Query 'UHM domain' matched 3 Records
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Record No : 1 |
| Instance ID | 11035 | | Regular Expression | [KR]{1,4}[KR]x[KR]Wx | | Motif Instance | RKRRWS | | Bait Uniprot Accession | P54253 | | Bait Uniprot Identifier | ATX1_HUMAN | | Bait Gene Name | ATXN1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 770-775 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; ITC; Competition binding | | Interaction ID | 21035 | | Interacting Domain | UHM domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20037628 | | Comments | Human Ataxin-1 (ATXN1), a member of the polyglutamine (polyQ) expanded protein family, interacts with and influences the function of the splicing factor U2AF65 (U2AF2) via its UHM ligand motif (ULM) |
Record No : 2 |
| Instance ID | 11036 | | Regular Expression | [KR]{1,4}[KR]x[KR]Wx | | Motif Instance | KRKSRWD | | Bait Uniprot Accession | O75533 | | Bait Uniprot Identifier | SF3B1_HUMAN | | Bait Gene Name | SF3B1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 333-339 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; NMR; Pull down; Mutation analysis; ITC | | Interaction ID | 21036 | | Interacting Domain | UHM domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17589525, 16376933 | | Comments | Human Splicing factor 45 (SPF45)/ RNA-binding motif protein 17 (RBM17) binds to the UHM-ligand motif (ULM) present in human Splicing factor 3B subunit 1 (SF3B1) for regulating the alternative splicing of apoptosis regulatory gene FAS |
Record No : 3 |
| Instance ID | 11037 | | Regular Expression | [KR]{1,4}[KR]x[KR]Wx | | Motif Instance | KKRKRSRWN | | Bait Uniprot Accession | Q15637 | | Bait Uniprot Identifier | SF01_HUMAN | | Bait Gene Name | SF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 15-23 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; NMR | | Interaction ID | 21037 | | Interacting Domain | UHM domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12718882 | | Comments | The C-terminal RRM (RRM3) of human Splicing factor U2AF65/U2AF2 binds to the N-terminal UHM ligand motif (ULM) of human Splicing factor 1 (SF1) |
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