Query 'VHL beta domain' matched 5 Records
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Record No : 1 |
| Instance ID | 10580 | | Regular Expression | [IL]A(P)x{6,8}[FLIVM]x[FLIVM] | | Motif Instance | LAPYIPMDDDFQL | | Bait Uniprot Accession | Q16665 | | Bait Uniprot Identifier | HIF1A_HUMAN | | Bait Gene Name | HIF1A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 562-574 | | Critical Residues | P3 | | Motif PTM(s) | Hydroxylation at Pro-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC; SPR | | Interaction ID | 20580 | | Interacting Domain | VHL beta domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12050673, 12004076 | | Comments | In normoxia, human Hypoxia-inducible factor 1-alpha (HIF1A) is hydroxylated at Pro-564 to promote interaction with Von Hippel-Lindau disease tumor suppressor protein (VHL) which leads to ubiquitination and proteasomal degradation |
Record No : 2 |
| Instance ID | 10581 | | Regular Expression | [IL]A(P)x{6,8}[FLIVM]x[FLIVM] | | Motif Instance | LAPAAGDTIISLDF | | Bait Uniprot Accession | Q16665 | | Bait Uniprot Identifier | HIF1A_HUMAN | | Bait Gene Name | HIF1A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 400-413 | | Critical Residues | P3 | | Motif PTM(s) | Hydroxylation at Pro-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 20581 | | Interacting Domain | VHL beta domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12050673 | | Comments | In normoxia, human Hypoxia-inducible factor 1-alpha (HIF1A) is hydroxylated at Pro-402 to promote interaction with Von Hippel-Lindau disease tumor suppressor protein (VHL) which leads to ubiquitination and proteasomal degradation |
Record No : 3 |
| Instance ID | 10582 | | Regular Expression | [IL]A(P)x{6,8}[FLIVM]x[FLIVM] | | Motif Instance | LAPYISMDDDFQL | | Bait Uniprot Accession | Q9Y2N7 | | Bait Uniprot Identifier | HIF3A_HUMAN | | Bait Gene Name | HIF3A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 490-502 | | Critical Residues | P3 | | Motif PTM(s) | Hydroxylation at Pro-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Sequence based prediction | | Interaction ID | 20582 | | Interacting Domain | VHL beta domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12538644 | | Comments | Human Hypoxia-inducible factor 3-alpha (HIF3A) 1-3 splice variants is targeted for ubiquitylation by the pVHL complex by hydroxylation of Pro-492 to promote interaction with Von Hippel-Lindau disease tumor suppressor protein (VHL) |
Record No : 4 |
| Instance ID | 10583 | | Regular Expression | [IL]A(P)x{6,8}[FLIVM]x[FLIVM] | | Motif Instance | LAPTPGDAIISLDF | | Bait Uniprot Accession | Q99814 | | Bait Uniprot Identifier | EPAS1_HUMAN | | Bait Gene Name | EPAS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 403-416 | | Critical Residues | P3 | | Motif PTM(s) | Hydroxylation at Pro-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20583 | | Interacting Domain | VHL beta domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 14691554, 17986458 | | Comments | Human Hypoxia-inducible factor 2-alpha (HIF2A)/ Endothelial PAS domain-containing protein 1 (EPAS1) is targeted for ubiquitylation by the pVHL complex by hydroxylation of Pro-405 to promote interaction with Von Hippel-Lindau disease tumor suppressor protein (VHL) |
Record No : 5 |
| Instance ID | 10584 | | Regular Expression | [IL]A(P)x{6,8}[FLIVM]x[FLIVM] | | Motif Instance | LAPYIPMDGEDFQL | | Bait Uniprot Accession | Q99814 | | Bait Uniprot Identifier | EPAS1_HUMAN | | Bait Gene Name | EPAS1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 529-542 | | Critical Residues | P3 | | Motif PTM(s) | Hydroxylation at Pro-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20584 | | Interacting Domain | VHL beta domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 14691554, 17986458 | | Comments | Human Hypoxia-inducible factor 2-alpha (HIF2A)/ Endothelial PAS domain-containing protein 1 (EPAS1) is targeted for ubiquitylation by the pVHL complex by hydroxylation of Pro-531 to promote interaction with Von Hippel-Lindau disease tumor suppressor protein (VHL) |
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