|
| Instance ID | 10254 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | TSMTDFYHSKRRL | | Bait Uniprot Accession | P38936 | | Bait Uniprot Identifier | CDN1A_HUMAN | | Bait Gene Name | CDKN1A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 145-157 | | Critical Residues | P10; P11; P12 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Fluorescence technology; RNA interference; Ubiquitinase assay; Western blot; Co-IP; Alanine scanning; Co-IP | | Interaction ID | 20254 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18703516, 18794347 | | Comments | PCNA binding domain in CDK inhibitor p21 (CDKN1A) that is responsible for degradation of p21 by PCNA-coupled Cul4-DDB1(Cdt2)-dependent proteolysis |
|
