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| Instance ID | 10736 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GYENPTYK | | Bait Uniprot Accession | P05067 | | Bait Uniprot Identifier | A4_HUMAN | | Bait Gene Name | APP | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 756-763 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR; X-ray crystallography; ITC | | Interaction ID | 20736 | | Interacting Domain | PTB domain | | Disease Association(s) | Alzheimer's disease; Cerebral amyloid angiopathy | | Inhibitor(s) | Unknown | | Reference(s) | 10373567, 9321393, 18833287, 8887653 | | Comments | The interaction of the C-terminal phosphotyrosine-binding (PTB) domain of the human adaptor protein FE65/APBB1 with the NPxY PTB-binding motif of human amyloid precursor protein (APP), mediates APP trafficking and signalling, and is thought to regulate APP processing |
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