094 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Competition binding assay; SPR; Dephosphorylation protection assay | | Interaction ID | 21944 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8491186, 7518560 | | Comments | The short sequence motif present in Epidermal growth factor receptor that specifically binds the SH2 domain of Growth factor receptor-bound protein 2 with high affinity |
Record No : 43 |
| Instance ID | 11945 | | Regular Expression | YxN | | Motif Instance | YSN | | Bait Uniprot Accession | P11137 | | Bait Uniprot Identifier | MTAP2_HUMAN | | Bait Gene Name | MAP2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 67-69 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Ligand Overlay Assay; ELISA | | Interaction ID | 21945 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15536091 | | Comments | The phosphorylated YxN motif present in human Microtubule-associated protein 2 that specifically binds the SH2 domain of Growth factor receptor-bound protein 2 |
Record No : 44 |
| Instance ID | 11988 | | Regular Expression | (Y)xNx | | Motif Instance | YDNY | | Bait Uniprot Accession | P09619 | | Bait Uniprot Identifier | PGFRB_HUMAN | | Bait Gene Name | PDGFRB | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 775-778 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 21988 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8940081 | | Comments | The SH2 domain of Human Epidermal growth factor receptor GRB-7 can directly bind to the autophosphorylated PDGF beta-receptor (PDGFRB) through Tyr-775 |
Record No : 45 |
| Instance ID | 12055 | | Regular Expression | [ILFV][ILFV]xxx[DE][DE]xx[DE] | | Motif Instance | LLSTSEEQIE | | Bait Uniprot Accession | P17181 | | Bait Uniprot Identifier | INAR1_HUMAN | | Bait Gene Name | IFNAR1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 491-500 | | Critical Residues | P1; P2; P7; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Coil | | Experimental Method(s) | X-ray crystallography; Site-directed mutagenesis; Pull down(GST tag) | | Interaction ID | 22055 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24704786 | | Comments | The peptide motif within the intracellular domain of human Interferon alpha receptor chain 1 (IFNAR1) that is necessary for its interaction with human Tyrosine kinase 2 (TYK2) as well as for TYK2 signaling |
Record No : 46 |
| Instance ID | 12137 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YVYI | | Bait Uniprot Accession | P10721 | | Bait Uniprot Identifier | KIT_HUMAN | | Bait Gene Name | KIT | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 568-571 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide Pull-Down | | Interaction ID | 22137 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23416972 | | Comments | Tyrosine-phosphorylated (Y568) human Mast/stem cell growth factor receptor KIT binds to the SH2 domain of the human Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)/ Protein-tyrosine phosphatase SHP-1 |
Record No : 47 |
| Instance ID | 12138 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YVYI | | Bait Uniprot Accession | P10721 | | Bait Uniprot Identifier | KIT_HUMAN | | Bait Gene Name | KIT | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 568-571 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide Pull-Down | | Interaction ID | 22138 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23416972 | | Comments | Tyrosine-phosphorylated (Y568) human Mast/stem cell growth factor receptor KIT binds to the SH2 domain of the human Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)/ Protein-tyrosine phosphatase SHP-2 |
Record No : 48 |
| Instance ID | 12139 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YVYI | | Bait Uniprot Accession | P10721 | | Bait Uniprot Identifier | KIT_HUMAN | | Bait Gene Name | KIT | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 568-571 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide Pull-Down | | Interaction ID | 22139 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23416972 | | Comments | Tyrosine-phosphorylated (Y568) human Mast/stem cell growth factor receptor KIT binds to the SH2 domain of the human Tyrosine-protein kinase SYK |
Record No : 49 |
| Instance ID | 12140 | | Regular Expression | (Y)[IV]x[VILP] | | Motif Instance | YIDP | | Bait Uniprot Accession | P10721 | | Bait Uniprot Identifier | KIT_HUMAN | | Bait Gene Name | KIT | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 570-573 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide Pull-Down | | Interaction ID | 22140 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23416972 | | Comments | Tyrosine-phosphorylated (Y570) human Mast/stem cell growth factor receptor KIT binds to the SH2 domain of the human Signal transducer and activator of transcription 1-alpha/beta (STAT1) |
Record No : 50 |
| Instance ID | 12141 | | Regular Expression | (Y)[IV]x[VILP] | | Motif Instance | YIDP | | Bait Uniprot Accession | P10721 | | Bait Uniprot Identifier | KIT_HUMAN | | Bait Gene Name | KIT | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 570-573 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide Pull-Down | | Interaction ID | 22141 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23416972 | | Comments | Tyrosine-phosphorylated (Y570) human Mast/stem cell growth factor receptor KIT binds to the SH2 domain of the human Crk-like protein (CRKL) |
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