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Total : 187 Records
Record No : 1 |
| Instance ID | 10030 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RRSLSVE | | Bait Uniprot Accession | A2ALK8 | | Bait Uniprot Identifier | PTN3_MOUSE | | Bait Gene Name | Ptpn3 | | Sequence Position | 355-361 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20030 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9341175 | | Comments | Phosphorylation-dependent association between Tyrosine-protein phosphatase non-receptor type 3 (Ptpn3) and 14-3-3 protein beta mediated by Ser-359 of Ptpn3 |
Record No : 2 |
| Instance ID | 10031 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RLRRSLP | | Bait Uniprot Accession | Q14432 | | Bait Uniprot Identifier | PDE3A_HUMAN | | Bait Gene Name | PDE3A | | Sequence Position | 424-430 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20031 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16153182 | | Comments | PDE3A (phosphodiesterase 3A) binds directly to BMH1 (the 14-3-3 isoform from Saccharomyces cerevisiae) in a phosphorylation-dependent manner upon phosphorylation of Ser428 |
Record No : 3 |
| Instance ID | 10032 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RLRRSLP | | Bait Uniprot Accession | Q14432 | | Bait Uniprot Identifier | PDE3A_HUMAN | | Bait Gene Name | PDE3A | | Sequence Position | 424-430 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20032 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16153182 | | Comments | PDE3A (phosphodiesterase 3A) binds directly to BMH2 (the 14-3-3 isoform from Saccharomyces cerevisiae) in a phosphorylation-dependent manner upon phosphorylation of Ser428 |
Record No : 4 |
| Instance ID | 10052 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSLSVE | | Bait Uniprot Accession | P26045 | | Bait Uniprot Identifier | PTN3_HUMAN | | Bait Gene Name | PTPN3 | | Sequence Position | 356-361 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20052 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9341175 | | Comments | Phosphorylation-dependent association between human Protein-tyrosine phosphatase H1 (or PTPN3) and 14-3-3 protein beta mediated by pSer-359 of PTPH1 |
Record No : 5 |
| Instance ID | 10053 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RVDSEP | | Bait Uniprot Accession | P26045 | | Bait Uniprot Identifier | PTN3_HUMAN | | Bait Gene Name | PTPN3 | | Sequence Position | 832-837 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20053 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9341175 | | Comments | Phosphorylation-dependent association between human Protein-tyrosine phosphatase H1 (or PTPN3) and 14-3-3 protein beta mediated by pSer-835 of PTPH1 |
Record No : 6 |
| Instance ID | 10079 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSKSAP | | Bait Uniprot Accession | Q02156 | | Bait Uniprot Identifier | KPCE_HUMAN | | Bait Gene Name | PRKCE | | Sequence Position | 343-348 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Chromatography technologies; Peptide binding to perpetrator; ITC; X-ray crystallography | | Interaction ID | 20079 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19662078 | | Comments | Phosphoserine-containing motif (pS346) in human Protein kinase C epsilon type that bind to 14-3-3 protein zeta |
Record No : 7 |
| Instance ID | 10080 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | KALSFD | | Bait Uniprot Accession | Q02156 | | Bait Uniprot Identifier | KPCE_HUMAN | | Bait Gene Name | PRKCE | | Sequence Position | 365-370 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Chromatography technologies; Peptide binding to perpetrator; ITC; X-ray crystallography | | Interaction ID | 20080 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19662078 | | Comments | Phosphoserine-containing motif (pS368) in human Protein kinase C epsilon type that bind to 14-3-3 protein zeta |
Record No : 8 |
| Instance ID | 10121 | | Regular Expression | Fxx[FWY][DE][FY] | | Motif Instance | FRDFDY | | Bait Uniprot Accession | Q16513 | | Bait Uniprot Identifier | PKN2_HUMAN | | Bait Gene Name | PKN2 | | Sequence Position | 974-979 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Affinity chromatography technology; Western blot; Mutation analysis; Y2H; Pull down; SPR; Competition binding | | Interaction ID | 20121 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16219676, 10698939, 10764742 | | Comments | "The hydrophobic motif in the PKC-related kinase, PRK2 (or PKN2), which acts as a ""docking site"" for recruitment of PDK1 and is essential for its phosphorylation by PDK1 in cells" |
Record No : 9 |
| Instance ID | 10122 | | Regular Expression | Fxx[FWY][DE][FY] | | Motif Instance | FEGFEY | | Bait Uniprot Accession | P41743 | | Bait Uniprot Identifier | KPCI_HUMAN | | Bait Gene Name | PRKCI | | Sequence Position | 579-584 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down; Mutation analysis | | Interaction ID | 20122 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10764742 | | Comments | "The hydrophobic motif in PKCiota that acts as a ""docking site"" for the recruitment of PDK1 resulting in phosphorylation at its T-loop site by PDK1 in cells" |
Record No : 10 |
| Instance ID | 10123 | | Regular Expression | Fxx[FWY][DE][FY] | | Motif Instance | FEGFEY | | Bait Uniprot Accession | Q05513 | | Bait Uniprot Identifier | KPCZ_HUMAN | | Bait Gene Name | PRKCZ | | Sequence Position | 575-580 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down; Mutation analysis | | Interaction ID | 20123 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10764742 | | Comments | "The hydrophobic motif in human PKCzeta that acts as a ""docking site"" for the recruitment of PDK1 resulting in phosphorylation at its T-loop site by PDK1 in cells" |
Record No : 11 |
| Instance ID | 10124 | | Regular Expression | Fxx[FWY][DE][FY] | | Motif Instance | FEGFEY | | Bait Uniprot Accession | Q02956 | | Bait Uniprot Identifier | KPCZ_MOUSE | | Bait Gene Name | Prkcz | | Sequence Position | 575-580 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Competition binding; Mutation analysis | | Interaction ID | 20124 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10764742 | | Comments | "The hydrophobic motif in mouse PKCzeta that acts as a ""docking site"" for the recruitment of PDK1 resulting in phosphorylation at its T-loop site by PDK1 in cells" |
Record No : 12 |
| Instance ID | 10125 | | Regular Expression | Fxx[FWY][DE][FY] | | Motif Instance | FLDFDF | | Bait Uniprot Accession | Q16512 | | Bait Uniprot Identifier | PKN1_HUMAN | | Bait Gene Name | PKN1 | | Sequence Position | 932-937 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down; Mutation analysis | | Interaction ID | 20125 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10764742 | | Comments | "The hydrophobic motif in the PKC-related kinase, PRK1 (or PKN1), which acts as a ""docking site"" for recruitment of PDK1 and is essential for its phosphorylation by PDK1 in cells" |
Record No : 13 |
| Instance ID | 10126 | | Regular Expression | FxxF$ | | Motif Instance | FSEF | | Bait Uniprot Accession | P17612 | | Bait Uniprot Identifier | KAPCA_HUMAN | | Bait Gene Name | PRKACA | | Sequence Position | 348-351 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20126 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10698939 | | Comments | "The C-terminal hydrophobic motif in the cAMP-dependent protein kinase catalytic subunit alpha (PRKACA), which acts as a ""docking site"" for recruitment of PDK1" |
Record No : 14 |
| Instance ID | 10129 | | Regular Expression | FxxF$ | | Motif Instance | FTEF | | Bait Uniprot Accession | P05132 | | Bait Uniprot Identifier | KAPCA_MOUSE | | Bait Gene Name | Prkaca | | Sequence Position | 348-351 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Protein kinase assay; Mutation analysis | | Interaction ID | 20129 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15299527, 12372837 | | Comments | "The C-terminal hydrophobic motif in cAMP-dependent protein kinase catalytic subunit alpha which acts as a ""docking site"" for its phosphorylation by Phosphoinositide-dependent kinase-1 (PDK-1)" |
Record No : 15 |
| Instance ID | 10157 | | Regular Expression | xRxxLxx[LIVM]x | | Motif Instance | NRKPLTVLN | | Bait Uniprot Accession | P53350 | | Bait Uniprot Identifier | PLK1_HUMAN | | Bait Gene Name | PLK1 | | Sequence Position | 336-344 | | Critical Residues | P2; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20157 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14734534 | | Comments | APCC-binding Destruction motif (DBox) in human Polo-like kinase 1 (PLK1) recognised by Cdh1, co-activator protein for the anaphase-promoting ubiquitin ligase complex APC/C |
Record No : 16 |
| Instance ID | 10164 | | Regular Expression | xKENx | | Motif Instance | DKENG | | Bait Uniprot Accession | O95997 | | Bait Uniprot Identifier | PTTG1_HUMAN | | Bait Gene Name | PTTG1 | | Sequence Position | 8-12 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20164 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11179223 | | Comments | KEN-box motif in human Securin/PTTG protein that mediates its degradation by the APC/C coactivator fzr (fizzy-related/cdh1/hct1) |
Record No : 17 |
| Instance ID | 10286 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RNLL | | Bait Uniprot Accession | Q99640 | | Bait Uniprot Identifier | PMYT1_HUMAN | | Bait Gene Name | PKMYT1 | | Sequence Position | 486-489 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20286 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10373560 | | Comments | The cyclin recognition site (RxL motif) found in human Myt1 kinase that interacts with cyclin B1 and thereby induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes |
Record No : 18 |
| Instance ID | 10308 | | Regular Expression | [^P]x[KR]xTQT | | Motif Instance | EDKSTQT | | Bait Uniprot Accession | P22363 | | Bait Uniprot Identifier | PHOSP_RABVC | | Bait Gene Name | P | | Sequence Position | 142-148 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20308 | | Interacting Domain | Dynein light chain type 1 | | Disease Association(s) | Rabies | | Inhibitor(s) | Unknown | | Reference(s) | 17438267 | | Comments | The dynein light chain 8 binding motif of rabies virus phosphoprotein that binds to mouse DLC-8, the interaction being essential for RV pathogenesis |
Record No : 19 |
| Instance ID | 10313 | | Regular Expression | xAxGPPx{2,3}Yx | | Motif Instance | QAQGPPYPTYP | | Bait Uniprot Accession | Q9WU78 | | Bait Uniprot Identifier | PDC6I_MOUSE | | Bait Gene Name | Pdcd6ip | | Sequence Position | 798-808 | | Critical Residues | P4; P5; P6; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | gal4 vp16 complementation; Competition binding | | Interaction ID | 20313 | | Interacting Domain | EABR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20176808 | | Comments | Cep55 EABR-binding motif in mouse Alix (Programmed cell death 6-interacting protein or Pdcd6ip) that mediates binding to the EABR domain of Cep55 |
Record No : 20 |
| Instance ID | 10314 | | Regular Expression | xAxGPPx{2,3}Yx | | Motif Instance | QAQGPPYPTYP | | Bait Uniprot Accession | Q8WUM4 | | Bait Uniprot Identifier | PDC6I_HUMAN | | Bait Gene Name | PDCD6IP | | Sequence Position | 797-807 | | Critical Residues | P4; P5; P6; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Colocalization; Alanine scanning; Mutation analysis; Cosedimentation; ITC; Pull down; Competition binding; SPR; X-ray crystallography; gal4 vp16 complementation | | Interaction ID | 20314 | | Interacting Domain | EABR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17853893, 18948538, 20176808 | | Comments | Cep55 EABR-binding motif in human ALIX (Programmed cell death 6-interacting protein or PDCD6IP) that mediates binding to the EABR domain of CEP55 |
Record No : 21 |
| Instance ID | 10355 | | Regular Expression | xNPFx | | Motif Instance | GNPFG | | Bait Uniprot Accession | Q9Z0W5 | | Bait Uniprot Identifier | PACN1_RAT | | Bait Gene Name | Pacsin1 | | Sequence Position | 363-367 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP; Pull down; Classical fluorescence spectroscopy; Y2H | | Interaction ID | 20355 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15930129 | | Comments | EH domain-containing protein 1 associates with rat Pacsin1/Syndapin-I via EH domain/NPF interactions through the NPF motif (363-367) of syndapin I |
Record No : 22 |
| Instance ID | 10357 | | Regular Expression | xNPFx | | Motif Instance | ANPFE | | Bait Uniprot Accession | Q9Z0W5 | | Bait Uniprot Identifier | PACN1_RAT | | Bait Gene Name | Pacsin1 | | Sequence Position | 375-379 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP; Pull down; Classical fluorescence spectroscopy; Far Western blotting; Y2H | | Interaction ID | 20357 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15930129 | | Comments | EH domain-containing protein 1 associates with rat Pacsin1/Syndapin-I via EH domain/NPF interactions through the NPF motif (375-379) of syndapin I |
Record No : 23 |
| Instance ID | 10358 | | Regular Expression | xNPFx | | Motif Instance | YNPFE | | Bait Uniprot Accession | Q9QY17 | | Bait Uniprot Identifier | PACN2_RAT | | Bait Gene Name | Pacsin2 | | Sequence Position | 363-367 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP; Pull down; Far Western blotting | | Interaction ID | 20358 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15930129, 15371016 | | Comments | EH domain-containing protein 1 associates with rat Pacsin2/Syndapin-II via EH domain/NPF interactions through the NPF motif (363-367) of syndapin II |
Record No : 24 |
| Instance ID | 10360 | | Regular Expression | xNPFx | | Motif Instance | NNPFS | | Bait Uniprot Accession | Q9QY17 | | Bait Uniprot Identifier | PACN2_RAT | | Bait Gene Name | Pacsin2 | | Sequence Position | 406-410 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP; Pull down; Far Western blotting | | Interaction ID | 20360 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15930129, 15371016 | | Comments | EH domain-containing protein 1 associates with rat Pacsin2/Syndapin-II via EH domain/NPF interactions through the NPF motif (406-410) of syndapin II |
Record No : 25 |
| Instance ID | 10361 | | Regular Expression | xNPFx | | Motif Instance | SNPFD | | Bait Uniprot Accession | Q9QY17 | | Bait Uniprot Identifier | PACN2_RAT | | Bait Gene Name | Pacsin2 | | Sequence Position | 418-422 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP; Pull down; Far Western blotting | | Interaction ID | 20361 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15930129, 15371016 | | Comments | EH domain-containing protein 1 associates with rat Pacsin2/Syndapin-II via EH domain/NPF interactions through the NPF motif (418-422) of syndapin II |
Record No : 26 |
| Instance ID | 10366 | | Regular Expression | xNPFx | | Motif Instance | LNPFL | | Bait Uniprot Accession | O55012 | | Bait Uniprot Identifier | PICAL_RAT | | Bait Gene Name | Picalm | | Sequence Position | 429-433 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Classical fluorescence spectroscopy | | Interaction ID | 20366 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15182197 | | Comments | EHD2 interacts with rat Clathrin assembly lymphoid myeloid leukemia protein (Calm) through the NPF motif (429-433) of rCALM |
Record No : 27 |
| Instance ID | 10367 | | Regular Expression | xNPFx | | Motif Instance | PNPFG | | Bait Uniprot Accession | O55012 | | Bait Uniprot Identifier | PICAL_RAT | | Bait Gene Name | Picalm | | Sequence Position | 626-630 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Classical fluorescence spectroscopy | | Interaction ID | 20367 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15182197 | | Comments | EHD2 interacts with rat Clathrin assembly lymphoid myeloid leukemia protein (Calm) through the NPF motif (626-630) of rCALM |
Record No : 28 |
| Instance ID | 10384 | | Regular Expression | xNPFx | | Motif Instance | LNPFL | | Bait Uniprot Accession | Q13492 | | Bait Uniprot Identifier | PICAL_HUMAN | | Bait Gene Name | PICALM | | Sequence Position | 436-440 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 20384 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12807910 | | Comments | Asn-Pro-Phe motif (436-440) in human AP180-2 (CALM) that is responsible for the interaction with Eps15 homology (EH) domain of Epidermal growth factor receptor substrate 15 (EPS15) |
Record No : 29 |
| Instance ID | 10385 | | Regular Expression | xNPFx | | Motif Instance | PNPFG | | Bait Uniprot Accession | Q13492 | | Bait Uniprot Identifier | PICAL_HUMAN | | Bait Gene Name | PICALM | | Sequence Position | 638-642 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 20385 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12807910 | | Comments | Asn-Pro-Phe motif (638-642) in human AP180-2 (CALM) that is responsible for the interaction with Eps15 homology (EH) domain of Epidermal growth factor receptor substrate 15 (EPS15) |
Record No : 30 |
| Instance ID | 10405 | | Regular Expression | x[FYH]x[IVM][^WFYP][^WFYP][ILM][ILMV]x | | Motif Instance | SYSISGILG | | Bait Uniprot Accession | Q02548 | | Bait Uniprot Identifier | PAX5_HUMAN | | Bait Gene Name | PAX5 | | Sequence Position | 178-186 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20405 | | Interacting Domain | WD domain, G-beta repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10811620 | | Comments | The octapeptide motif in human Paired box protein Pax-5 that binds to the WD40 domain of the mouse Grg4 protein (Transducin-like enhancer protein 4 or Tle4) |
Record No : 31 |
| Instance ID | 10460 | | Regular Expression | [DE]HxY | | Motif Instance | DHDY | | Bait Uniprot Accession | Q5VV67 | | Bait Uniprot Identifier | PPRC1_HUMAN | | Bait Gene Name | PPRC1 | | Sequence Position | 1295-1298 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20460 | | Interacting Domain | Galactose oxidase, central domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18343819 | | Comments | Human PGC-1-related coactivator complexes with HCF-1 through its HCF-1 binding site |
Record No : 32 |
| Instance ID | 10489 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | ERAAVAIQSQFRKFQKKKAG | | Bait Uniprot Accession | P48539 | | Bait Uniprot Identifier | PCP4_HUMAN | | Bait Gene Name | PCP4 | | Sequence Position | 40-59 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | FRET; NMR | | Interaction ID | 20489 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17991744 | | Comments | The IQ motif of human Brain-specific polypeptide PEP-19 that binds preferentially to the C-domain of Calmodulin (CaM) |
Record No : 33 |
| Instance ID | 10510 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | FKAAALIQRWYRRYVARLE | | Bait Uniprot Accession | O14830 | | Bait Uniprot Identifier | PPE2_HUMAN | | Bait Gene Name | PPEF2 | | Sequence Position | 20-38 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Competition binding; SPR; Y2H; Western blot | | Interaction ID | 20510 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12051765, 11754840 | | Comments | The Calmodulin binding IQ motif in the N-terminal domain of human Protein Ser/Thr phosphatase PPEF2 interacts with murine Calmodulin (CaM) |
Record No : 34 |
| Instance ID | 10513 | | Regular Expression | [LM]YPx[LI] | | Motif Instance | MYPRL | | Bait Uniprot Accession | Q00202 | | Bait Uniprot Identifier | PACC_EMENI | | Bait Gene Name | pacC | | Sequence Position | 454-458 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Pull down(GST tag) | | Interaction ID | 20513 | | Interacting Domain | V-domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12588984 | | Comments | The regulation of gene expression by ambient pH in Aspergillus nidulans involves the zinc finger transcription factor pacC/RIM101 that interacts with pH-response regulator protein palA/RIM20, a component of the fungal ambient pH signal transduction pathway, through its LYPxL motif (454-458) |
Record No : 35 |
| Instance ID | 10517 | | Regular Expression | [LM]YPx[LI] | | Motif Instance | MYPTL | | Bait Uniprot Accession | Q00202 | | Bait Uniprot Identifier | PACC_EMENI | | Bait Gene Name | pacC | | Sequence Position | 661-665 | | Critical Residues | P2; P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Pull down(GST tag) | | Interaction ID | 20517 | | Interacting Domain | V-domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12588984 | | Comments | The regulation of gene expression by ambient pH in Aspergillus nidulans involves the zinc finger transcription factor pacC/RIM101 that interacts with pH-response regulator protein palA/RIM20, a component of the fungal ambient pH signal transduction pathway, through its LYPxL motif (661-665) |
Record No : 36 |
| Instance ID | 10518 | | Regular Expression | [LM]YPx[LI] | | Motif Instance | MYPTL | | Bait Uniprot Accession | Q00202 | | Bait Uniprot Identifier | PACC_EMENI | | Bait Gene Name | pacC | | Sequence Position | 661-665 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20518 | | Interacting Domain | V-domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12588984 | | Comments | The LYPxL motif (661-665) of Aspergillus nidulans pH-response transcription factor pacC/RIM101 that interacts with human ALIX (AIP1/PDCD6IP) |
Record No : 37 |
| Instance ID | 10552 | | Regular Expression | [LMV]PxLE | | Motif Instance | MPDLE | | Bait Uniprot Accession | Q15185 | | Bait Uniprot Identifier | TEBP_HUMAN | | Bait Gene Name | PTGES3 | | Sequence Position | 156-160 | | Critical Residues | P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Mutation analysis; Western blot; RNA interference; Co-IP; Mass spectrometry; Co-IP | | Interaction ID | 20552 | | Interacting Domain | MYND domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23413029 | | Comments | The MYND-type Zinc Finger of human Prolyl hydroxylase domain protein 2 (PHD2/EGLN1) binds a PxLE motif found in human HSP90 co-chaperone p23 (PTGES3) |
Record No : 38 |
| Instance ID | 10556 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | VLRKLLK | | Bait Uniprot Accession | Q90ZL7 | | Bait Uniprot Identifier | Q90ZL7_DANRE | | Bait Gene Name | prox1a | | Sequence Position | 69-75 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Site-directed mutagenesis; Y2H | | Interaction ID | 20556 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14517294 | | Comments | The NR box motif (LXXLL) of Zebrafish Prox1, a prospero-related homeodomain protein, interacts with and modulates the transcriptional activity of Ff1b (nr5a4), the zebrafish homologue of SF-1 |
Record No : 39 |
| Instance ID | 10558 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | ELKALLQ | | Bait Uniprot Accession | Q9UQ80 | | Bait Uniprot Identifier | PA2G4_HUMAN | | Bait Gene Name | PA2G4 | | Sequence Position | 353-359 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20558 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12165860 | | Comments | The NR box motif (LXXLL) of human ErbB-3 binding protein (EBP1)/ Proliferation-associated protein 2G4 (PA2G4), that is necessary for binding the human Androgen receptor (AR) |
Record No : 40 |
| Instance ID | 10569 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | LLKKLLL | | Bait Uniprot Accession | Q9UBK2 | | Bait Uniprot Identifier | PRGC1_HUMAN | | Bait Gene Name | PPARGC1A | | Sequence Position | 143-149 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20569 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18469005, 12502716 | | Comments | The functional interaction between the human Peroxisome proliferator-activated receptor gamma (PPARG) and its coactivator PPAR-gamma coactivator 1-alpha (PPARGC1A/PGC-1) is mediated by the LXXLL motif of PGC-1 |
Record No : 41 |
| Instance ID | 10585 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | SNLNPNAKEFVPG | | Bait Uniprot Accession | Q9BPZ3 | | Bait Uniprot Identifier | PAIP2_HUMAN | | Bait Gene Name | PAIP2 | | Sequence Position | 109-121 | | Critical Residues | P3; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Co-IP; SPR; ITC; NMR; Mutation analysis; Pull down; X-ray crystallography | | Interaction ID | 20585 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16601676, 14685257, 20096703 | | Comments | The PABP-interacting motif 2 (PAM2) in human PABP-interacting protein 2 (PAIP2) that mediates binding to the MLLE domain of Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) |
Record No : 42 |
| Instance ID | 10586 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | SVLNPMADEFVPR | | Bait Uniprot Accession | Q9VG13 | | Bait Uniprot Identifier | Q9VG13_DROME | | Bait Gene Name | Paip2 | | Sequence Position | 103-115 | | Critical Residues | P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Far Western blotting; Co-IP; Pull down | | Interaction ID | 20586 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14729960 | | Comments | The PABP-interacting motif 2 (PAM2) in the Drosophila melanogaster Paip2 (dPaip2) that mediates binding to the MLLE domain of Drosophila Polyadenylate-binding protein (pAbp) |
Record No : 43 |
| Instance ID | 10587 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | SKLSVNAPEFYPS | | Bait Uniprot Accession | Q9H074 | | Bait Uniprot Identifier | PAIP1_HUMAN | | Bait Gene Name | PAIP1 | | Sequence Position | 126-138 | | Critical Residues | P3; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | ITC; NMR; SPR; Pull down; Mutation analysis; Far Western blotting; Co-IP | | Interaction ID | 20587 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16554297, 14685257, 11997512 | | Comments | The PABP-interacting motif 2 (PAM2) in human PABP-interacting protein 1 (PAIP1) that mediates binding to the MLLE domain of Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) |
Record No : 44 |
| Instance ID | 10588 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | SNLNPDAKEFIPG | | Bait Uniprot Accession | Q9ULR5 | | Bait Uniprot Identifier | PAI2B_HUMAN | | Bait Gene Name | PAIP2B | | Sequence Position | 108-120 | | Critical Residues | P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Pull down; Far Western blotting; Co-IP | | Interaction ID | 20588 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16804161 | | Comments | The PABP-interacting motif 2 (PAM2) in human PABP-interacting protein 2B (PAIP2B) that mediates binding to the MLLE domain of Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) |
Record No : 45 |
| Instance ID | 10608 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | QTPNPTASEFIPK | | Bait Uniprot Accession | Q58A45 | | Bait Uniprot Identifier | PAN3_HUMAN | | Bait Gene Name | PAN3 | | Sequence Position | 284-296 | | Critical Residues | P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP; Pull down; ITC; NMR | | Interaction ID | 20608 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18056425, 17595167 | | Comments | The PAM2 motif in human PAB-dependent poly(A)-specific ribonuclease subunit PAN3 that mediates binding to the MLLE domain of Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) |
Record No : 46 |
| Instance ID | 10611 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QGTLESFFKR | | Bait Uniprot Accession | P47110 | | Bait Uniprot Identifier | DPOD3_YEAST | | Bait Gene Name | POL32 | | Sequence Position | 338-347 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20611 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14594808 | | Comments | The C-terminal PCNA binding PIP box motif of POL32, the third subunit of Saccharomyces cerevisiae DNA polymerase delta (Pol delta), that mediates interactions with the carboxyl-terminal region of the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30) |
Record No : 47 |
| Instance ID | 10618 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QVSITGFFQR | | Bait Uniprot Accession | Q15054 | | Bait Uniprot Identifier | DPOD3_HUMAN | | Bait Gene Name | POLD3 | | Sequence Position | 456-465 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20618 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15576034 | | Comments | The PCNA binding PIP box motif in human DNA polymerase delta subunit 3 (POLD3) that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin) |
Record No : 48 |
| Instance ID | 10627 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | AEDSFL | | Bait Uniprot Accession | P09619 | | Bait Uniprot Identifier | PGFRB_HUMAN | | Bait Gene Name | PDGFRB | | Sequence Position | 1101-1106 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Far Western blotting; Mutation analysis; X-ray crystallography | | Interaction ID | 20627 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11882663 | | Comments | The amino-terminal PDZ domain of human Na(+)/H(+) exchange regulatory cofactor NHERF1 (SLC9A3R1), referred to as PDZ1, binds with high affinity to the C-terminal PDZ domain-binding motif of human Platelet-derived growth factor receptor beta |
Record No : 49 |
| Instance ID | 10672 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | LTASEV | | Bait Uniprot Accession | Q66T02 | | Bait Uniprot Identifier | PKHG5_MOUSE | | Bait Gene Name | Plekhg5 | | Sequence Position | 1068-1073 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20672 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16467373 | | Comments | C-terminal class 1 PDZ-binding motif in mouse Synectin-binding RhoA exchange factor (Syx/Plekhg5) that binds to the PDZ domain of mouse PDZ adaptor protein synectin (Gipc1) leading to targeting of Syx to the plasma membrane |
Record No : 50 |
| Instance ID | 10678 | | Regular Expression | xxx[VLIFY]x[ACVILF]$ | | Motif Instance | VRTYSC | | Bait Uniprot Accession | Q13136 | | Bait Uniprot Identifier | LIPA1_HUMAN | | Bait Gene Name | PPFIA1 | | Sequence Position | 1197-1202 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20678 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12493751 | | Comments | The C-terminal class 2 PDZ-binding motif of human Liprin-alpha-1 (PPFIA1) that binds to the sixth PDZ domain of rat Grip1 |
Record No : 51 |
| Instance ID | 10684 | | Regular Expression | xxx[VLIFY]x[ACVILF]$ | | Motif Instance | FHQFYI | | Bait Uniprot Accession | P49768 | | Bait Uniprot Identifier | PSN1_HUMAN | | Bait Gene Name | PSEN1 | | Sequence Position | 462-467 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Y2H; Colocalization; Co-IP; Pull down | | Interaction ID | 20684 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10551805, 11083918 | | Comments | The C-terminal class 2 PDZ-binding motif of human Presenilin-1 (PSEN1) that binds to the PDZ domain of human Adapter protein X11alpha (APBA1) |
Record No : 52 |
| Instance ID | 10693 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | NSRVTFS | | Bait Uniprot Accession | Q12972 | | Bait Uniprot Identifier | PP1R8_HUMAN | | Bait Gene Name | PPP1R8 | | Sequence Position | 198-204 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Phosphatase assay | | Interaction ID | 20693 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12657641 | | Comments | The RVXF motif of human Nuclear inhibitor of protein phosphatase 1 (NIPP1) that mediates binding to the catalytic subunit of protein phosphatase 1 (PP1c) |
Record No : 53 |
| Instance ID | 10694 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | KTKVKFD | | Bait Uniprot Accession | Q90623 | | Bait Uniprot Identifier | MYPT1_CHICK | | Bait Gene Name | PPP1R12A | | Sequence Position | 33-39 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20694 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15164081 | | Comments | The RVXF motif of chicken Protein phosphatase 1 regulatory subunit 12A (PPP1R12A) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CB) |
Record No : 54 |
| Instance ID | 10696 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | DRKKIQFS | | Bait Uniprot Accession | Q9UD71 | | Bait Uniprot Identifier | PPR1B_HUMAN | | Bait Gene Name | PPP1R1B | | Sequence Position | 5-12 | | Critical Residues | P2; P3; P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20696 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10075680, 9108011 | | Comments | The RVXF motif of human DARPP-32 (PPP1R1B) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) at a site removed from the active site and that this interaction is not directly involved in inhibition of enzyme activity |
Record No : 55 |
| Instance ID | 10697 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | KRKSVTWP | | Bait Uniprot Accession | Q96QC0 | | Bait Uniprot Identifier | PP1RA_HUMAN | | Bait Gene Name | PPP1R10 | | Sequence Position | 395-402 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20697 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12574161 | | Comments | The RVXF motif of human PNUTS, Phosphatase 1 NUclear Targeting Subunit (PPP1R10), that mediates high affinity binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) and inhibition of PP1 activity |
Record No : 56 |
| Instance ID | 10702 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | SRKIHFS | | Bait Uniprot Accession | O35274 | | Bait Uniprot Identifier | NEB2_RAT | | Bait Gene Name | Ppp1r9b | | Sequence Position | 446-452 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Far Western blotting; Co-IP | | Interaction ID | 20702 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20305656, 10585469 | | Comments | The RVXF motif (446-452) of rat Neurabin-2/Spinophilin/Protein phosphatase 1 regulatory subunit 9B (Ppp1r9b) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) |
Record No : 57 |
| Instance ID | 10703 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | KGRVRFM | | Bait Uniprot Accession | O35274 | | Bait Uniprot Identifier | NEB2_RAT | | Bait Gene Name | Ppp1r9b | | Sequence Position | 573-579 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20703 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20305656 | | Comments | The RVXF motif (573-579) of rat Neurabin-2/Spinophilin/Protein phosphatase 1 regulatory subunit 9B (Ppp1r9b) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) |
Record No : 58 |
| Instance ID | 10704 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | TRRVSFA | | Bait Uniprot Accession | Q16821 | | Bait Uniprot Identifier | PPR3A_HUMAN | | Bait Gene Name | PPP1R3A | | Sequence Position | 61-67 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 20704 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9155014 | | Comments | The RVXF motif of human Protein phosphatase 1 regulatory subunit 3A (PPP1R3A) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) |
Record No : 59 |
| Instance ID | 10706 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | NRKIKFS | | Bait Uniprot Accession | O35867 | | Bait Uniprot Identifier | NEB1_RAT | | Bait Gene Name | Ppp1r9a | | Sequence Position | 455-461 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Chromatography technologies; Affinity chromatography technology; Far Western blotting; Y2H; Co-IP; Mutation analysis | | Interaction ID | 20706 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10504266, 10585469 | | Comments | The RVXF motif of rat Neurabin-1/Protein phosphatase 1 regulatory subunit 9A (Ppp1r9a) that mediates binding to rat PP1-alpha catalytic subunit (Ppp1ca) and inhibits PP1 activity |
Record No : 60 |
| Instance ID | 10723 | | Regular Expression | xP[TS]APx | | Motif Instance | EPSAPS | | Bait Uniprot Accession | Q8WUM4 | | Bait Uniprot Identifier | PDC6I_HUMAN | | Bait Gene Name | PDCD6IP | | Sequence Position | 716-721 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Co-IP; Mutation analysis | | Interaction ID | 20723 | | Interacting Domain | UEV domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17853893 | | Comments | The UEV Domain binding P[TS]AP motif in Human PDCD6-interacting protein (PDCD6IP)/AIP1/ALIX that mediates binding to the UEV domain of human Tumor susceptibility gene 101 protein (TSG101) |
Record No : 61 |
| Instance ID | 10792 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | IRCDE | | Bait Uniprot Accession | Q13029 | | Bait Uniprot Identifier | PRDM2_HUMAN | | Bait Gene Name | PRDM2 | | Sequence Position | 310-314 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20792 | | Interacting Domain | B domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 7538672 | | Comments | The Rb-binding LxCxE motif in the Human Zinc finger protein RIZ (PRDM2) that mediates binding to the human retinoblastoma protein (RB) suggesting a role for RIZ in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma |
Record No : 62 |
| Instance ID | 10840 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGRGS | | Bait Uniprot Accession | P16471 | | Bait Uniprot Identifier | PRLR_HUMAN | | Bait Gene Name | PRLR | | Sequence Position | 348-353 | | Critical Residues | P2 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding to perpetrator; Protein kinase assay; Co-IP | | Interaction ID | 20840 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15082796 | | Comments | The pituitary hormone prolactin (PRL) promotes interaction between Human Prolactin receptor (PRLR) and the F-box/WD repeat-containing protein beta-TrCP (BTRC), substrate recognition subunit of the SCF ubiquitin ligase complex, depending on phosphorylation of serine 349 |
Record No : 63 |
| Instance ID | 10843 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGRGDS | | Bait Uniprot Accession | Q53EL6 | | Bait Uniprot Identifier | PDCD4_HUMAN | | Bait Gene Name | PDCD4 | | Sequence Position | 70-76 | | Critical Residues | P2 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Protein kinase assay; Mass spectrometry | | Interaction ID | 20843 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17053147 | | Comments | The physical interaction between the tumor suppressor Programmed cell death protein 4 (PDCD4) and the F-box/WD repeat-containing protein beta-TrCP (BTRC) requires the DSGXX(X)S degron and is stimulated by phosphorylation on Ser67 of PDCD4 |
Record No : 64 |
| Instance ID | 10855 | | Regular Expression | (Y)xNx | | Motif Instance | YSNA | | Bait Uniprot Accession | P09619 | | Bait Uniprot Identifier | PGFRB_HUMAN | | Bait Gene Name | PDGFRB | | Sequence Position | 716-719 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20855 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8940081 | | Comments | The SH2 domain of Human Epidermal growth factor receptor GRB-7 can directly bind to the autophosphorylated PDGF beta-receptor (PDGFRB) on Tyr-716 |
Record No : 65 |
| Instance ID | 10862 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YAEI | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Sequence Position | 397-400 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Protein kinase assay; Co-IP; Mutation analysis; Western blot | | Interaction ID | 20862 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 7739563 | | Comments | Proto-oncogene c-Src, through its SH2 domain, stably associates with the focal adhesion kinase p125FAK phosphorylated at Tyr-397 |
Record No : 66 |
| Instance ID | 10878 | | Regular Expression | [RKY]xxPxxP | | Motif Instance | KPRPPRP | | Bait Uniprot Accession | P27986 | | Bait Uniprot Identifier | P85A_HUMAN | | Bait Gene Name | PIK3R1 | | Sequence Position | 88-94 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Pull down; Competition binding | | Interaction ID | 20878 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8294442 | | Comments | Proline-rich SH3-binding sequence (88-94) in human PI3-kinase regulatory subunit p85-alpha that associates with the SH3 domain of human Proto-oncogene c-Fyn |
Record No : 67 |
| Instance ID | 10882 | | Regular Expression | PxxPx[KR] | | Motif Instance | PAPPMR | | Bait Uniprot Accession | P35465 | | Bait Uniprot Identifier | PAK1_RAT | | Bait Gene Name | Pak1 | | Sequence Position | 13-18 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Pull down(GST tag); SPR | | Interaction ID | 20882 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10805734 | | Comments | The N-terminal sequence of rat Serine/threonine-protein kinase Pak1/Alpha-PAK that allows it to bind to the SH3 domain of the rat adaptor protein Nck1 |
Record No : 68 |
| Instance ID | 10883 | | Regular Expression | PxxPx[KR] | | Motif Instance | PPLPER | | Bait Uniprot Accession | P29352 | | Bait Uniprot Identifier | PTN22_MOUSE | | Bait Gene Name | Ptpn22 | | Sequence Position | 614-619 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; Mutation analysis | | Interaction ID | 20883 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11685249, 9582365 | | Comments | Mouse C-terminal Src kinase (Csk) takes part in a highly specific, high affinity interaction via its Src homology 3 (SH3) domain with the proline-enriched PEST domain of mouse tyrosine phosphatase PEP in hematopoietic cells |
Record No : 69 |
| Instance ID | 10885 | | Regular Expression | PxxPx[KR] | | Motif Instance | PTLPHR | | Bait Uniprot Accession | P53112 | | Bait Uniprot Identifier | PEX14_YEAST | | Bait Gene Name | PEX14 | | Sequence Position | 87-92 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography; Y2H; Mutation analysis | | Interaction ID | 20885 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12453410, 10087260 | | Comments | The SH3 domain of Saccharomyces cerevisiae Peroxisomal membrane protein PAS20/Pex13p binds to PPII-helical ligand from yeast Peroxisomal membrane protein Pex14p |
Record No : 70 |
| Instance ID | 10887 | | Regular Expression | PxxPx[KR] | | Motif Instance | PALPPK | | Bait Uniprot Accession | P27986 | | Bait Uniprot Identifier | P85A_HUMAN | | Bait Gene Name | PIK3R1 | | Sequence Position | 305-310 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Competition binding; Pull down | | Interaction ID | 20887 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8294442 | | Comments | Proline-rich SH3-binding sequence (305-310) in human PI3-kinase regulatory subunit p85-alpha that associates with the SH3 domain of human Proto-oncogene c-Fyn |
Record No : 71 |
| Instance ID | 10888 | | Regular Expression | PxxPx[KR] | | Motif Instance | PPKPPK | | Bait Uniprot Accession | P27986 | | Bait Uniprot Identifier | P85A_HUMAN | | Bait Gene Name | PIK3R1 | | Sequence Position | 308-313 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Pull down | | Interaction ID | 20888 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8294442 | | Comments | Proline-rich SH3-binding sequence (308-313) in human PI3-kinase regulatory subunit p85-alpha that associates with the SH3 domain of human Proto-oncogene c-Fyn |
Record No : 72 |
| Instance ID | 10890 | | Regular Expression | PxxPx[KR] | | Motif Instance | PPKPSR | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Sequence Position | 750-755 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Mutation analysis; Pull down; Y2H | | Interaction ID | 20890 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8662921, 7479864 | | Comments | The SH3 domain of Mouse p130cas (CRK-associated substrate) or Bcar1 binds to a proline-rich sequence present in the C terminus of Mouse pp125FAK/ Focal adhesion kinase 1 (Fak1)/ Protein-tyrosine kinase 2 (Ptk2), a kinase which is activated upon cell adhesion, and this interaction is likely to be functionally important in integrin mediated signal transduction |
Record No : 73 |
| Instance ID | 10895 | | Regular Expression | PxxPx[KR] | | Motif Instance | PAPPMR | | Bait Uniprot Accession | Q13153 | | Bait Uniprot Identifier | PAK1_HUMAN | | Bait Gene Name | PAK1 | | Sequence Position | 13-18 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Y2H; Pull down; Mutation analysis | | Interaction ID | 20895 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8798379 | | Comments | The association between human NCK adaptor protein 1 (NCK1) and human Serine/threonine-protein kinase PAK1 is mediated by the second SH3 domain of NCK1 and a proline-rich sequence in the amino terminus of PAK1 |
Record No : 74 |
| Instance ID | 10916 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | APTAVVLPH | | Bait Uniprot Accession | Q16633 | | Bait Uniprot Identifier | OBF1_HUMAN | | Bait Gene Name | POU2AF1 | | Sequence Position | 46-54 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag); Mammalian two-hybrid assay; Classical fluorescence spectroscopy | | Interaction ID | 20916 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11483518 | | Comments | The PxAxVxP motif in human B-cell-specific coactivator OBF-1/BOB-1 (POU2AF1) that confer a high-affinity binding to human E3 ubiquitin-protein ligase SIAH1 |
Record No : 75 |
| Instance ID | 10917 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | APTAVVLPH | | Bait Uniprot Accession | Q16633 | | Bait Uniprot Identifier | OBF1_HUMAN | | Bait Gene Name | POU2AF1 | | Sequence Position | 46-54 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag); Mammalian two-hybrid assay; Classical fluorescence spectroscopy | | Interaction ID | 20917 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11483518 | | Comments | The PxAxVxP motif in human B-cell-specific coactivator OBF-1/BOB-1 (POU2AF1) that confer a high-affinity binding to human E3 ubiquitin-protein ligase SIAH2 |
Record No : 76 |
| Instance ID | 10921 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | RPVAMVRPT | | Bait Uniprot Accession | Q27934 | | Bait Uniprot Identifier | PHYL_DROME | | Bait Gene Name | phyl | | Sequence Position | 115-123 | | Critical Residues | P6; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutation analysis; Co-IP; Pull down | | Interaction ID | 20921 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16615911, 12626763 | | Comments | The PxAxVxP motif in Drosophila Phyllopod (phyl) protein that mediates binding to mouse E3 ubiquitin-protein ligase Siah1a |
Record No : 77 |
| Instance ID | 10923 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | PPRALVLPH | | Bait Uniprot Accession | Q86TG7 | | Bait Uniprot Identifier | PEG10_HUMAN | | Bait Gene Name | PEG10 | | Sequence Position | 253-261 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Co-IP | | Interaction ID | 20923 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12810624 | | Comments | Human Retrotransposon-derived protein PEG10 (paternally expressed gene 10) associates with human E3 ubiquitin-protein ligase SIAH1, a mediator of apoptosis, and overexpression of PEG10 decreases the cell death mediated by SIAH1 |
Record No : 78 |
| Instance ID | 10951 | | Regular Expression | [ED][LIV]NNN[^P] | | Motif Instance | ELNNNL | | Bait Uniprot Accession | Q96IZ0 | | Bait Uniprot Identifier | PAWR_HUMAN | | Bait Gene Name | PAWR | | Sequence Position | 68-73 | | Critical Residues | P3; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20951 | | Interacting Domain | SPRY domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20561531 | | Comments | Substrate recognition site for the SPRY domain of human SPRY domain-containing SOCS box protein 1 (SPSB1) identified in human Prostate apoptosis response 4 protein (PAR4/PAWR) |
Record No : 79 |
| Instance ID | 10952 | | Regular Expression | [ED][LIV]NNN[^P] | | Motif Instance | ELNNNL | | Bait Uniprot Accession | Q96IZ0 | | Bait Uniprot Identifier | PAWR_HUMAN | | Bait Gene Name | PAWR | | Sequence Position | 68-73 | | Critical Residues | P3; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20952 | | Interacting Domain | SPRY domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20561531 | | Comments | Substrate recognition site for the SPRY domain of human SPRY domain-containing SOCS box protein 2 (SPSB2) identified in human Prostate apoptosis response 4 protein (PAR4/PAWR) |
Record No : 80 |
| Instance ID | 10953 | | Regular Expression | [ED][LIV]NNN[^P] | | Motif Instance | ELNNNL | | Bait Uniprot Accession | Q96IZ0 | | Bait Uniprot Identifier | PAWR_HUMAN | | Bait Gene Name | PAWR | | Sequence Position | 68-73 | | Critical Residues | P3; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20953 | | Interacting Domain | SPRY domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20561531 | | Comments | Substrate recognition site for the SPRY domain of human SPRY domain-containing SOCS box protein 4 (SPSB4) identified in human Prostate apoptosis response 4 protein (PAR4/PAWR) |
Record No : 81 |
| Instance ID | 10960 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | VIDLT | | Bait Uniprot Accession | O75925 | | Bait Uniprot Identifier | PIAS1_HUMAN | | Bait Gene Name | PIAS1 | | Sequence Position | 459-463 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Y2H; Pull down(GST tag) | | Interaction ID | 20960 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16524884 | | Comments | The SUMO-interacting motif (SIM) of human E3 SUMO-protein ligase PIAS1 that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 82 |
| Instance ID | 10965 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | VIDLT | | Bait Uniprot Accession | Q9Y6X2 | | Bait Uniprot Identifier | PIAS3_HUMAN | | Bait Gene Name | PIAS3 | | Sequence Position | 447-451 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Pull down; Y2H | | Interaction ID | 20965 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16524884 | | Comments | The SUMO-interacting motif (SIM) of human E3 SUMO-protein ligase PIAS3 that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 83 |
| Instance ID | 10970 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | VIDLT | | Bait Uniprot Accession | O75928 | | Bait Uniprot Identifier | PIAS2_HUMAN | | Bait Gene Name | PIAS2 | | Sequence Position | 469-473 | | Critical Residues | P1; P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | ITC; NMR; Alanine scanning; Mutation analysis | | Interaction ID | 20970 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16204249, 15388847, 16524884 | | Comments | The SUMO-interacting motif (SIM) of human E3 SUMO-protein ligase PIAS2 that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 84 |
| Instance ID | 10971 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | VVDLT | | Bait Uniprot Accession | Q8N2W9 | | Bait Uniprot Identifier | PIAS4_HUMAN | | Bait Gene Name | PIAS4 | | Sequence Position | 465-469 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Y2H; Mutation analysis; Co-IP | | Interaction ID | 20971 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16524884, 21199872 | | Comments | The SUMO-interacting motif (SIM) of human E3 SUMO-protein ligase PIAS4 that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 85 |
| Instance ID | 10972 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | VVISSSEDSD | | Bait Uniprot Accession | P29590 | | Bait Uniprot Identifier | PML_HUMAN | | Bait Gene Name | PML | | Sequence Position | 557-566 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Western blot; Co-IP; NMR; Mutation analysis | | Interaction ID | 20972 | | Interacting Domain | Unknown | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17081985, 21192925 | | Comments | The SUMO-interacting motif (SIM) of human Promyelocytic leukemia protein (PML) that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 86 |
| Instance ID | 11032 | | Regular Expression | [FY]xLxP | | Motif Instance | FTLKP | | Bait Uniprot Accession | Q96BK5 | | Bait Uniprot Identifier | PINX1_HUMAN | | Bait Gene Name | PINX1 | | Sequence Position | 289-293 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC | | Interaction ID | 21032 | | Interacting Domain | TRFH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18202258 | | Comments | The telomeric repeat binding factor (TRF) homology (TRFH) domain of human Telomeric repeat-binding factor 1 (TERF1/PIN2/TRF1) recognizes and directly interacts with the [Y/F]XL motif in human PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1) and regulates telomere maintenance |
Record No : 87 |
| Instance ID | 11085 | | Regular Expression | xxx([ST])Px | | Motif Instance | KKASPE | | Bait Uniprot Accession | P29590 | | Bait Uniprot Identifier | PML_HUMAN | | Bait Gene Name | PML | | Sequence Position | 400-405 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Mutation analysis | | Interaction ID | 21085 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18039859 | | Comments | Degradation of the human tumor suppressor Promyelocytic leukemia protein (PML) by human Peptidyl-prolyl cis-trans isomerase PIN1, in a phosphorylation-dependent manner via the Ser-403-Pro motif in PML, contributes to the oncogenic transformation and cancer phenotype |
Record No : 88 |
| Instance ID | 11086 | | Regular Expression | xxx([ST])Px | | Motif Instance | GPPSPR | | Bait Uniprot Accession | P29590 | | Bait Uniprot Identifier | PML_HUMAN | | Bait Gene Name | PML | | Sequence Position | 524-529 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Mutation analysis | | Interaction ID | 21086 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18039859 | | Comments | Degradation of the human tumor suppressor Promyelocytic leukemia protein (PML) by human Peptidyl-prolyl cis-trans isomerase PIN1, in a phosphorylation-dependent manner via the Ser-527-Pro motif in PML, contributes to the oncogenic transformation and cancer phenotype |
Record No : 89 |
| Instance ID | 11096 | | Regular Expression | xxx([ST])Px | | Motif Instance | FAFSPP | | Bait Uniprot Accession | Q01860 | | Bait Uniprot Identifier | PO5F1_HUMAN | | Bait Gene Name | POU5F1 | | Sequence Position | 9-14 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Phosphatase assay; Pull down; Mutation analysis | | Interaction ID | 21096 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21296877 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Ser(12)-Pro motif of human Octamer-binding protein 4 (OCT4/POU5F1) and functions as a putative regulator of the induction and maintenance of pluripotency |
Record No : 90 |
| Instance ID | 11110 | | Regular Expression | xxx([ST])Px | | Motif Instance | ARSSPE | | Bait Uniprot Accession | P29590 | | Bait Uniprot Identifier | PML_HUMAN | | Bait Gene Name | PML | | Sequence Position | 502-507 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Mutation analysis | | Interaction ID | 21110 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18039859 | | Comments | Degradation of the human tumor suppressor Promyelocytic leukemia protein (PML) by human Peptidyl-prolyl cis-trans isomerase PIN1, in a phosphorylation-dependent manner via the Ser-505-Pro motif in PML, contributes to the oncogenic transformation and cancer phenotype |
Record No : 91 |
| Instance ID | 11111 | | Regular Expression | xxx([ST])Px | | Motif Instance | KAVSPP | | Bait Uniprot Accession | P29590 | | Bait Uniprot Identifier | PML_HUMAN | | Bait Gene Name | PML | | Sequence Position | 515-520 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Mutation analysis | | Interaction ID | 21111 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18039859 | | Comments | Degradation of the human tumor suppressor Promyelocytic leukemia protein (PML) by human Peptidyl-prolyl cis-trans isomerase PIN1, in a phosphorylation-dependent manner via the Ser-518-Pro motif in PML, contributes to the oncogenic transformation and cancer phenotype |
Record No : 92 |
| Instance ID | 11130 | | Regular Expression | xxx([ST])Px | | Motif Instance | QEISPP | | Bait Uniprot Accession | Q05397 | | Bait Uniprot Identifier | FAK1_HUMAN | | Bait Gene Name | PTK2 | | Sequence Position | 907-912 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Classical fluorescence spectroscopy; Western blot; Pull down; Mutation analysis | | Interaction ID | 21130 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19595712 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the Ser-910-Pro motif of human Focal adhesion kinase 1 (FAK1) and may thereby play a role in Ras-related tumor metastasis |
Record No : 93 |
| Instance ID | 11148 | | Regular Expression | xxx([ST])Px | | Motif Instance | QEISPP | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Sequence Position | 907-912 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Protein kinase assay; Pull down; Classical fluorescence spectroscopy; Mutation analysis; Western blot | | Interaction ID | 21148 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19595712 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 interacts with the Ser-910-Pro motif of mouse Focal adhesion kinase 1 (Fak1/Ptk2) and may thereby play a role in Ras-related tumor metastasis |
Record No : 94 |
| Instance ID | 11150 | | Regular Expression | xxx([ST])Px | | Motif Instance | EPASPP | | Bait Uniprot Accession | P37231 | | Bait Uniprot Identifier | PPARG_HUMAN | | Bait Gene Name | PPARG | | Sequence Position | 81-86 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; SPR; Pull down; Mutation analysis; Co-IP | | Interaction ID | 21150 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19996102 | | Comments | The WW domain of human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Ser-84-Pro motif of human Peroxisome proliferator-activated receptor gamma (PPARG) and thereby regulates macrophage function |
Record No : 95 |
| Instance ID | 11153 | | Regular Expression | xxx([ST])Px | | Motif Instance | AASTPR | | Bait Uniprot Accession | P29590 | | Bait Uniprot Identifier | PML_HUMAN | | Bait Gene Name | PML | | Sequence Position | 406-411 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Mutation analysis | | Interaction ID | 21153 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18039859 | | Comments | Degradation of the human tumor suppressor Promyelocytic leukemia protein (PML) by human Peptidyl-prolyl cis-trans isomerase PIN1, in a phosphorylation-dependent manner via the Thr-409-Pro motif in PML, contributes to the oncogenic transformation and cancer phenotype |
Record No : 96 |
| Instance ID | 11154 | | Regular Expression | xxx([ST])Px | | Motif Instance | SPRSPV | | Bait Uniprot Accession | P29590 | | Bait Uniprot Identifier | PML_HUMAN | | Bait Gene Name | PML | | Sequence Position | 527-532 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Mutation analysis | | Interaction ID | 21154 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18039859 | | Comments | Degradation of the human tumor suppressor Promyelocytic leukemia protein (PML) by human Peptidyl-prolyl cis-trans isomerase PIN1, in a phosphorylation-dependent manner via the Ser-530-Pro motif in PML, contributes to the oncogenic transformation and cancer phenotype |
Record No : 97 |
| Instance ID | 11161 | | Regular Expression | [LV][DE][^P][LM][LM][^P][^P]L[^P] | | Motif Instance | LDRLLLELN | | Bait Uniprot Accession | P49024 | | Bait Uniprot Identifier | PAXI_CHICK | | Bait Gene Name | PXN | | Sequence Position | 145-153 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | NMR | | Interaction ID | 21161 | | Interacting Domain | FAT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11909967 | | Comments | Chicken Paxillin (PXN) interacts with Chicken Focal adhesion kinase 1 (FAK1/PTK2) through its LD motif |
Record No : 98 |
| Instance ID | 11162 | | Regular Expression | [LV][DE][^P][LM][LM][^P][^P]L[^P] | | Motif Instance | LDELMASLS | | Bait Uniprot Accession | P49023 | | Bait Uniprot Identifier | PAXI_HUMAN | | Bait Gene Name | PXN | | Sequence Position | 266-274 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21162 | | Interacting Domain | FAT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14527389 | | Comments | Human Paxillin (PXN) interacts with human Focal adhesion kinase 1 (FAK1/PTK2) through its LD motif (266-274) |
Record No : 99 |
| Instance ID | 11163 | | Regular Expression | [LV][DE][^P][LM][LM][^P][^P]L[^P] | | Motif Instance | LDELMASLS | | Bait Uniprot Accession | P49023 | | Bait Uniprot Identifier | PAXI_HUMAN | | Bait Gene Name | PXN | | Sequence Position | 266-274 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21163 | | Interacting Domain | FAT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19358827 | | Comments | Human Paxillin (PXN) interacts with human Protein tyrosine kinase 2 beta (PTK2B)/ Focal adhesion kinase 2 (FAK2) through its LD motif |
Record No : 100 |
| Instance ID | 11164 | | Regular Expression | [LV][DE][^P][LM][LM][^P][^P]L[^P] | | Motif Instance | LDALLADLE | | Bait Uniprot Accession | P49023 | | Bait Uniprot Identifier | PAXI_HUMAN | | Bait Gene Name | PXN | | Sequence Position | 4-12 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Co-IP; Peptide binding to perpetrator; Pull down(His tag); Pull down(GST tag); Competition binding; Mutation analysis; Colocalization | | Interaction ID | 21164 | | Interacting Domain | FAT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20489202, 11304546, 10330411, 11134073 | | Comments | Human Paxillin (PXN) interacts with human Focal adhesion kinase 1 (FAK1/PTK2) through its LD motif (4-12) |
Record No : 101 |
| Instance ID | 11168 | | Regular Expression | xx(T)xx[ILV]x | | Motif Instance | PDTLEIY | | Bait Uniprot Accession | P34217 | | Bait Uniprot Identifier | PIN4_YEAST | | Bait Gene Name | PIN4 | | Sequence Position | 303-309 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Mutation analysis; Co-IP; Y2H | | Interaction ID | 21168 | | Interacting Domain | FHA domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16231900, 15024067 | | Comments | The FHA domain of yeast Serine/threonine-protein kinase RAD53 binds to the phosphothreonine motif from the yeast RNA-binding protein PIN4/MDT1 |
Record No : 102 |
| Instance ID | 11205 | | Regular Expression | [ED][ED][ED]x[IV]Yx | | Motif Instance | EEEHVYS | | Bait Uniprot Accession | Q8VI36 | | Bait Uniprot Identifier | PAXI_MOUSE | | Bait Gene Name | Pxn | | Sequence Position | 113-119 | | Critical Residues | P2; P3; P5; P6 | | Motif PTM(s) | Phosphorylation at Tyr-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed Mutagenesis; In-vitro assay using fluorogenic peptide probes | | Interaction ID | 21205 | | Interacting Domain | Catalytic domain of Ptprz | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21890632 | | Comments | Consensus sequence for association with protein-tyrosine phosphatase receptor type zeta in mouse Paxillin |
Record No : 103 |
| Instance ID | 11235 | | Regular Expression | [ST]x[VL]D | | Motif Instance | SGLD | | Bait Uniprot Accession | Q13610 | | Bait Uniprot Identifier | PWP1_HUMAN | | Bait Gene Name | PWP1 | | Sequence Position | 389-392 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21235 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22876914 | | Comments | Novel internal motif identified in human PWP1 that is recognized by human Glutaminase-interacting protein (GIP), also known as Tax-interacting protein 1 (TIP1) or Tax1-binding protein 3 (TAX1BP3), composed almost exclusively of a single PDZ domain |
Record No : 104 |
| Instance ID | 11264 | | Regular Expression | VATSPI | | Motif Instance | VATSPI | | Bait Uniprot Accession | Q13153 | | Bait Uniprot Identifier | PAK1_HUMAN | | Bait Gene Name | PAK1 | | Sequence Position | 217-222 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; SPR; Fluorescence anisotropy; Stopped-flow fluorescence spectroscopy | | Interaction ID | 21264 | | Interacting Domain | Unknown | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15193260, 20889982 | | Comments | Putative noncanonical motif in human p21-activated kinase 1 (PAK 1) that may mediate its interaction with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 105 |
| Instance ID | 11265 | | Regular Expression | VATSPI | | Motif Instance | VATSPI | | Bait Uniprot Accession | Q13153 | | Bait Uniprot Identifier | PAK1_HUMAN | | Bait Gene Name | PAK1 | | Sequence Position | 217-222 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; SPR; Fluorescence anisotropy; Stopped-flow fluorescence spectroscopy | | Interaction ID | 21265 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15845372, 20889982 | | Comments | Putative noncanonical motif in human p21-activated kinase 1 (PAK 1) that may mediate its interaction with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 106 |
| Instance ID | 11276 | | Regular Expression | [KR]xTQTx | | Motif Instance | KSTQTT | | Bait Uniprot Accession | P22363 | | Bait Uniprot Identifier | PHOSP_RABVC | | Bait Gene Name | P | | Sequence Position | 144-149 | | Critical Residues | P1; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21276 | | Interacting Domain | Unknown | | Disease Association(s) | Rabies encephalomyelitis | | Inhibitor(s) | Unknown | | Reference(s) | 11513870, 11024152, 11024151 | | Comments | The LC8 dynein light chain binding motif in the rabies virus P protein that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 107 |
| Instance ID | 11277 | | Regular Expression | TASQTM | | Motif Instance | TASQTM | | Bait Uniprot Accession | B2MUM6 | | Bait Uniprot Identifier | B2MUM6_ASF | | Bait Gene Name | p54 | | Sequence Position | 158-163 | | Critical Residues | P1; P3; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21277 | | Interacting Domain | Unknown | | Disease Association(s) | Swine fever | | Inhibitor(s) | Unknown | | Reference(s) | 11559815 | | Comments | The LC8 dynein light chain binding motif in the p54 protein of African swine fever virus that interacts with the pig 8 kDa Dynein light chain 1 (DYNLL1/LC8) |
Record No : 108 |
| Instance ID | 11344 | | Regular Expression | RPVAxVxPxxR | | Motif Instance | RPVAMVRPTVR | | Bait Uniprot Accession | Q27934 | | Bait Uniprot Identifier | PHYL_DROME | | Bait Gene Name | phyl | | Sequence Position | 115-125 | | Critical Residues | P6; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Site-directed mutagenesis; Peptide binding assay; SPR | | Interaction ID | 21344 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12626763, 16615911 | | Comments | Peptide motif that mediates the interaction of phyl with Mouse Siah1a |
Record No : 109 |
| Instance ID | 11345 | | Regular Expression | RPVAxVxPxxR | | Motif Instance | RPVAMVRPTVR | | Bait Uniprot Accession | Q27934 | | Bait Uniprot Identifier | PHYL_DROME | | Bait Gene Name | phyl | | Sequence Position | 115-125 | | Critical Residues | P6; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Site-directed mutagenesis; Peptide binding assay; SPR | | Interaction ID | 21345 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12626763 | | Comments | Peptide motif that mediates the interaction of phyl with Mouse Siah2 |
Record No : 110 |
| Instance ID | 11346 | | Regular Expression | RPVAxVxPxxR | | Motif Instance | RPVAMVRPTVR | | Bait Uniprot Accession | Q27934 | | Bait Uniprot Identifier | PHYL_DROME | | Bait Gene Name | phyl | | Sequence Position | 115-125 | | Critical Residues | P6; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Peptide binding assay; SPR | | Interaction ID | 21346 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12626763 | | Comments | Peptide motif that mediates the interaction of phyl with Drosophila SINA |
Record No : 111 |
| Instance ID | 11347 | | Regular Expression | RPVAxVxPxxR | | Motif Instance | RPVAMVIPARR | | Bait Uniprot Accession | Q9QXS1 | | Bait Uniprot Identifier | PLEC_MOUSE | | Bait Gene Name | Plec | | Sequence Position | 102-112 | | Critical Residues | P6; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Peptide binding assay; SPR | | Interaction ID | 21347 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12626763 | | Comments | Degradation signal or “degron” motif in mouse plectin-1 which mediates binding to the Siah1a ubiquitin ligase |
Record No : 112 |
| Instance ID | 11348 | | Regular Expression | RPVAxVxPxxR | | Motif Instance | RPVAMVIPARR | | Bait Uniprot Accession | Q9QXS1 | | Bait Uniprot Identifier | PLEC_MOUSE | | Bait Gene Name | Plec | | Sequence Position | 102-112 | | Critical Residues | P6; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Peptide binding assay; SPR | | Interaction ID | 21348 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12626763 | | Comments | Degradation signal or “degron” motif in mouse plectin-1 which mediates binding to the Siah2 ubiquitin ligase |
Record No : 113 |
| Instance ID | 11349 | | Regular Expression | RPVAxVxPxxR | | Motif Instance | RPVAMVIPARR | | Bait Uniprot Accession | Q9QXS1 | | Bait Uniprot Identifier | PLEC_MOUSE | | Bait Gene Name | Plec | | Sequence Position | 102-112 | | Critical Residues | P6; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Peptide binding assay; SPR | | Interaction ID | 21349 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12626763 | | Comments | Peptide motif that mediates its interaction of mouse plectin-1 with Drosophila SINA |
Record No : 114 |
| Instance ID | 11356 | | Regular Expression | PxAxVxP | | Motif Instance | PTAVVLP | | Bait Uniprot Accession | Q16633 | | Bait Uniprot Identifier | OBF1_HUMAN | | Bait Gene Name | POU2AF1 | | Sequence Position | 47-53 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis | | Interaction ID | 21356 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11483517, 11483518, 12626763 | | Comments | Peptide motif that mediates the interaction of OBF-1 with SIAH1 |
Record No : 115 |
| Instance ID | 11357 | | Regular Expression | PxAxVxP | | Motif Instance | PTAVVLP | | Bait Uniprot Accession | Q16633 | | Bait Uniprot Identifier | OBF1_HUMAN | | Bait Gene Name | POU2AF1 | | Sequence Position | 47-53 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis | | Interaction ID | 21357 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11483517, 11483518, 12626763 | | Comments | Peptide motif that mediates the interaction of OBF-1 with SIAH2 |
Record No : 116 |
| Instance ID | 11469 | | Regular Expression | [RK]Sx[ST]xP | | Motif Instance | RSKSAP | | Bait Uniprot Accession | Q02156 | | Bait Uniprot Identifier | KPCE_HUMAN | | Bait Gene Name | PRKCE | | Sequence Position | 343-348 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Extended conformation | | Experimental Method(s) | X-ray crystallography; Sequence based prediction | | Interaction ID | 21469 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8601312, 19662078 | | Comments | 14-3-3 binding motif in PRKCE (pS-346) which binds 14-3-3 protein zeta |
Record No : 117 |
| Instance ID | 11471 | | Regular Expression | [RK]Sx[ST]xP | | Motif Instance | KCSTWP | | Bait Uniprot Accession | P16471 | | Bait Uniprot Identifier | PRLR_HUMAN | | Bait Gene Name | PRLR | | Sequence Position | 412-417 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21471 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12819209 | | Comments | Motif mediating interaction between PRLR and 14-3-3 protein zeta |
Record No : 118 |
| Instance ID | 11472 | | Regular Expression | [RK]Sx[ST]xP | | Motif Instance | KCSTWP | | Bait Uniprot Accession | P16471 | | Bait Uniprot Identifier | PRLR_HUMAN | | Bait Gene Name | PRLR | | Sequence Position | 412-417 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21472 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12819209 | | Comments | Motif mediating interaction between PRLR and 14-3-3 protein gamma |
Record No : 119 |
| Instance ID | 11473 | | Regular Expression | [VI]x[VI][VI] | | Motif Instance | VVVI | | Bait Uniprot Accession | P29590 | | Bait Uniprot Identifier | PML_HUMAN | | Bait Gene Name | PML | | Sequence Position | 556-559 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR | | Interaction ID | 21473 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15388847 | | Comments | Residues in the PML Protein involved in direct association with SUMO-1 |
Record No : 120 |
| Instance ID | 11484 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TKV | | Bait Uniprot Accession | P60484 | | Bait Uniprot Identifier | PTEN_HUMAN | | Bait Gene Name | PTEN | | Sequence Position | 401-403 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Phosphorylation at Thr-P1 | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag); Y2H | | Interaction ID | 21484 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10646847, 15951562 | | Comments | C-terminal tail of PTEN that interacts with the second PDZ domain of hDLG |
Record No : 121 |
| Instance ID | 11485 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TKV | | Bait Uniprot Accession | P60484 | | Bait Uniprot Identifier | PTEN_HUMAN | | Bait Gene Name | PTEN | | Sequence Position | 401-403 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag); Y2H | | Interaction ID | 21485 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15951562 | | Comments | C-terminal tail of PTEN that interacts with the PDZ domain of MAST1 |
Record No : 122 |
| Instance ID | 11486 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TKV | | Bait Uniprot Accession | P60484 | | Bait Uniprot Identifier | PTEN_HUMAN | | Bait Gene Name | PTEN | | Sequence Position | 401-403 | | Critical Residues | P2; P3 | | Motif PTM(s) | Phosphorylation at Thr-P1 | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag); Y2H | | Interaction ID | 21486 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10646847, 15951562 | | Comments | C-terminal tail of PTEN that interacts with the single PDZ domain from hMAST205 |
Record No : 123 |
| Instance ID | 11487 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TKV | | Bait Uniprot Accession | P60484 | | Bait Uniprot Identifier | PTEN_HUMAN | | Bait Gene Name | PTEN | | Sequence Position | 401-403 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag); Y2H | | Interaction ID | 21487 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15951562 | | Comments | C-terminal tail of PTEN that interacts with the PDZ domain of MAST3 |
Record No : 124 |
| Instance ID | 11488 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TKV | | Bait Uniprot Accession | P60484 | | Bait Uniprot Identifier | PTEN_HUMAN | | Bait Gene Name | PTEN | | Sequence Position | 401-403 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21488 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15629897, 15951562 | | Comments | C-terminal tail of PTEN that interacts with the second PDZ domain of MAGI1 |
Record No : 125 |
| Instance ID | 11489 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TKV | | Bait Uniprot Accession | P60484 | | Bait Uniprot Identifier | PTEN_HUMAN | | Bait Gene Name | PTEN | | Sequence Position | 401-403 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag); Y2H | | Interaction ID | 21489 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10760291, 15951562 | | Comments | C-terminal tail of PTEN that interacts with PDZ-2/MAGI-2 |
Record No : 126 |
| Instance ID | 11490 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TKV | | Bait Uniprot Accession | P60484 | | Bait Uniprot Identifier | PTEN_HUMAN | | Bait Gene Name | PTEN | | Sequence Position | 401-403 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag); Y2H | | Interaction ID | 21490 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10748157, 15951562 | | Comments | C-terminal tail of PTEN that interacts with the PDZ domain 2 of MAGI3 to position PTEN phosphatase to specific subcellular locations that are involved with the regulation of cell proliferation and survival |
Record No : 127 |
| Instance ID | 11633 | | Regular Expression | [ED][VL]Dx[ML][ML]x[DE]L | | Motif Instance | ELDRLLLEL | | Bait Uniprot Accession | P49024 | | Bait Uniprot Identifier | PAXI_CHICK | | Bait Gene Name | PXN | | Sequence Position | 144-152 | | Critical Residues | P3; P4; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21633 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8922390 | | Comments | Adhesion-targeting Motif (LD motif 2) in Paxillin that mediates its interaction with Vinculin for paxillin localization to focal adhesions |
Record No : 128 |
| Instance ID | 11634 | | Regular Expression | [ED][VL]Dx[ML][ML]x[DE]L | | Motif Instance | ELDRLLLEL | | Bait Uniprot Accession | P49024 | | Bait Uniprot Identifier | PAXI_CHICK | | Bait Gene Name | PXN | | Sequence Position | 144-152 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21634 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8922390 | | Comments | Adhesion-targeting Motif (LD motif 2) in Paxillin that mediates its interaction with focal adhesion kinase (FAK) [also known as Protein-tyrosine kinase 2 (PTK2)] for paxillin localization to focal adhesions |
Record No : 129 |
| Instance ID | 11635 | | Regular Expression | [ED][VL]Dx[ML][ML]x[DE]L | | Motif Instance | ELDELMASL | | Bait Uniprot Accession | P49024 | | Bait Uniprot Identifier | PAXI_CHICK | | Bait Gene Name | PXN | | Sequence Position | 266-274 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21635 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8922390 | | Comments | Adhesion-targeting Motif (LD motif 4) in Paxillin that mediates its interaction with focal adhesion kinase (FAK) [also known as Protein-tyrosine kinase 2 (PTK2)] for paxillin localization to focal adhesions |
Record No : 130 |
| Instance ID | 11641 | | Regular Expression | DLDALLAD | | Motif Instance | DLDALLAD | | Bait Uniprot Accession | P49024 | | Bait Uniprot Identifier | PAXI_CHICK | | Bait Gene Name | PXN | | Sequence Position | 3-10 | | Critical Residues | P1; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21641 | | Interacting Domain | Unknown | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 9467941, 10814581 | | Comments | Leucine-rich peptides termed charged leucine motifs found on the cellular focal adhesion protein paxillin that bind to E6 oncoprotein of Bovine Papillomavirus Type 1 |
Record No : 131 |
| Instance ID | 11668 | | Regular Expression | D[ST]xL$ | | Motif Instance | DTSL | | Bait Uniprot Accession | P47900 | | Bait Uniprot Identifier | P2RY1_HUMAN | | Bait Gene Name | P2RY1 | | Sequence Position | 370-373 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Ligand Overlay Assay | | Interaction ID | 21668 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9671706 | | Comments | C-terminal PDZ domain-binding motif in human P2Y purinoceptor 1 (P2Y1) that mediates binding to the first PDZ domain of the Na+/H+ exchanger regulatory factor (NHERF) |
Record No : 132 |
| Instance ID | 11733 | | Regular Expression | PxxPxR | | Motif Instance | PPKPPR | | Bait Uniprot Accession | P35831 | | Bait Uniprot Identifier | PTN12_MOUSE | | Bait Gene Name | Ptpn12 | | Sequence Position | 333-338 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Ligand Overlay Assay | | Interaction ID | 21733 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9135065 | | Comments | The SH3 domain-binding PxxPxR motif 1 (333-338) in murine protein tyrosine phosphatase-PEST (MPTP-PEST) that binds to the SH3 domains of human adapter protein GRB2 |
Record No : 133 |
| Instance ID | 11734 | | Regular Expression | PxxPxR | | Motif Instance | PPLPER | | Bait Uniprot Accession | P35831 | | Bait Uniprot Identifier | PTN12_MOUSE | | Bait Gene Name | Ptpn12 | | Sequence Position | 675-680 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Ligand Overlay Assay | | Interaction ID | 21734 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9135065 | | Comments | The SH3 domain-binding PxxPxR motif 4 (675-680) in murine protein tyrosine phosphatase-PEST (MPTP-PEST) that binds to the SH3 domains of human adapter protein GRB2 |
Record No : 134 |
| Instance ID | 11735 | | Regular Expression | PxxPxR | | Motif Instance | PPKPSR | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Sequence Position | 750-755 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21735 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11278488 | | Comments | The SH3 domain-binding PxxPxR motif (750-755) in mouse Focal adhesion kinase 1 that binds the SH3 domain of Tyrosine-protein kinase transforming oncoprotein v-Src, a gene product of Rous sarcoma virus |
Record No : 135 |
| Instance ID | 11736 | | Regular Expression | PxxPxR | | Motif Instance | PKKPPR | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Sequence Position | 911-916 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21736 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11278488 | | Comments | The SH3 domain-binding PxxPxR motif (911-916) in mouse Focal adhesion kinase 1 that binds the SH3 domain of Tyrosine-protein kinase transforming oncoprotein v-Src, a gene product of Rous sarcoma virus |
Record No : 136 |
| Instance ID | 11737 | | Regular Expression | PxxPxR | | Motif Instance | PPKPSR | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Sequence Position | 750-755 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H | | Interaction ID | 21737 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 7479864 | | Comments | The SH3 domain-binding PxxPxR motif (750-755) in mouse Focal adhesion kinase 1 that binds the SH3 domain of a v-Crk-associated tyrosine kinase substrate, p130Cas (Breast cancer anti-estrogen resistance protein 1 or Bcar1). This motif, and its interaction it mediates, may be important in the invasion of host cells by Salmonella typhimurium |
Record No : 137 |
| Instance ID | 11738 | | Regular Expression | PxxPxR | | Motif Instance | PKKPPR | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Sequence Position | 911-916 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H | | Interaction ID | 21738 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 9038154 | | Comments | The SH3 domain-binding PxxPxR motif (911-916) in mouse Focal adhesion kinase 1 that binds the SH3 domain of a v-Crk-associated tyrosine kinase substrate, p130Cas (Breast cancer anti-estrogen resistance protein 1 or Bcar1) |
Record No : 138 |
| Instance ID | 11756 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RALPSIP | | Bait Uniprot Accession | P34152 | | Bait Uniprot Identifier | FAK1_MOUSE | | Bait Gene Name | Ptk2 | | Sequence Position | 368-374 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21756 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11278488 | | Comments | The SH3 domain-binding motif in mouse Focal adhesion kinase 1 that binds the SH3 domain of Tyrosine-protein kinase transforming oncoprotein v-Src, a gene product of Rous sarcoma virus |
Record No : 139 |
| Instance ID | 11757 | | Regular Expression | [RK]xxPxxP | | Motif Instance | KPLPPLP | | Bait Uniprot Accession | P08018 | | Bait Uniprot Identifier | PBS2_YEAST | | Bait Gene Name | PBS2 | | Sequence Position | 93-99 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SH3-domain array binding assay; Peptide binding assay | | Interaction ID | 21757 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14668868, 9180081 | | Comments | Interaction of the SH3 domain from the yeast high osmolarity signaling protein SHO1 with a proline-rich motif from the MAP kinase kinase PBS2 |
Record No : 140 |
| Instance ID | 11777 | | Regular Expression | PxPxPR | | Motif Instance | PTPAPR | | Bait Uniprot Accession | Q8WUM4 | | Bait Uniprot Identifier | PDC6I_HUMAN | | Bait Gene Name | PDCD6IP | | Sequence Position | 740-745 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21777 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 10858458 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human Programmed cell death 6-interacting protein that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 141 |
| Instance ID | 11791 | | Regular Expression | FxLxP | | Motif Instance | FTLKP | | Bait Uniprot Accession | Q96BK5 | | Bait Uniprot Identifier | PINX1_HUMAN | | Bait Gene Name | PINX1 | | Sequence Position | 289-293 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; ITC | | Interaction ID | 21791 | | Interacting Domain | TRF1-TRFH domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18202258 | | Comments | The TRF1-TRFH binding motif in human PINX1 (PIN2/TERF1-interacting telomerase inhibitor 1) that interacts with the TRFH domain of human Telomeric repeat-binding factor 1 (TRF1) |
Record No : 142 |
| Instance ID | 11793 | | Regular Expression | KYxLxP | | Motif Instance | KYNLKP | | Bait Uniprot Accession | Q96QC0 | | Bait Uniprot Identifier | PP1RA_HUMAN | | Bait Gene Name | PPP1R10 | | Sequence Position | 235-240 | | Critical Residues | P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Peptide binding assay (Fluorescence polarization); BiFC assay | | Interaction ID | 21793 | | Interacting Domain | TRF2-TRFH domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19287395 | | Comments | The TRF2-TRFH binding motif in human PNUTS (Phosphatase 1 nuclear targeting subunit) that interacts with the TRFH domain of human Telomeric repeat-binding factor 2 (TRF2) |
Record No : 143 |
| Instance ID | 11800 | | Regular Expression | [DE][LI]xCxE | | Motif Instance | EIRCDE | | Bait Uniprot Accession | Q13029 | | Bait Uniprot Identifier | PRDM2_HUMAN | | Bait Gene Name | PRDM2 | | Sequence Position | 309-314 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21800 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7538672 | | Comments | Rb-binding motif in human Retinoblastoma protein-interacting zinc finger protein (RIZ) that is necessary for binding to the human retinoblastoma suppressor protein (pRb) |
Record No : 144 |
| Instance ID | 11801 | | Regular Expression | [DE][LI]xCxE | | Motif Instance | EIRCEE | | Bait Uniprot Accession | Q63755 | | Bait Uniprot Identifier | PRDM2_RAT | | Bait Gene Name | Prdm2 | | Sequence Position | 304-309 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21801 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7538672 | | Comments | Rb-binding motif in rat Retinoblastoma protein-interacting zinc finger protein (Riz) that is necessary for binding to the human retinoblastoma suppressor protein (pRb) |
Record No : 145 |
| Instance ID | 11808 | | Regular Expression | [RK]x{0,1}[VIL][^P][FW] | | Motif Instance | RVTF | | Bait Uniprot Accession | Q12972 | | Bait Uniprot Identifier | PP1R8_HUMAN | | Bait Gene Name | PPP1R8 | | Sequence Position | 200-203 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide display library panning; Peptide binding assay | | Interaction ID | 21808 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9353294, 20044954 | | Comments | The RVXF motif in Nuclear inhibitor of protein phosphatase 1 (NIPP1) that mediates its binding to protein phosphatase PP1-alpha catalytic subunit (PPP1CA) |
Record No : 146 |
| Instance ID | 11811 | | Regular Expression | [RK]x{0,1}[VIL][^P][FW] | | Motif Instance | KKIQF | | Bait Uniprot Accession | Q9UD71 | | Bait Uniprot Identifier | PPR1B_HUMAN | | Bait Gene Name | PPP1R1B | | Sequence Position | 7-11 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; SPR | | Interaction ID | 21811 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10075680, 16428298 | | Comments | PP1-binding motif of DARPP-32 that mediates interaction with protein phosphatase PP1-alpha catalytic subunit (PPP1CA) and is critical for inhibition of PP1 |
Record No : 147 |
| Instance ID | 11812 | | Regular Expression | [RK]x{0,1}[VIL][^P][FW] | | Motif Instance | RKIQF | | Bait Uniprot Accession | Q13522 | | Bait Uniprot Identifier | PPR1A_HUMAN | | Bait Gene Name | PPP1R1A | | Sequence Position | 8-12 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis | | Interaction ID | 21812 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8611507 | | Comments | PP1-binding motif of human Protein phosphatase inhibitor 1 (IPP1) that binds to protein phosphatase PP1-alpha catalytic subunit (PPP1CA) |
Record No : 148 |
| Instance ID | 11813 | | Regular Expression | [RK]x{0,1}[VIL][^P][FW] | | Motif Instance | RKLHY | | Bait Uniprot Accession | P41236 | | Bait Uniprot Identifier | IPP2_HUMAN | | Bait Gene Name | PPP1R2 | | Sequence Position | 144-148 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; SPR | | Interaction ID | 21813 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16428298 | | Comments | PP1-binding motif of human Protein phosphatase inhibitor 2 (IPP2) that binds weakly to protein phosphatase PP1-alpha catalytic subunit (PPP1CA) |
Record No : 149 |
| Instance ID | 11814 | | Regular Expression | [RK]x{0,1}[VIL][^P][FW] | | Motif Instance | RKIHF | | Bait Uniprot Accession | Q96SB3 | | Bait Uniprot Identifier | NEB2_HUMAN | | Bait Gene Name | PPP1R9B | | Sequence Position | 445-449 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Ligand Overlay Assay; Co-IP | | Interaction ID | 21814 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10194355, 9275233 | | Comments | The pentapeptide motif of human Spinophilin (PPP1R9B) that participates in binding to human protein phosphatase PP1 for directing PP1 to postsynaptic densities and regulating its activity toward physiological substrates |
Record No : 150 |
| Instance ID | 11818 | | Regular Expression | RNYF | | Motif Instance | RNYF | | Bait Uniprot Accession | Q8WUF5 | | Bait Uniprot Identifier | IASPP_HUMAN | | Bait Gene Name | PPP1R13L | | Sequence Position | 812-815 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21818 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21998301 | | Comments | Noncanonical PP1 binding motif located within the SH3 domain of Inhibitor of ASPP protein (iASPP) that mediates interaction with human protein phosphatase PP1 |
Record No : 151 |
| Instance ID | 11822 | | Regular Expression | QLQKVHF | | Motif Instance | QLQKVHF | | Bait Uniprot Accession | P06746 | | Bait Uniprot Identifier | DPOLB_HUMAN | | Bait Gene Name | POLB | | Sequence Position | 217-223 | | Critical Residues | P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Competition binding assay | | Interaction ID | 21822 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12063248 | | Comments | The PCNA-binding motif in human DNA polymerase beta (POLB) that mediates its interaction with Proliferating cell nuclear antigen (PCNA) |
Record No : 152 |
| Instance ID | 11834 | | Regular Expression | ISxPx{2,4}FxHxxHVGxD | | Motif Instance | ISLPSDFEHTIHVGFD | | Bait Uniprot Accession | Q13153 | | Bait Uniprot Identifier | PAK1_HUMAN | | Bait Gene Name | PAK1 | | Sequence Position | 75-90 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; SPA; ITC | | Interaction ID | 21834 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9601050, 7493928 | | Comments | The Cdc42/Rac interactive binding (CRIB) motif in human PAK1 that forms a minimal consensus for binding to human CDC42 and is necessary but not sufficient for tight binding |
Record No : 153 |
| Instance ID | 11835 | | Regular Expression | ISxPx{2,4}FxHxxHVGxD | | Motif Instance | ISPPSDFEHTIHVGFD | | Bait Uniprot Accession | Q13177 | | Bait Uniprot Identifier | PAK2_HUMAN | | Bait Gene Name | PAK2 | | Sequence Position | 74-89 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | NMR; Fluorescence titration | | Interaction ID | 21835 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10320322 | | Comments | The Cdc42/Rac interactive binding (CRIB) motif in human PAK2 that forms a minimal consensus for binding to human CDC42 |
Record No : 154 |
| Instance ID | 11839 | | Regular Expression | ISxPx{2,4}FxHxxHVGxD | | Motif Instance | ISLPSDFEHTIHVGFD | | Bait Uniprot Accession | Q13153 | | Bait Uniprot Identifier | PAK1_HUMAN | | Bait Gene Name | PAK1 | | Sequence Position | 75-90 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; SPA | | Interaction ID | 21839 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9601050, 7493928 | | Comments | The Cdc42/Rac interactive binding (CRIB) motif in human PAK1 that forms a minimal consensus for binding to human RAC1 and is necessary but not sufficient for tight binding |
Record No : 155 |
| Instance ID | 11845 | | Regular Expression | PPGx[RK] | | Motif Instance | PPGAR | | Bait Uniprot Accession | Q92530 | | Bait Uniprot Identifier | PSMF1_HUMAN | | Bait Gene Name | PSMF1 | | Sequence Position | 248-252 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21845 | | Interacting Domain | GYF domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16000308 | | Comments | Proline-rich sequences (248-252) in human Proteasome inhibitor PI31 subunit that serves as a recognition motif for the GYF domain of the cellular adapter protein CD2BP2 |
Record No : 156 |
| Instance ID | 11846 | | Regular Expression | PPG[WFYML] | | Motif Instance | PPGY | | Bait Uniprot Accession | Q92530 | | Bait Uniprot Identifier | PSMF1_HUMAN | | Bait Gene Name | PSMF1 | | Sequence Position | 263-266 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21846 | | Interacting Domain | GYF domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16000308 | | Comments | Proline-rich sequences (263-266) in human Proteasome inhibitor PI31 subunit that serves as a recognition motif for the GYF domain of the cellular adapter protein CD2BP2 |
Record No : 157 |
| Instance ID | 11866 | | Regular Expression | EQWWLxLRP | | Motif Instance | EQWWLKLRP | | Bait Uniprot Accession | P08237 | | Bait Uniprot Identifier | PFKAM_HUMAN | | Bait Gene Name | PFKM | | Sequence Position | 739-747 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Phage Display; ELISA | | Interaction ID | 21866 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12649290 | | Comments | Consensus motif from Human muscle type Phosphofructokinase 1 (PFK-1) that mediates binding to the human Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4 (ATP6V0A4) |
Record No : 158 |
| Instance ID | 11867 | | Regular Expression | EQWWLxLRP | | Motif Instance | EQWWLKLRP | | Bait Uniprot Accession | Q01813 | | Bait Uniprot Identifier | PFKAP_HUMAN | | Bait Gene Name | PFKP | | Sequence Position | 748-756 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Phage Display; ELISA | | Interaction ID | 21867 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12649290 | | Comments | Consensus motif from Human platelet type Phosphofructokinase 1 (PFK-1) that mediates binding to the human Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4 (ATP6V0A4) |
Record No : 159 |
| Instance ID | 11868 | | Regular Expression | EQWWLxLRP | | Motif Instance | EQWWLSLRL | | Bait Uniprot Accession | P17858 | | Bait Uniprot Identifier | PFKAL_HUMAN | | Bait Gene Name | PFKL | | Sequence Position | 738-746 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Phage Display; ELISA | | Interaction ID | 21868 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12649290 | | Comments | Consensus motif from Human liver type Phosphofructokinase 1 (PFK-1) that mediates binding to the human Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4 (ATP6V0A4) |
Record No : 160 |
| Instance ID | 11869 | | Regular Expression | EQWWLxLRP | | Motif Instance | EQWWLKLRP | | Bait Uniprot Accession | P47857 | | Bait Uniprot Identifier | PFKAM_MOUSE | | Bait Gene Name | Pfkm | | Sequence Position | 739-747 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Phage Display; ELISA | | Interaction ID | 21869 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12649290 | | Comments | Consensus motif from Mouse muscle type Phosphofructokinase 1 (PFK-1) that mediates binding to the mouse Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4 (Atp6v0a4) |
Record No : 161 |
| Instance ID | 11870 | | Regular Expression | EQWWLxLRP | | Motif Instance | EQWWLKLRP | | Bait Uniprot Accession | Q9WUA3 | | Bait Uniprot Identifier | PFKAP_MOUSE | | Bait Gene Name | Pfkp | | Sequence Position | 747-755 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Phage Display; ELISA | | Interaction ID | 21870 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12649290 | | Comments | Consensus motif from Mouse platelet type Phosphofructokinase 1 (PFK-1) that mediates binding to the mouse Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4 (Atp6v0a4) |
Record No : 162 |
| Instance ID | 11871 | | Regular Expression | EQWWLxLRP | | Motif Instance | EQWWLNLRL | | Bait Uniprot Accession | P12382 | | Bait Uniprot Identifier | PFKAL_MOUSE | | Bait Gene Name | Pfkl | | Sequence Position | 738-746 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Phage Display; ELISA | | Interaction ID | 21871 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12649290 | | Comments | Consensus motif from Mouse liver type Phosphofructokinase 1 (PFK-1) that mediates binding to the mouse Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4 (Atp6v0a4) |
Record No : 163 |
| Instance ID | 11872 | | Regular Expression | EQWWLxLRP | | Motif Instance | EQWWLKLRP | | Bait Uniprot Accession | P00511 | | Bait Uniprot Identifier | PFKAM_RABIT | | Bait Gene Name | PFKM | | Sequence Position | 739-747 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Phage Display; ELISA | | Interaction ID | 21872 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12649290 | | Comments | Consensus motif from Rabbit muscle type Phosphofructokinase 1 (PFK-1) that mediates binding to rabbit ATP6V0A4 protein |
Record No : 164 |
| Instance ID | 11873 | | Regular Expression | EQWWLxLRP | | Motif Instance | EQWWLKLRP | | Bait Uniprot Accession | P47859 | | Bait Uniprot Identifier | PFKAP_RABIT | | Bait Gene Name | PFKP | | Sequence Position | 748-756 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Phage Display; ELISA | | Interaction ID | 21873 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12649290 | | Comments | Consensus motif from Rabbit platelet type Phosphofructokinase 1 (PFK-1) that mediates binding to rabbit ATP6V0A4 protein |
Record No : 165 |
| Instance ID | 11889 | | Regular Expression | YxxM | | Motif Instance | YMDM | | Bait Uniprot Accession | P05622 | | Bait Uniprot Identifier | PGFRB_MOUSE | | Bait Gene Name | Pdgfrb | | Sequence Position | 739-742 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21889 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif (739-742) in mouse Platelet-derived growth factor receptor beta that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 166 |
| Instance ID | 11890 | | Regular Expression | YxxM | | Motif Instance | YVPM | | Bait Uniprot Accession | P05622 | | Bait Uniprot Identifier | PGFRB_MOUSE | | Bait Gene Name | Pdgfrb | | Sequence Position | 750-753 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21890 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif (750-753) in mouse Platelet-derived growth factor receptor beta that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 167 |
| Instance ID | 11893 | | Regular Expression | SLKVWT | | Motif Instance | SLKVWT | | Bait Uniprot Accession | P16118 | | Bait Uniprot Identifier | F261_HUMAN | | Bait Gene Name | PFKFB1 | | Sequence Position | 298-303 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Phage Display; ELISA | | Interaction ID | 21893 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11522786 | | Comments | Consensus motif SLKVWT in the human bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) liver isozyme that mediates binding to low affinity glucose-phosphorylating enzyme Glucokinase |
Record No : 168 |
| Instance ID | 11894 | | Regular Expression | SLKVWT | | Motif Instance | SLKVWT | | Bait Uniprot Accession | P07953 | | Bait Uniprot Identifier | F261_RAT | | Bait Gene Name | Pfkfb1 | | Sequence Position | 298-303 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Phage Display; ELISA | | Interaction ID | 21894 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11522786 | | Comments | Consensus motif SLKVWT in the rat bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) liver isozyme that mediates binding to low affinity glucose-phosphorylating enzyme Glucokinase |
Record No : 169 |
| Instance ID | 11915 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | FPWMK | | Bait Uniprot Accession | P52947 | | Bait Uniprot Identifier | PDX1_RAT | | Bait Gene Name | Pdx1 | | Sequence Position | 119-123 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21915 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11158595 | | Comments | The highly conserved pentapeptide motif in rat homeobox factor Pdx1 that promotes heterodimer formation with the ubiquitous homeodomain protein PBX |
Record No : 170 |
| Instance ID | 11916 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | FPWMK | | Bait Uniprot Accession | P52945 | | Bait Uniprot Identifier | PDX1_HUMAN | | Bait Gene Name | PDX1 | | Sequence Position | 119-123 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21916 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8524276 | | Comments | The highly conserved pentapeptide motif in human pancreatic islet factor STF-1 that promotes heterodimer formation with the ubiquitous homeodomain protein PBX for cooperative binding to to a regulatory element in the somatostatin promoter |
Record No : 171 |
| Instance ID | 11977 | | Regular Expression | RxxL | | Motif Instance | RKAL | | Bait Uniprot Accession | O95997 | | Bait Uniprot Identifier | PTTG1_HUMAN | | Bait Gene Name | PTTG1 | | Sequence Position | 61-64 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21977 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11179223 | | Comments | Conserved D‐box motif in human Securin/PTTG protein that mediates its degradation by the APC/C coactivator CDC20 |
Record No : 172 |
| Instance ID | 11978 | | Regular Expression | [YF]xLxP | | Motif Instance | YNLKP | | Bait Uniprot Accession | Q96QC0 | | Bait Uniprot Identifier | PP1RA_HUMAN | | Bait Gene Name | PPP1R10 | | Sequence Position | 236-240 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21978 | | Interacting Domain | TRFH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19287395 | | Comments | The telomeric repeat binding factor (TRF) homology (TRFH) domain of human Telomeric repeat-binding factor 2 (TERF2/TRF2) recognizes and directly interacts with the [Y/F]XL motif in human Phosphatase 1 regulatory subunit 10 (PPP1R10/PNUTS) and regulates telomere maintenance |
Record No : 173 |
| Instance ID | 11988 | | Regular Expression | (Y)xNx | | Motif Instance | YDNY | | Bait Uniprot Accession | P09619 | | Bait Uniprot Identifier | PGFRB_HUMAN | | Bait Gene Name | PDGFRB | | Sequence Position | 775-778 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 21988 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8940081 | | Comments | The SH2 domain of Human Epidermal growth factor receptor GRB-7 can directly bind to the autophosphorylated PDGF beta-receptor (PDGFRB) through Tyr-775 |
Record No : 174 |
| Instance ID | 12000 | | Regular Expression | ETGE | | Motif Instance | ENGE | | Bait Uniprot Accession | P26350 | | Bait Uniprot Identifier | PTMA_MOUSE | | Bait Gene Name | Ptma | | Sequence Position | 43-46 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 22000 | | Interacting Domain | DGR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18391415 | | Comments | The Mouse nuclear oncoprotein Prothymosin alpha (Ptma) interacts directly with the beta propeller of mouse Keap1 through its ENGE peptide sequence |
Record No : 175 |
| Instance ID | 12014 | | Regular Expression | LxHxTxxRPKx{6,6}P | | Motif Instance | LAHPTRDRAKIQHSRRP | | Bait Uniprot Accession | Q53GL0 | | Bait Uniprot Identifier | PKHO1_HUMAN | | Bait Gene Name | PLEKHO1 | | Sequence Position | 150-166 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Sequence based prediction; Competition binding | | Interaction ID | 22014 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16707503 | | Comments | The motif present in human CKIP1/PLEKHO1 that is sufficient for binding to human F-actin-capping protein subunit alpha-1 (CapZ alpha-1) |
Record No : 176 |
| Instance ID | 12015 | | Regular Expression | LxHxTxxRPKx{6,6}P | | Motif Instance | LAHPTRDRAKIQHSRRP | | Bait Uniprot Accession | Q53GL0 | | Bait Uniprot Identifier | PKHO1_HUMAN | | Bait Gene Name | PLEKHO1 | | Sequence Position | 150-166 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Sequence based prediction; Competition binding | | Interaction ID | 22015 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16707503 | | Comments | The motif present in human CKIP1/PLEKHO1 that is sufficient for binding to human F-actin-capping protein subunit alpha-2 (CapZ alpha-2) |
Record No : 177 |
| Instance ID | 12016 | | Regular Expression | LxHxTxxRPKx{6,6}P | | Motif Instance | LAHPTRDRAKIQHSRRP | | Bait Uniprot Accession | Q53GL0 | | Bait Uniprot Identifier | PKHO1_HUMAN | | Bait Gene Name | PLEKHO1 | | Sequence Position | 150-166 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Sequence based prediction; Competition binding | | Interaction ID | 22016 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16707503 | | Comments | The motif present in human CKIP1/PLEKHO1 that is sufficient for binding to human F-actin-capping protein subunit beta (CapZ beta) |
Record No : 178 |
| Instance ID | 12017 | | Regular Expression | EKF | | Motif Instance | EKF | | Bait Uniprot Accession | Q38882 | | Bait Uniprot Identifier | PLDA1_ARATH | | Bait Gene Name | PLDALPHA1 | | Sequence Position | 563-565 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; ITC; Y2H; Co-IP; Pull down(GST tag) | | Interaction ID | 22017 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14594812, 16614222 | | Comments | Phospholipase D alpha 1 (PLDalpha1) interacts with the Galpha subunit of heterotrimeric GTP-binding protein (G protein) in Arabidopsis thaliana through its 563-EKF-565 motif to mediate ABA inhibition of stomatal opening |
Record No : 179 |
| Instance ID | 12026 | | Regular Expression | [RK]x{0,1}[VIL][^P][FWY] | | Motif Instance | RIWY | | Bait Uniprot Accession | Q9EMA9 | | Bait Uniprot Identifier | V_MEASE | | Bait Gene Name | P/V | | Sequence Position | 288-291 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22026 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25011105 | | Comments | PP1-binding motif in the measles virus V protein that binds to protein phosphatase PP1-alpha catalytic subunit (PPP1CA), preventing PP1-mediated dephosphorylation of MDA5 and thereby its activation |
Record No : 180 |
| Instance ID | 12027 | | Regular Expression | [RK]x{0,1}[VIL][^P][FWY] | | Motif Instance | RIWY | | Bait Uniprot Accession | Q9EMA9 | | Bait Uniprot Identifier | V_MEASE | | Bait Gene Name | P/V | | Sequence Position | 288-291 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22027 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25011105 | | Comments | PP1-binding motif in the measles virus V protein that binds to protein phosphatase PP1-gamma catalytic subunit (PPP1CC), preventing PP1-mediated dephosphorylation of MDA5 and thereby its activation |
Record No : 181 |
| Instance ID | 12072 | | Regular Expression | [IL]xx[IHL] | | Motif Instance | IDNL | | Bait Uniprot Accession | P07737 | | Bait Uniprot Identifier | PROF1_HUMAN | | Bait Gene Name | PFN1 | | Sequence Position | 8-11 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 22072 | | Interacting Domain | AF-2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 23576398 | | Comments | The signature motif in human Profilin-1 (PFN1) required for corepressor interaction with human Estrogen receptor (ER-alpha/ESR1) |
Record No : 182 |
| Instance ID | 12150 | | Regular Expression | PxxPx[KR] | | Motif Instance | PVTPPR | | Bait Uniprot Accession | P62140 | | Bait Uniprot Identifier | PP1B_HUMAN | | Bait Gene Name | PPP1CB | | Sequence Position | 314-319 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Affinity purification; SPR | | Interaction ID | 22150 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23088536 | | Comments | The putative SH3-binding PxxPxR motif in the C-terminus of human Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) that binds to the SH3 domain of human Apoptosis-stimulating of p53 protein 1 (ASPP1/PPP1R13B) |
Record No : 183 |
| Instance ID | 12151 | | Regular Expression | PxxPx[KR] | | Motif Instance | PVTPPR | | Bait Uniprot Accession | P62140 | | Bait Uniprot Identifier | PP1B_HUMAN | | Bait Gene Name | PPP1CB | | Sequence Position | 314-319 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Affinity purification; SPR; X-ray crystallography | | Interaction ID | 22151 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23088536 | | Comments | The putative SH3-binding PxxPxR motif in the C-terminus of human Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) that binds to the SH3 domain of human Apoptosis-stimulating of p53 protein 2 (ASPP2/TP53BP2) |
Record No : 184 |
| Instance ID | 12152 | | Regular Expression | PxxPx[KR] | | Motif Instance | PVTPPR | | Bait Uniprot Accession | P62140 | | Bait Uniprot Identifier | PP1B_HUMAN | | Bait Gene Name | PPP1CB | | Sequence Position | 314-319 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Affinity purification; SPR; X-ray crystallography | | Interaction ID | 22152 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23088536 | | Comments | The putative SH3-binding PxxPxR motif in the C-terminus of human Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) that binds to the SH3 domain of human Inhibitor of ASPP protein (IASPP/PPP1R13L) |
Record No : 185 |
| Instance ID | 12170 | | Regular Expression | N[ST]x[DT] | | Motif Instance | NTED | | Bait Uniprot Accession | Q9NR12 | | Bait Uniprot Identifier | PDLI7_HUMAN | | Bait Gene Name | PDLIM7 | | Sequence Position | 151-154 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Immuno slot-blot assay | | Interaction ID | 22170 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24078030 | | Comments | Unique motif in human PDZ and LIM domain protein 7 (PDLIM7)/ LIM mineralization protein (LMP) that interacts with human COP9 signalosome complex subunit 5 (COPS5)/ Jun activation domain-binding protein 1 (JAB1) |
Record No : 186 |
| Instance ID | 12197 | | Regular Expression | EEVD | | Motif Instance | EEVD | | Bait Uniprot Accession | P43686 | | Bait Uniprot Identifier | PRS6B_HUMAN | | Bait Gene Name | PSMC4 | | Sequence Position | 356-359 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Mutation analysis; Co-IP | | Interaction ID | 22197 | | Interacting Domain | Ankyrin repeat-containing domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17292836, 24338975 | | Comments | The EEVD sequence in the C-terminal domain of Proteasome 26S subunit ATPase 4 (PSMC4) that binds to the Ankyrin repeat-containing domain of mouse Gankyrin/ 26S proteasome non-ATPase regulatory subunit 10 (Psmd10) |
Record No : 187 |
| Instance ID | 12204 | | Regular Expression | LxxLLxxxLxxF | | Motif Instance | LEELLESALDDF | | Bait Uniprot Accession | P40855 | | Bait Uniprot Identifier | PEX19_HUMAN | | Bait Gene Name | PEX19 | | Sequence Position | 18-29 | | Critical Residues | P12 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; X-ray crystallography; ITC | | Interaction ID | 22204 | | Interacting Domain | Cytosolic domain of PEX3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20554521 | | Comments | LxxLLxxxLxxF motif located in N-terminus of human Peroxisomal biogenesis factor 19 (PEX19) that is responsible for binding to the cytosolic domain of the integral membrane protein PEX3 |
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