Instance ID11857
Regular Expression[ND]xY[ST]xxP
Motif InstanceQRYSSDP
Bait Uniprot AccessionP00533
Bait Uniprot IdentifierEGFR_HUMAN
Bait Gene NameEGFR
Bait OrganismHomo sapiens (Human)
Sequence Position1067-1073
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Tyr-P3
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Sequence based prediction
Interaction ID21857
Interacting DomainTKB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15737992, 10635327
CommentsConsensus sequence for phosphotyrosine recognition by the Cbl TKB domain in human Epidermal growth factor receptor, which indicates that Cbl adaptor proteins directly control downregulation of the receptor for the epidermal growth factor (EGFR) by recruiting ubiquitin-activating and -conjugating enzymes

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)