Query 'TRAF-like domain' matched 9 Records
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Record No : 1 |
| Instance ID | 10916 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | APTAVVLPH | | Bait Uniprot Accession | Q16633 | | Bait Uniprot Identifier | OBF1_HUMAN | | Bait Gene Name | POU2AF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 46-54 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag); Mammalian two-hybrid assay; Classical fluorescence spectroscopy | | Interaction ID | 20916 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11483518 | | Comments | The PxAxVxP motif in human B-cell-specific coactivator OBF-1/BOB-1 (POU2AF1) that confer a high-affinity binding to human E3 ubiquitin-protein ligase SIAH1 |
Record No : 2 |
| Instance ID | 10917 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | APTAVVLPH | | Bait Uniprot Accession | Q16633 | | Bait Uniprot Identifier | OBF1_HUMAN | | Bait Gene Name | POU2AF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 46-54 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag); Mammalian two-hybrid assay; Classical fluorescence spectroscopy | | Interaction ID | 20917 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11483518 | | Comments | The PxAxVxP motif in human B-cell-specific coactivator OBF-1/BOB-1 (POU2AF1) that confer a high-affinity binding to human E3 ubiquitin-protein ligase SIAH2 |
Record No : 3 |
| Instance ID | 10918 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | IPTACVRPT | | Bait Uniprot Accession | P43146 | | Bait Uniprot Identifier | DCC_HUMAN | | Bait Gene Name | DCC | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1331-1339 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Classical fluorescence spectroscopy | | Interaction ID | 20918 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9334332 | | Comments | The PxAxVxP motif in human Netrin receptor DCC that confer binding to mouse E3 ubiquitin-protein ligase Siah2 |
Record No : 4 |
| Instance ID | 10919 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | KPTAYVRPM | | Bait Uniprot Accession | Q9UHB7 | | Bait Uniprot Identifier | AFF4_HUMAN | | Bait Gene Name | AFF4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 252-260 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 20919 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15459319 | | Comments | The PxAxVxP motif in human AFF4 that mediates binding to and degradation by human E3 ubiquitin-protein ligase SIAH1 |
Record No : 5 |
| Instance ID | 10920 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | KPAAVVAPI | | Bait Uniprot Accession | Q9HB71 | | Bait Uniprot Identifier | CYBP_HUMAN | | Bait Gene Name | CACYBP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 59-67 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Y2H; Co-IP | | Interaction ID | 20920 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16085652, 11389839 | | Comments | The PxAxVxP motif in human Calcyclin-binding protein (CACYBP)/Siah-interacting protein that mediates binding to and degradation by human E3 ubiquitin-protein ligase SIAH1 |
Record No : 6 |
| Instance ID | 10921 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | RPVAMVRPT | | Bait Uniprot Accession | Q27934 | | Bait Uniprot Identifier | PHYL_DROME | | Bait Gene Name | phyl | | Bait Organism | Drosophila melanogaster (Fruit fly) | | Sequence Position | 115-123 | | Critical Residues | P6; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutation analysis; Co-IP; Pull down | | Interaction ID | 20921 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16615911, 12626763 | | Comments | The PxAxVxP motif in Drosophila Phyllopod (phyl) protein that mediates binding to mouse E3 ubiquitin-protein ligase Siah1a |
Record No : 7 |
| Instance ID | 10922 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | IPCAAVSPN | | Bait Uniprot Accession | Q13118 | | Bait Uniprot Identifier | KLF10_HUMAN | | Bait Gene Name | KLF10 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 200-208 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20922 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12072443 | | Comments | Human Transforming growth factor beta (TGFbeta)-inducible early gene-1 (TIEG1)/ Krüppel-like transcription factor 10 (KLF10) and E3 ubiquitin ligase Seven in Absentia homologue-1 (SIAH1) interact through the PxAxVxP motif of TIEG1 |
Record No : 8 |
| Instance ID | 10923 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | PPRALVLPH | | Bait Uniprot Accession | Q86TG7 | | Bait Uniprot Identifier | PEG10_HUMAN | | Bait Gene Name | PEG10 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 253-261 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Co-IP | | Interaction ID | 20923 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12810624 | | Comments | Human Retrotransposon-derived protein PEG10 (paternally expressed gene 10) associates with human E3 ubiquitin-protein ligase SIAH1, a mediator of apoptosis, and overexpression of PEG10 decreases the cell death mediated by SIAH1 |
Record No : 9 |
| Instance ID | 10924 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | RPTAAVTPI | | Bait Uniprot Accession | Q7Z6J0 | | Bait Uniprot Identifier | SH3R1_HUMAN | | Bait Gene Name | SH3RF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 600-608 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Co-IP | | Interaction ID | 20924 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16230351 | | Comments | Human E3 ubiquitin-protein ligase SIAH1 is a binding partner for E3 ubiquitin-protein ligase SH3RF1/ POSH (Plenty of SH3s), a scaffold component of the apoptotic JNK pathway, and thus contributes to promotion of apoptotic death by activating the JNK pathway |
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