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Total : 87 Records
Record No : 1 |
| Instance ID | 10142 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | Q27974 | | Bait Uniprot Identifier | AUXI_BOVIN | | Bait Gene Name | DNAJC6 | | Sequence Position | 579-581 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis; Far Western blotting | | Interaction ID | 20142 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10380931 | | Comments | The DPF/W motif (579-581) of bovine auxilin that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 2 |
| Instance ID | 10143 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | Q27974 | | Bait Uniprot Identifier | AUXI_BOVIN | | Bait Gene Name | DNAJC6 | | Sequence Position | 605-607 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Far Western blotting; Mutation analysis | | Interaction ID | 20143 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10380931 | | Comments | The DPF/W motif (605-607) of bovine auxilin that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 3 |
| Instance ID | 10144 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | Q27974 | | Bait Uniprot Identifier | AUXI_BOVIN | | Bait Gene Name | DNAJC6 | | Sequence Position | 674-676 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Far Western blotting; Mutation analysis | | Interaction ID | 20144 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10380931 | | Comments | The DPF/W motif (674-676) of bovine auxilin that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 4 |
| Instance ID | 10155 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | P98082 | | Bait Uniprot Identifier | DAB2_HUMAN | | Bait Gene Name | DAB2 | | Sequence Position | 293-295 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down | | Interaction ID | 20155 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha1 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11247302 | | Comments | Characteristic DPF repeat (293-295) in human Disabled-2 (Dab2) that binds specifically to the C-terminal appendage domain of human Alpha-adaptin C |
Record No : 5 |
| Instance ID | 10156 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | P98082 | | Bait Uniprot Identifier | DAB2_HUMAN | | Bait Gene Name | DAB2 | | Sequence Position | 298-300 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down | | Interaction ID | 20156 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11247302 | | Comments | Characteristic DPF repeat (298-300) in human Disabled-2 (Dab2) that binds specifically to the C-terminal appendage domain of human Alpha-adaptin C |
Record No : 6 |
| Instance ID | 10211 | | Regular Expression | DAxGx | | Motif Instance | DAKGC | | Bait Uniprot Accession | O02002 | | Bait Uniprot Identifier | CASP1_DROME | | Bait Gene Name | Dcp-1 | | Sequence Position | 33-37 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20211 | | Interacting Domain | BIR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15580265 | | Comments | IAP-binding motif in Drosophila effector caspase DCP-1 that binds to the BIR1 domain of Drosophila IAP1 (dIAP1) |
Record No : 7 |
| Instance ID | 10230 | | Regular Expression | L[IVLMF]x[IVLMF][DE] | | Motif Instance | LLGLE | | Bait Uniprot Accession | Q27974 | | Bait Uniprot Identifier | AUXI_BOVIN | | Bait Gene Name | DNAJC6 | | Sequence Position | 496-500 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Peptide competition assay; Fluorescence polarization spectroscopy | | Interaction ID | 20230 | | Interacting Domain | Clathrin propeller repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14757058 | | Comments | Clathrin box motif in bovine auxilin (DNAJC6) that is sufficient for binding to the amino terminal beta propeller structure of Clathrin heavy chain |
Record No : 8 |
| Instance ID | 10304 | | Regular Expression | [^P]x[KR]xTQT | | Motif Instance | YTKETQT | | Bait Uniprot Accession | Q13409 | | Bait Uniprot Identifier | DC1I2_HUMAN | | Bait Gene Name | DYNC1I2 | | Sequence Position | 156-162 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20304 | | Interacting Domain | Dynein light chain type 1 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17551010 | | Comments | Dynein (Light Chain) binding KxTQT motif in human Cytoplasmic dynein 1 intermediate chain 2 that binds to DLC-8 (highly conserved 8-kDa light chain of Dynein) |
Record No : 9 |
| Instance ID | 10309 | | Regular Expression | [^P]x[KR]xTQT | | Motif Instance | YSKETQT | | Bait Uniprot Accession | O88485 | | Bait Uniprot Identifier | DC1I1_MOUSE | | Bait Gene Name | Dync1i1 | | Sequence Position | 149-155 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; NMR; Pull down; Competition binding; CD | | Interaction ID | 20309 | | Interacting Domain | Dynein light chain type 1 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11148209 | | Comments | The dynein light chain 8 binding motif of mouse Cytoplasmic dynein 1 intermediate chain 1 that binds to mouse DLC-8 |
Record No : 10 |
| Instance ID | 10420 | | Regular Expression | YxPPx[ILMV]R | | Motif Instance | YIPPHLR | | Bait Uniprot Accession | O00571 | | Bait Uniprot Identifier | DDX3X_HUMAN | | Bait Gene Name | DDX3X | | Sequence Position | 38-44 | | Critical Residues | P1; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20420 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17667941 | | Comments | Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by directly interacting with the dorsal surface of eIF4E through the conserved eIF4E-binding motif |
Record No : 11 |
| Instance ID | 10444 | | Regular Expression | PPxxF | | Motif Instance | PPVPF | | Bait Uniprot Accession | Q08877 | | Bait Uniprot Identifier | DYN3_RAT | | Bait Gene Name | Dnm3 | | Sequence Position | 809-813 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot | | Interaction ID | 20444 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9808459 | | Comments | Proline-rich motif in rat Dynamin-3 that is recognized by Class II EVH1 domain of Homer1 |
Record No : 12 |
| Instance ID | 10505 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | EEAAVIIQRTFRNHKKQSY | | Bait Uniprot Accession | Q54T86 | | Bait Uniprot Identifier | DWWA_DICDI | | Bait Gene Name | dwwA | | Sequence Position | 462-480 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Pull down | | Interaction ID | 20505 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14595117 | | Comments | Interaction of Dictyostelium discoideum Calmodulin (CaM) with the IQ motif of Dd WW domain containing protein A (DWWA), which is required for cytokinesis of Dictyostelium cells on solid surfaces |
Record No : 13 |
| Instance ID | 10523 | | Regular Expression | [KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF] | | Motif Instance | RRAKGAMGL | | Bait Uniprot Accession | P28562 | | Bait Uniprot Identifier | DUS1_HUMAN | | Bait Gene Name | DUSP1 | | Sequence Position | 54-62 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP | | Interaction ID | 20523 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11278799, 11953434 | | Comments | MAPK docking motif in human Mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1/CL100/DUSP1) that mediates binding to human MAP kinase 1 (or ERK-2) |
Record No : 14 |
| Instance ID | 10524 | | Regular Expression | [KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF] | | Motif Instance | RRLQKGNLPV | | Bait Uniprot Accession | Q16828 | | Bait Uniprot Identifier | DUS6_HUMAN | | Bait Gene Name | DUSP6 | | Sequence Position | 64-73 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Mass spectrometry study of hydrogen/deuterium exchange; X-ray crystallography | | Interaction ID | 20524 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10811804, 17046812, 16567630 | | Comments | MAPK docking motif in human Mitogen-activated protein kinase phosphatase 3 (MKP3/DUSP6) that mediates binding to human MAP kinase 1 (or ERK-2) |
Record No : 15 |
| Instance ID | 10525 | | Regular Expression | [KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF] | | Motif Instance | RRDAADFLL | | Bait Uniprot Accession | P53355 | | Bait Uniprot Identifier | DAPK1_HUMAN | | Bait Gene Name | DAPK1 | | Sequence Position | 1385-1393 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP; Pull down(GST tag) | | Interaction ID | 20525 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15616583 | | Comments | MAPK docking motif in human Death-associated protein kinase 1 (DAPK1) that mediates binding to human MAP kinase 1 (or ERK-2) |
Record No : 16 |
| Instance ID | 10531 | | Regular Expression | [KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF] | | Motif Instance | KRGRVPAPLNL | | Bait Uniprot Accession | Q03063 | | Bait Uniprot Identifier | DIG1_YEAST | | Bait Gene Name | DIG1 | | Sequence Position | 97-107 | | Critical Residues | P9; P11 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Peptide array | | Interaction ID | 20531 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14734536 | | Comments | Saccharomyces cerevisiae Down-regulator of invasive growth 1 (DIG1) contains a docking motif that selectively binds the yeast Mitogen-activated protein kinase KSS1 |
Record No : 17 |
| Instance ID | 10532 | | Regular Expression | [KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF] | | Motif Instance | KRKRVPPALNF | | Bait Uniprot Accession | Q03373 | | Bait Uniprot Identifier | DIG2_YEAST | | Bait Gene Name | DIG2 | | Sequence Position | 100-110 | | Critical Residues | P9; P11 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Peptide array | | Interaction ID | 20532 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14734536 | | Comments | Saccharomyces cerevisiae Down-regulator of invasive growth 2 (DIG2) contains a docking motif that selectively binds the yeast Mitogen-activated protein kinase KSS1 |
Record No : 18 |
| Instance ID | 10539 | | Regular Expression | FxFP | | Motif Instance | FNFP | | Bait Uniprot Accession | P28562 | | Bait Uniprot Identifier | DUS1_HUMAN | | Bait Gene Name | DUSP1 | | Sequence Position | 339-342 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20539 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9925641, 16286470 | | Comments | The FXFP motif in human Mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1/CL100/DUSP1) that mediates binding to human MAP kinase 1 (or ERK-2) |
Record No : 19 |
| Instance ID | 10613 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QTTITSHFAK | | Bait Uniprot Accession | P26358 | | Bait Uniprot Identifier | DNMT1_HUMAN | | Bait Gene Name | DNMT1 | | Sequence Position | 164-173 | | Critical Residues | P1; P3; P4; P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutational analysis; Competition binding assay; Pull down(GST tag) | | Interaction ID | 20613 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9302295 | | Comments | The PCNA-binding motif in human DNA–(cytosine-5) methyltransferase (MCMT) that mediates its interaction with human Proliferating cell nuclear antigen (PCNA) |
Record No : 20 |
| Instance ID | 10632 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | KLMTTV | | Bait Uniprot Accession | Q8QG92 | | Bait Uniprot Identifier | DCT1B_XENLA | | Bait Gene Name | dact1-b | | Sequence Position | 819-824 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Pull down(GST tag); Y2H; Mutation analysis | | Interaction ID | 20632 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11970895 | | Comments | C-terminal class 1 PDZ-binding motif in Xenopus Dapper (Dpr) that mediates its interaction with the Xenopus Dsh (XDsh)/ dishevelled homolog dvl2 |
Record No : 21 |
| Instance ID | 10633 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | GYSTRL | | Bait Uniprot Accession | Q13268 | | Bait Uniprot Identifier | DHRS2_HUMAN | | Bait Gene Name | DHRS2 | | Sequence Position | 253-258 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20633 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17384233 | | Comments | C-terminal class 1 PDZ-binding motif in human Dicarbonyl reductase HEP27 or DHRS2 that binds to the PDZ domain of human Na(+)/H(+) exchange regulatory cofactor NHERF2 (SLC9A3R2) |
Record No : 22 |
| Instance ID | 10634 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | EAQTRL | | Bait Uniprot Accession | P97836 | | Bait Uniprot Identifier | DLGP1_RAT | | Bait Gene Name | Dlgap1 | | Sequence Position | 987-992 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20634 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12954649 | | Comments | C-terminal class 1 PDZ-binding motif in rat Dlgap1/Gkap that binds to the rat Shank1 PDZ domain |
Record No : 23 |
| Instance ID | 10695 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | AKKVRFY | | Bait Uniprot Accession | O88809 | | Bait Uniprot Identifier | DCX_MOUSE | | Bait Gene Name | Dcx | | Sequence Position | 52-58 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20695 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16530423 | | Comments | The RVXF motif of mouse Neuronal migration protein doublecortin (Dcx)/ Lissencephalin-X (Lis-X) that mediates binding to mouse Protein phosphatase 1C (PP1-gamma) catalytic subunit or Ppp1cc |
Record No : 24 |
| Instance ID | 10716 | | Regular Expression | xP[^P]I[^P][IV][^P] | | Motif Instance | VPRITIS | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Sequence Position | 843-849 | | Critical Residues | P2; P4; P5; P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Competition binding; Pull down(GST tag) | | Interaction ID | 20716 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21689596 | | Comments | The calcineurin docking motif on the Isoform 3 of human Dynamin-1 (DNM1) that mediates its interaction with human Calmodulin-dependent calcineurin A subunit alpha isoform (PPP3CA) |
Record No : 25 |
| Instance ID | 10779 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LSCRE | | Bait Uniprot Accession | Q9WIJ4 | | Bait Uniprot Identifier | CLINK_FBNY1 | | Bait Gene Name | DNA-C | | Sequence Position | 110-114 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20779 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10708410 | | Comments | The Rb-binding LxCxE motif in the Cell cycle link protein (Clink/DNA-C) of Faba bean necrotic yellows virus that mediates binding to the human retinoblastoma protein (RB) |
Record No : 26 |
| Instance ID | 10780 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LSCRE | | Bait Uniprot Accession | Q9WIJ4 | | Bait Uniprot Identifier | CLINK_FBNY1 | | Bait Gene Name | DNA-C | | Sequence Position | 110-114 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20780 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10708410 | | Comments | The Rb-binding LxCxE motif in the Cell cycle link protein (Clink/DNA-C) of Faba bean necrotic yellows virus that mediates binding to the plant RB homologue ZmRBR1 from maize |
Record No : 27 |
| Instance ID | 10837 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGLPS | | Bait Uniprot Accession | Q12959 | | Bait Uniprot Identifier | DLG1_HUMAN | | Bait Gene Name | DLG1 | | Sequence Position | 597-602 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Western blot; Co-IP; RNA interference | | Interaction ID | 20837 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12902344 | | Comments | The DSGxxS phospho-dependent degron present in human Disks large homolog 1 (DLG1) that mediates phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor |
Record No : 28 |
| Instance ID | 10864 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YVPP | | Bait Uniprot Accession | Q14118 | | Bait Uniprot Identifier | DAG1_HUMAN | | Bait Gene Name | DAG1 | | Sequence Position | 892-895 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Peptide binding to perpetrator; Mutation analysis | | Interaction ID | 20864 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11724572 | | Comments | Tyrosine phosphorylation of beta-dystroglycan at Tyr-892 allows its interaction with the SH2 domain of Proto-oncogene c-Fyn |
Record No : 29 |
| Instance ID | 10865 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YQYI | | Bait Uniprot Accession | P97318 | | Bait Uniprot Identifier | DAB1_MOUSE | | Bait Gene Name | Dab1 | | Sequence Position | 198-201 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20865 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11279201 | | Comments | Mouse Disabled-1 (Dab1), an intracellular adapter protein, associates with the mouse Neuronal proto-oncogene tyrosine-protein kinase Src on phosphorylation of Tyr-198 |
Record No : 30 |
| Instance ID | 10889 | | Regular Expression | PxxPx[KR] | | Motif Instance | PSRPNR | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Sequence Position | 833-838 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20889 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9148966 | | Comments | The SH3 domain of Human neuronal protein Amphiphysin binds with high affinity to a single site (833-838) in the long proline-rich region of human Dynamin-1 |
Record No : 31 |
| Instance ID | 10894 | | Regular Expression | PxxPx[KR] | | Motif Instance | PQIPSR | | Bait Uniprot Accession | P50570 | | Bait Uniprot Identifier | DYN2_HUMAN | | Bait Gene Name | DNM2 | | Sequence Position | 829-834 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; Competition binding; SPR; Pull down | | Interaction ID | 20894 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15483625 | | Comments | The consensus class II SH3-binding motif in Human Dynamin-2 that interacts with the SH3 domain of Human Myc box-dependent-interacting protein 1 (BIN1) |
Record No : 32 |
| Instance ID | 10907 | | Regular Expression | xxx[PV]xxP | | Motif Instance | SPPPYVP | | Bait Uniprot Accession | Q14118 | | Bait Uniprot Identifier | DAG1_HUMAN | | Bait Gene Name | DAG1 | | Sequence Position | 888-894 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Solid phase assay; SPR | | Interaction ID | 20907 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Dystrophin | | Reference(s) | 10903901 | | Comments | High-affinity interaction between the SH3 domains of human Adapter protein GRB2 and a proline-rich region within human Beta-dystroglycan which is inhibited by dystrophin |
Record No : 33 |
| Instance ID | 10918 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | IPTACVRPT | | Bait Uniprot Accession | P43146 | | Bait Uniprot Identifier | DCC_HUMAN | | Bait Gene Name | DCC | | Sequence Position | 1331-1339 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Classical fluorescence spectroscopy | | Interaction ID | 20918 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9334332 | | Comments | The PxAxVxP motif in human Netrin receptor DCC that confer binding to mouse E3 ubiquitin-protein ligase Siah2 |
Record No : 34 |
| Instance ID | 10958 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | IVLSDSD | | Bait Uniprot Accession | Q9UER7 | | Bait Uniprot Identifier | DAXX_HUMAN | | Bait Gene Name | DAXX | | Sequence Position | 734-740 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Pull down; Mutation analysis; Western blot; NMR | | Interaction ID | 20958 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17081986, 21474068 | | Comments | The SUMO-interacting motif (SIM) of human Death domain-associated protein 6 (DAXX) that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 35 |
| Instance ID | 10993 | | Regular Expression | ([KR][^ED]{0,5}[ST]xIP[^ED]{5,5})|([^ED]{5,5}[ST]xIP[^ED]{0,5}[KR]) | | Motif Instance | STAKPSKIPTPQRK | | Bait Uniprot Accession | Q03001 | | Bait Uniprot Identifier | DYST_HUMAN | | Bait Gene Name | DST | | Sequence Position | 7545-7558 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Classical fluorescence spectroscopy; Pull down; ITC; Mutation analysis | | Interaction ID | 20993 | | Interacting Domain | EBH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19632184 | | Comments | The C-terminal EBH domain of human End-binding protein 1 (EB1) or MAPRE1 binds to the SxIP motif of human Dystonin (DST) |
Record No : 36 |
| Instance ID | 11009 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | ERGEAEGC | | Bait Uniprot Accession | Q9NRI5 | | Bait Uniprot Identifier | DISC1_HUMAN | | Bait Gene Name | DISC1 | | Sequence Position | 222-229 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence polarization spectroscopy; Mutation analysis; Co-IP | | Interaction ID | 21009 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22153077 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human Disrupted in schizophrenia 1 protein (DISC1) |
Record No : 37 |
| Instance ID | 11034 | | Regular Expression | [FY]xLxP | | Motif Instance | YLLTP | | Bait Uniprot Accession | Q9H816 | | Bait Uniprot Identifier | DCR1B_HUMAN | | Bait Gene Name | DCLRE1B | | Sequence Position | 504-508 | | Critical Residues | P1; P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC; Co-IP; Mutation analysis | | Interaction ID | 21034 | | Interacting Domain | TRFH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18202258 | | Comments | The telomeric repeat binding factor (TRF) homology (TRFH) domain of human Telomeric repeat-binding factor 2 (TERF2/TRF2) recognizes and directly interacts with the [Y/F]XL motif in human 5' exonuclease Apollo/ DNA cross-link repair 1B protein (DCLRE1B) and regulates telomere maintenance |
Record No : 38 |
| Instance ID | 11050 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | Q14118 | | Bait Uniprot Identifier | DAG1_HUMAN | | Bait Gene Name | DAG1 | | Sequence Position | 889-992 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21050 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10932245 | | Comments | The C-terminal region of human Dystrophin (DMD) binds the cytoplasmic tail of human Dystroglycan (DAG1) through the interaction of its WW domain with a proline-rich motif in the tail of DAG1 |
Record No : 39 |
| Instance ID | 11156 | | Regular Expression | xxx([ST])Px | | Motif Instance | ASQSPR | | Bait Uniprot Accession | Q9UER7 | | Bait Uniprot Identifier | DAXX_HUMAN | | Bait Gene Name | DAXX | | Sequence Position | 175-180 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Mutation analysis; Co-IP | | Interaction ID | 21156 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17938171 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-178-Pro motif in the human Death domain-associated protein 6 (DAXX) and plays an important role in the negative regulation of DAXX, thereby inhibiting the oxidative stress-induced cellular apoptotic response |
Record No : 40 |
| Instance ID | 11274 | | Regular Expression | xG[IV]QVD | | Motif Instance | IGIQVD | | Bait Uniprot Accession | O14490 | | Bait Uniprot Identifier | DLGP1_HUMAN | | Bait Gene Name | DLGAP1 | | Sequence Position | 652-657 | | Critical Residues | P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21274 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11513870 | | Comments | The LC8 dynein light chain binding motif (652-657) in human Disks large-associated protein 1 (DLGAP1) that binds to the rat 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 41 |
| Instance ID | 11275 | | Regular Expression | xG[IV]QVD | | Motif Instance | VGVQVE | | Bait Uniprot Accession | O14490 | | Bait Uniprot Identifier | DLGP1_HUMAN | | Bait Gene Name | DLGAP1 | | Sequence Position | 677-682 | | Critical Residues | P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21275 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11513870 | | Comments | The LC8 dynein light chain binding motif (677-682) in human Disks large-associated protein 1 (DLGAP1) that binds to the rat 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 42 |
| Instance ID | 11305 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | TKETQTP | | Bait Uniprot Accession | Q13409 | | Bait Uniprot Identifier | DC1I2_HUMAN | | Bait Gene Name | DYNC1I2 | | Sequence Position | 157-163 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; NMR; protection from proteolytic digestion; pull down(GST tag); EMSA; Fluorescence Spectroscopy | | Interaction ID | 21305 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17551010, 16949604, 15581372 | | Comments | The N-terminal domain of human Cytoplasmic dynein 1 intermediate chain 2 (DYNC1I2) is a highly disordered monomer but gains helical structure upon binding to Drosophila cytoplasmic dynein light-chain subunit LC8 (or ctp) |
Record No : 43 |
| Instance ID | 11308 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | SKETQTP | | Bait Uniprot Accession | O88485 | | Bait Uniprot Identifier | DC1I1_MOUSE | | Bait Gene Name | Dync1i1 | | Sequence Position | 150-156 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21308 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in mouse Cytoplasmic dynein 1 intermediate chain 1 (Dync1i1) that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 44 |
| Instance ID | 11309 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | SKETQTP | | Bait Uniprot Accession | O88485 | | Bait Uniprot Identifier | DC1I1_MOUSE | | Bait Gene Name | Dync1i1 | | Sequence Position | 150-156 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21309 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in mouse Cytoplasmic dynein 1 intermediate chain 1 (Dync1i1) that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 45 |
| Instance ID | 11310 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | DLGIQVD | | Bait Uniprot Accession | Q9Y6K1 | | Bait Uniprot Identifier | DNM3A_HUMAN | | Bait Gene Name | DNMT3A | | Sequence Position | 652-658 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21310 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in human DNA (cytosine-5)-methyltransferase 3A (DNMT3A) that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 46 |
| Instance ID | 11311 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | DLGIQVD | | Bait Uniprot Accession | Q9Y6K1 | | Bait Uniprot Identifier | DNM3A_HUMAN | | Bait Gene Name | DNMT3A | | Sequence Position | 652-658 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21311 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in human DNA (cytosine-5)-methyltransferase 3A (DNMT3A) that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 47 |
| Instance ID | 11352 | | Regular Expression | PxAxVxP | | Motif Instance | PTACVRP | | Bait Uniprot Accession | P43146 | | Bait Uniprot Identifier | DCC_HUMAN | | Bait Gene Name | DCC | | Sequence Position | 1332-1338 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21352 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9334332, 12626763 | | Comments | Peptide motif that mediates the interaction of the DCC cytoplasmic domain with SIAH1 |
Record No : 48 |
| Instance ID | 11353 | | Regular Expression | PxAxVxP | | Motif Instance | PTACVRP | | Bait Uniprot Accession | P43146 | | Bait Uniprot Identifier | DCC_HUMAN | | Bait Gene Name | DCC | | Sequence Position | 1332-1338 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21353 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9334332, 12626763 | | Comments | Peptide motif that mediates the interaction of the DCC cytoplasmic domain with SIAH2 |
Record No : 49 |
| Instance ID | 11474 | | Regular Expression | [VI]x[VI][VI] | | Motif Instance | IIVL | | Bait Uniprot Accession | Q9UER7 | | Bait Uniprot Identifier | DAXX_HUMAN | | Bait Gene Name | DAXX | | Sequence Position | 7-10 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H; NMR | | Interaction ID | 21474 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19106612, 21383010 | | Comments | N-terminal SUMO-interacting motif (SIM) in Human Death domain-associated protein 6 (DAXX) that mediates strong binding to SUMO1 and is important for transcriptional regulation |
Record No : 50 |
| Instance ID | 11475 | | Regular Expression | [VI]x[VI][VI] | | Motif Instance | IIVL | | Bait Uniprot Accession | Q9UER7 | | Bait Uniprot Identifier | DAXX_HUMAN | | Bait Gene Name | DAXX | | Sequence Position | 733-736 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H; NMR | | Interaction ID | 21475 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17081986, 19106612, 21474068, 21383010 | | Comments | C-terminal SUMO-interacting motif (SIM) in Human Death domain-associated protein 6 (DAXX) that mediates strong binding to SUMO1 and is important for transcriptional regulation |
Record No : 51 |
| Instance ID | 11476 | | Regular Expression | [VI]x[VI][VI] | | Motif Instance | IIVL | | Bait Uniprot Accession | Q9UER7 | | Bait Uniprot Identifier | DAXX_HUMAN | | Bait Gene Name | DAXX | | Sequence Position | 7-10 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H; NMR | | Interaction ID | 21476 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19106612, 21383010 | | Comments | N-terminal SUMO-interacting motif (SIM) in Human Death domain-associated protein 6 (DAXX) that mediates strong binding to SUMO2 and is important for transcriptional regulation |
Record No : 52 |
| Instance ID | 11477 | | Regular Expression | [VI]x[VI][VI] | | Motif Instance | IIVL | | Bait Uniprot Accession | Q9UER7 | | Bait Uniprot Identifier | DAXX_HUMAN | | Bait Gene Name | DAXX | | Sequence Position | 733-736 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H; NMR | | Interaction ID | 21477 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17081986, 19106612, 21383010 | | Comments | C-terminal SUMO-interacting motif (SIM) in Human Death domain-associated protein 6 (DAXX) that mediates strong binding to SUMO2 and is important for transcriptional regulation |
Record No : 53 |
| Instance ID | 11478 | | Regular Expression | [VI]x[VI][VI] | | Motif Instance | IIVL | | Bait Uniprot Accession | Q9UER7 | | Bait Uniprot Identifier | DAXX_HUMAN | | Bait Gene Name | DAXX | | Sequence Position | 7-10 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H | | Interaction ID | 21478 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19106612 | | Comments | N-terminal SUMO-interacting motif (SIM) in Human Death domain-associated protein 6 (DAXX) that mediates strong binding to SUMO3 and is important for transcriptional regulation |
Record No : 54 |
| Instance ID | 11479 | | Regular Expression | [VI]x[VI][VI] | | Motif Instance | IIVL | | Bait Uniprot Accession | Q9UER7 | | Bait Uniprot Identifier | DAXX_HUMAN | | Bait Gene Name | DAXX | | Sequence Position | 733-736 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H | | Interaction ID | 21479 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17081986, 19106612 | | Comments | C-terminal SUMO-interacting motif (SIM) in Human Death domain-associated protein 6 (DAXX) that mediates strong binding to SUMO3 and is important for transcriptional regulation |
Record No : 55 |
| Instance ID | 11582 | | Regular Expression | [ST]x[VLI]$ | | Motif Instance | TTV | | Bait Uniprot Accession | Q8JJ48 | | Bait Uniprot Identifier | DCT1A_XENLA | | Bait Gene Name | dact1-a | | Sequence Position | 816-818 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; NMR | | Interaction ID | 21582 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14636582, 11941372 | | Comments | The C-terminal motif of Xenopus Dapper 1-A (or Frodo) that binds to the PDZ domain of the mouse cytoplasmic protein Dishevelled (Dvl) |
Record No : 56 |
| Instance ID | 11583 | | Regular Expression | [ST]x[VLI]$ | | Motif Instance | TTV | | Bait Uniprot Accession | Q8QG92 | | Bait Uniprot Identifier | DCT1B_XENLA | | Bait Gene Name | dact1-b | | Sequence Position | 822-824 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; NMR | | Interaction ID | 21583 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14636582, 11970895 | | Comments | The C-terminal motif of Xenopus Dapper 1-B that binds to the PDZ domain of the mouse cytoplasmic protein Dishevelled (Dvl) |
Record No : 57 |
| Instance ID | 11646 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | O94850 | | Bait Uniprot Identifier | DEND_HUMAN | | Bait Gene Name | DDN | | Sequence Position | 200-203 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21646 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12559952, 18596123 | | Comments | PPxY motif (200-203) in Dendrin that mediates its interaction with WW domains of KIBRA (WWC1) |
Record No : 58 |
| Instance ID | 11647 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | O94850 | | Bait Uniprot Identifier | DEND_HUMAN | | Bait Gene Name | DDN | | Sequence Position | 224-227 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21647 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12559952, 18596123 | | Comments | PPxY motif (224-227) in Dendrin that mediates its interaction with WW domains of KIBRA (WWC1) |
Record No : 59 |
| Instance ID | 11648 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | O94850 | | Bait Uniprot Identifier | DEND_HUMAN | | Bait Gene Name | DDN | | Sequence Position | 230-233 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21648 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12559952, 18596123 | | Comments | PPxY motif (230-233) in Dendrin that mediates its interaction with WW domains of KIBRA (WWC1) |
Record No : 60 |
| Instance ID | 11649 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | Q08345 | | Bait Uniprot Identifier | DDR1_HUMAN | | Bait Gene Name | DDR1 | | Sequence Position | 481-484 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21649 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18190796 | | Comments | PPxY motif of DDR1 that mediates its interaction with WW domains of KIBRA (WWC1) |
Record No : 61 |
| Instance ID | 11650 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | O94850 | | Bait Uniprot Identifier | DEND_HUMAN | | Bait Gene Name | DDN | | Sequence Position | 200-203 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21650 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16464232 | | Comments | PPxY motif (200-203) in Dendrin that mediates its interaction with WW domains of MAGI-1 |
Record No : 62 |
| Instance ID | 11651 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | O94850 | | Bait Uniprot Identifier | DEND_HUMAN | | Bait Gene Name | DDN | | Sequence Position | 224-227 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21651 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16464232 | | Comments | PPxY motif (224-227) in Dendrin that mediates its interaction with WW domains of MAGI-1 |
Record No : 63 |
| Instance ID | 11652 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | O94850 | | Bait Uniprot Identifier | DEND_HUMAN | | Bait Gene Name | DDN | | Sequence Position | 230-233 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21652 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16464232 | | Comments | PPxY motif (230-233) in Dendrin that mediates its interaction with WW domains of MAGI-1 |
Record No : 64 |
| Instance ID | 11711 | | Regular Expression | PxxPxR | | Motif Instance | PSRPNR | | Bait Uniprot Accession | P21575 | | Bait Uniprot Identifier | DYN1_RAT | | Bait Gene Name | Dnm1 | | Sequence Position | 833-838 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21711 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9238017 | | Comments | The SH3 domain-binding PxxPxR motif in rat Dynamin-1 that binds the SH3 domain of rat Amphiphysin II |
Record No : 65 |
| Instance ID | 11712 | | Regular Expression | PxxPxR | | Motif Instance | PSRPNR | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Sequence Position | 833-838 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21712 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-1 that binds the SH3 domain of human Endophilin-1 (SH3GL2) |
Record No : 66 |
| Instance ID | 11713 | | Regular Expression | PxxPxR | | Motif Instance | PSRPVR | | Bait Uniprot Accession | P50570 | | Bait Uniprot Identifier | DYN2_HUMAN | | Bait Gene Name | DNM2 | | Sequence Position | 832-837 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21713 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-2 that binds the SH3 domain of human Endophilin-1 (SH3GL2) |
Record No : 67 |
| Instance ID | 11714 | | Regular Expression | PxxPxR | | Motif Instance | PSRPNR | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Sequence Position | 833-838 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21714 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-1 that binds the SH3 domain of human Endophilin-2 (SH3GL1) |
Record No : 68 |
| Instance ID | 11715 | | Regular Expression | PxxPxR | | Motif Instance | PSRPVR | | Bait Uniprot Accession | P50570 | | Bait Uniprot Identifier | DYN2_HUMAN | | Bait Gene Name | DNM2 | | Sequence Position | 832-837 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21715 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-2 that binds the SH3 domain of human Endophilin-2 (SH3GL1) |
Record No : 69 |
| Instance ID | 11716 | | Regular Expression | PxxPxR | | Motif Instance | PSRPNR | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Sequence Position | 833-838 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21716 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-1 that binds the SH3 domain of human Endophilin-3 (SH3GL3) |
Record No : 70 |
| Instance ID | 11717 | | Regular Expression | PxxPxR | | Motif Instance | PSRPVR | | Bait Uniprot Accession | P50570 | | Bait Uniprot Identifier | DYN2_HUMAN | | Bait Gene Name | DNM2 | | Sequence Position | 832-837 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21717 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-2 that binds the SH3 domain of human Endophilin-3 (SH3GL3) |
Record No : 71 |
| Instance ID | 11718 | | Regular Expression | PxxPxR | | Motif Instance | PSRPNR | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Sequence Position | 833-838 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21718 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-1 that binds the SH3 domain of human Intersectin-1 |
Record No : 72 |
| Instance ID | 11719 | | Regular Expression | PxxPxR | | Motif Instance | PSRPVR | | Bait Uniprot Accession | P50570 | | Bait Uniprot Identifier | DYN2_HUMAN | | Bait Gene Name | DNM2 | | Sequence Position | 832-837 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21719 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-2 that binds the SH3 domain of human Intersectin-1 |
Record No : 73 |
| Instance ID | 11720 | | Regular Expression | PxxPxR | | Motif Instance | PSRPNR | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Sequence Position | 833-838 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; SPR | | Interaction ID | 21720 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10395825, 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-1 that binds the N-terminal SH3 domain of human adapter protein GRB2 |
Record No : 74 |
| Instance ID | 11721 | | Regular Expression | PxxPxR | | Motif Instance | PSRPVR | | Bait Uniprot Accession | P50570 | | Bait Uniprot Identifier | DYN2_HUMAN | | Bait Gene Name | DNM2 | | Sequence Position | 832-837 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; SPR | | Interaction ID | 21721 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7597091, 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-2 that binds the SH3 domains of human adapter protein GRB2 |
Record No : 75 |
| Instance ID | 11722 | | Regular Expression | PxxPxR | | Motif Instance | PSRPVR | | Bait Uniprot Accession | P50570 | | Bait Uniprot Identifier | DYN2_HUMAN | | Bait Gene Name | DNM2 | | Sequence Position | 832-837 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; SPR | | Interaction ID | 21722 | | Interacting Domain | SH3 domain | | Disease Association(s) | Centronuclear myopathy | | Inhibitor(s) | Unknown | | Reference(s) | 17676042, 15834155 | | Comments | The SH3 domain-binding PxxPxR motif in human Dynamin-2 that binds the SH3 domain of human Amphiphysin |
Record No : 76 |
| Instance ID | 11754 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RRAPAVP | | Bait Uniprot Accession | Q05193 | | Bait Uniprot Identifier | DYN1_HUMAN | | Bait Gene Name | DNM1 | | Sequence Position | 783-789 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; SPR | | Interaction ID | 21754 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15834155, 9539797 | | Comments | The SH3 domain-binding motif in human Dynamin-1 that binds the SH3 domain of human proto-oncogene c-Src |
Record No : 77 |
| Instance ID | 11794 | | Regular Expression | KYxLxP | | Motif Instance | KYLLTP | | Bait Uniprot Accession | Q9H816 | | Bait Uniprot Identifier | DCR1B_HUMAN | | Bait Gene Name | DCLRE1B | | Sequence Position | 503-508 | | Critical Residues | P2; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | X-ray crystallography; Mutational analysis; ITC | | Interaction ID | 21794 | | Interacting Domain | TRF2-TRFH domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18202258 | | Comments | The TRF2-TRFH binding motif in human 5' exonuclease Apollo that interacts with the TRFH domain of human Telomeric repeat-binding factor 2 (TRF2) |
Record No : 78 |
| Instance ID | 11972 | | Regular Expression | NxI | | Motif Instance | NAI | | Bait Uniprot Accession | O94907 | | Bait Uniprot Identifier | DKK1_HUMAN | | Bait Gene Name | DKK1 | | Sequence Position | 40-42 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutational analysis; Competition binding assay; BLI; ELISA | | Interaction ID | 21972 | | Interacting Domain | E1 domain | | Disease Association(s) | Cancer; Alzheimer's disease; Bone disease | | Inhibitor(s) | Unknown | | Reference(s) | 21944579 | | Comments | The NxI peptide motif in the Wnt pathway inhibitor Dickkopf-1 (DKK1) that is important for binding to the E1 propeller domain of Wnt coreceptor LRP6 thereby inhibiting LRP6 interaction with Wnt |
Record No : 79 |
| Instance ID | 11973 | | Regular Expression | NxI | | Motif Instance | NSI | | Bait Uniprot Accession | Q9UBU2 | | Bait Uniprot Identifier | DKK2_HUMAN | | Bait Gene Name | DKK2 | | Sequence Position | 36-38 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; BLI | | Interaction ID | 21973 | | Interacting Domain | E1 domain | | Disease Association(s) | Cancer; Alzheimer's disease; Bone disease | | Inhibitor(s) | Unknown | | Reference(s) | 21944579 | | Comments | The NxI peptide motif in the Wnt pathway inhibitor Dickkopf-2 (DKK2) that is important for binding to the E1 propeller domain of Wnt coreceptor LRP6 thereby inhibiting LRP6 interaction with Wnt |
Record No : 80 |
| Instance ID | 12174 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | VIATEV | | Bait Uniprot Accession | O00548 | | Bait Uniprot Identifier | DLL1_HUMAN | | Bait Gene Name | DLL1 | | Sequence Position | 718-723 | | Critical Residues | P3; P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 22174 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24025447 | | Comments | C-terminal class 1 PDZ-binding motif in human Delta-like protein 1 (DLL1) that binds to the PDZ domain of human Synaptojanin-2-binding protein (SYNJ2BP) |
Record No : 81 |
| Instance ID | 12175 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | VIATEV | | Bait Uniprot Accession | Q9NR61 | | Bait Uniprot Identifier | DLL4_HUMAN | | Bait Gene Name | DLL4 | | Sequence Position | 680-685 | | Critical Residues | P3; P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 22175 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24025447 | | Comments | C-terminal class 1 PDZ-binding motif in human Delta-like protein 4 (DLL4) that binds to the PDZ domain of human Synaptojanin-2-binding protein (SYNJ2BP) |
Record No : 82 |
| Instance ID | 12176 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | VIATEV | | Bait Uniprot Accession | O00548 | | Bait Uniprot Identifier | DLL1_HUMAN | | Bait Gene Name | DLL1 | | Sequence Position | 718-723 | | Critical Residues | P3; P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 22176 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24025447 | | Comments | C-terminal class 1 PDZ-binding motif in human Delta-like protein 1 (DLL1) that binds to the PDZ domain of human Multiple PDZ domain protein (MPDZ/MUPP1) |
Record No : 83 |
| Instance ID | 12177 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | VIATEV | | Bait Uniprot Accession | Q9NR61 | | Bait Uniprot Identifier | DLL4_HUMAN | | Bait Gene Name | DLL4 | | Sequence Position | 680-685 | | Critical Residues | P3; P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 22177 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24025447 | | Comments | C-terminal class 1 PDZ-binding motif in human Delta-like protein 4 (DLL4) that binds to the PDZ domain of human Multiple PDZ domain protein (MPDZ/MUPP1) |
Record No : 84 |
| Instance ID | 12178 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | VIATEV | | Bait Uniprot Accession | O00548 | | Bait Uniprot Identifier | DLL1_HUMAN | | Bait Gene Name | DLL1 | | Sequence Position | 718-723 | | Critical Residues | P3; P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 22178 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24025447 | | Comments | C-terminal class 1 PDZ-binding motif in human Delta-like protein 1 (DLL1) that binds to the PDZ domain of human Membrane-associated guanylate kinase inverted 2 (MAGI2) |
Record No : 85 |
| Instance ID | 12179 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | VIATEV | | Bait Uniprot Accession | Q9NR61 | | Bait Uniprot Identifier | DLL4_HUMAN | | Bait Gene Name | DLL4 | | Sequence Position | 680-685 | | Critical Residues | P3; P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 22179 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24025447 | | Comments | C-terminal class 1 PDZ-binding motif in human Delta-like protein 4 (DLL4) that binds to the PDZ domain of human Membrane-associated guanylate kinase inverted 2 (MAGI2) |
Record No : 86 |
| Instance ID | 12180 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | VIATEV | | Bait Uniprot Accession | O00548 | | Bait Uniprot Identifier | DLL1_HUMAN | | Bait Gene Name | DLL1 | | Sequence Position | 718-723 | | Critical Residues | P3; P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 22180 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24025447 | | Comments | C-terminal class 1 PDZ-binding motif in human Delta-like protein 1 (DLL1) that binds to the PDZ domain of human Membrane-associated guanylate kinase inverted 3 (MAGI3) |
Record No : 87 |
| Instance ID | 12181 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | VIATEV | | Bait Uniprot Accession | Q9NR61 | | Bait Uniprot Identifier | DLL4_HUMAN | | Bait Gene Name | DLL4 | | Sequence Position | 680-685 | | Critical Residues | P3; P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 22181 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24025447 | | Comments | C-terminal class 1 PDZ-binding motif in human Delta-like protein 4 (DLL4) that binds to the PDZ domain of human Membrane-associated guanylate kinase inverted 3 (MAGI3) |
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