Instance ID10613
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQTTITSHFAK
Bait Uniprot AccessionP26358
Bait Uniprot IdentifierDNMT1_HUMAN
Bait Gene NameDNMT1
Bait OrganismHomo sapiens (Human)
Sequence Position164-173
Critical ResiduesP1; P3; P4; P7; P8
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutational analysis; Competition binding assay; Pull down(GST tag)
Interaction ID20613
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9302295
CommentsThe PCNA-binding motif in human DNA–(cytosine-5) methyltransferase (MCMT) that mediates its interaction with human Proliferating cell nuclear antigen (PCNA)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)