Instance ID10168
Regular ExpressionxKENx
Motif InstanceNKEND
Bait Uniprot AccessionP30307
Bait Uniprot IdentifierMPIP3_HUMAN
Bait Gene NameCDC25C
Bait OrganismHomo sapiens (Human)
Sequence Position150-154
Critical ResiduesP2; P3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Competition binding
Interaction ID20168
Interacting DomainUnknown
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)11842186
CommentsKEN-box motif in human Cdc25C that mediates arsenite-induced ubiquitination of Cdc25C that may be involved in the arsenite-induced proteolytic down-regulation of Cdc25C activity causing cell cycle arrest at G(2)/M phase leading to suppression of cell proliferation and reduced cell viability

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)