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| Instance ID | 10870 | | Regular Expression | (Y)[VLTFIC]xx | | Motif Instance | YLVV | | Bait Uniprot Accession | O43561 | | Bait Uniprot Identifier | LAT_HUMAN | | Bait Gene Name | LAT | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 132-135 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Far Western blotting; Pull down; Mutation analysis | | Interaction ID | 20870 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10811803, 11368773 | | Comments | Upon tyrosine phosphorylation (Y132), the integral membrane adaptor protein, human Linker for activation of T-cells (LAT), binds directly to the SH2-domain of the human Phospholipase C-gamma-1 (PLCG1) causing PLC-gamma activation which, in turn, regulates Ras activation |
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