Instance ID10758
Regular Expression(x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y))
Motif InstanceIIENPQY
Bait Uniprot AccessionP04629
Bait Uniprot IdentifierNTRK1_HUMAN
Bait Gene NameNTRK1
Bait OrganismHomo sapiens (Human)
Sequence Position490-496
Critical ResiduesP7
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureBeta turn
Experimental Method(s)ITC; Mutation analysis; NMR
Interaction ID20758
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8524391
CommentsThe phosphotyrosine binding (PTB) domain of human SHC-transforming protein 1 (SHC1) binds to tyrosine-phosphorylated NPxY motif of human Neurotrophic tyrosine kinase receptor type 1 (NTRK1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)