Instance ID10551
Regular ExpressionPPxLI
Motif InstancePPPLI
Bait Uniprot AccessionQ9Y618
Bait Uniprot IdentifierNCOR2_HUMAN
Bait Gene NameNCOR2
Bait OrganismHomo sapiens (Human)
Sequence Position1113-1117
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)NMR; ITC; Fluorescence polarization spectroscopy
Interaction ID20551
Interacting DomainMYND domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)23372760, 17560331
CommentsHuman DEAF-1 transcription regulation activity is mediated through its interaction with Nuclear receptor corepressor 2 (NCOR2/SMRT) via its MYND domain that binds to the PPxLI motif (1113-1117) of SMRT

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)