|
Total : 119 Records
Record No : 1 |
| Instance ID | 10028 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RRCRSLP | | Bait Uniprot Accession | Q63572 | | Bait Uniprot Identifier | TESK1_RAT | | Bait Gene Name | Tesk1 | | Sequence Position | 435-441 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20028 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11555644 | | Comments | 14-3-3 beta interacts with Tesk1 through the C-terminal region of Tesk1 and in a manner dependent on the phosphorylation of Ser-439 within an RXXSXP motif |
Record No : 2 |
| Instance ID | 10101 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | DKPDMAEIEKFDKSKLKKT | | Bait Uniprot Accession | P20065 | | Bait Uniprot Identifier | TYB4_MOUSE | | Bait Gene Name | Tmsb4x | | Sequence Position | 9-27 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Cross linking studies | | Interaction ID | 20101 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1464307 | | Comments | The WH2 motif in mouse Thymosin beta-4 that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 3 |
| Instance ID | 10112 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | DKPDMAEIEKFDKSKLKKT | | Bait Uniprot Accession | A2VCK8 | | Bait Uniprot Identifier | A2VCK8_HUMAN | | Bait Gene Name | TMSB4X | | Sequence Position | 3-21 | | Critical Residues | P17; P18 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | ITC; structure based prediction; Sequence based prediction; X-ray crystallography; Mutation analysis; Cross linking studies; circular dichroism | | Interaction ID | 20112 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16275905, 8617195 | | Comments | The WH2 motif in human Thymosin beta 4 that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 4 |
| Instance ID | 10130 | | Regular Expression | FxxF$ | | Motif Instance | FRDF | | Bait Uniprot Accession | P06244 | | Bait Uniprot Identifier | KAPA_YEAST | | Bait Gene Name | TPK1 | | Sequence Position | 394-397 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20130 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21531713 | | Comments | "The C-terminal hydrophobic motif in yeast Tpk1, the catalytic subunit of protein kinase A, which acts as a ""docking site"" for its phosphorylation by PKH1, the yeast ortholog of mammalian PDK1" |
Record No : 5 |
| Instance ID | 10220 | | Regular Expression | ((SP)|([ED]x{0,1}))[IV]W[IVL]xR | | Motif Instance | EVIWVRR | | Bait Uniprot Accession | Q13009 | | Bait Uniprot Identifier | TIAM1_HUMAN | | Bait Gene Name | TIAM1 | | Sequence Position | 1572-1578 | | Critical Residues | P3; P4; P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20220 | | Interacting Domain | CaMK domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21763699 | | Comments | The CASK-CaMK-binding motif in human TIAM1 that mediates specific binding to the CaMK domain of the CASK protein |
Record No : 6 |
| Instance ID | 10227 | | Regular Expression | [ED]x{0,2}[ED]x{0,2}[EDQ]x{0,1}[YF]$ | | Motif Instance | EGEEEGEEY | | Bait Uniprot Accession | Q71U36 | | Bait Uniprot Identifier | TBA1A_HUMAN | | Bait Gene Name | TUBA1A | | Sequence Position | 443-451 | | Critical Residues | P4; P5; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; NMR; Mutation analysis; SPR | | Interaction ID | 20227 | | Interacting Domain | CAP-Gly domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16954346, 17563362 | | Comments | The C-Terminal acidic tail of Tubulin alpha-1A chain that is responsible for CLIP-170 binding, thus providing a structural basis for the proposed CLIP-170 copolymerization with tubulin on the microtubule plus end |
Record No : 7 |
| Instance ID | 10259 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PPDLS | | Bait Uniprot Accession | P17789 | | Bait Uniprot Identifier | TTKB_DROME | | Bait Gene Name | ttk | | Sequence Position | 593-597 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning | | Interaction ID | 20259 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10978285 | | Comments | The PxDLS CtBP ligand motif in Drosophila repressor protein Tramtrack p69 (Ttk69) that is critical for mediating interaction with the Drosophila homolog of C-terminal-binding protein (dCtBP) and essential for Ttk69 function |
Record No : 8 |
| Instance ID | 10268 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PLDLS | | Bait Uniprot Accession | Q15583 | | Bait Uniprot Identifier | TGIF1_HUMAN | | Bait Gene Name | TGIF1 | | Sequence Position | 153-157 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning | | Interaction ID | 20268 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Holoprosencephaly | | Inhibitor(s) | Unknown | | Reference(s) | 10995736 | | Comments | The homeodomain protein TGIF1 interacts with the transcriptional corepressor CtBP via the PxDLS motif |
Record No : 9 |
| Instance ID | 10272 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PLDLA | | Bait Uniprot Accession | Q9UHF7 | | Bait Uniprot Identifier | TRPS1_HUMAN | | Bait Gene Name | TRPS1 | | Sequence Position | 1163-1167 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20272 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12444977 | | Comments | Ikaros-related protein TRPS1 contains a PXDLS CtBP contact motif within its repression domain for binding to murine CtBP2 |
Record No : 10 |
| Instance ID | 10273 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PLSLT | | Bait Uniprot Accession | P70062 | | Bait Uniprot Identifier | T7L1A_XENLA | | Bait Gene Name | tcf7l1-a | | Sequence Position | 469-473 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20273 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10375506 | | Comments | Xenopus homolog of C-terminal binding protein 1 (XCtBP1) interacts with Xenopus HMG box transcription factor TCF-3-A through the carboxy-terminal PxDLS motif (469-473) |
Record No : 11 |
| Instance ID | 10274 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PLSLV | | Bait Uniprot Accession | P70062 | | Bait Uniprot Identifier | T7L1A_XENLA | | Bait Gene Name | tcf7l1-a | | Sequence Position | 545-549 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20274 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10375506 | | Comments | Xenopus homolog of C-terminal binding protein 1 (XCtBP1) interacts with Xenopus HMG box transcription factor TCF-3-A through the carboxy-terminal PxDLS motif (545-549) |
Record No : 12 |
| Instance ID | 10295 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | KKLMF | | Bait Uniprot Accession | P04637 | | Bait Uniprot Identifier | P53_HUMAN | | Bait Gene Name | TP53 | | Sequence Position | 381-385 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Mutation analysis; ITC; X-ray crystallography; Overlapping binding peptide | | Interaction ID | 20295 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10884347, 12501191 | | Comments | The C-terminal regulatory domain of human cellular tumor antigen p53 contains a functional docking site for cyclin A that is shared between the tumour suppressor proteins pRb and p53 |
Record No : 13 |
| Instance ID | 10311 | | Regular Expression | xAxGPPx{2,3}Yx | | Motif Instance | PAVGPPSLAYL | | Bait Uniprot Accession | Q7M6U3 | | Bait Uniprot Identifier | TEX14_MOUSE | | Bait Gene Name | Tex14 | | Sequence Position | 788-798 | | Critical Residues | P4; P5; P6; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | gal4 vp16 complementation; Co-IP; Y2H; Competition binding; Mutation analysis | | Interaction ID | 20311 | | Interacting Domain | EABR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20176808 | | Comments | Cep55 EABR-binding motif in mouse Tex14 that mediates binding to the EABR domain of Cep55 to block cell abscission |
Record No : 14 |
| Instance ID | 10312 | | Regular Expression | xAxGPPx{2,3}Yx | | Motif Instance | LAVGPPSLNYI | | Bait Uniprot Accession | Q8IWB6 | | Bait Uniprot Identifier | TEX14_HUMAN | | Bait Gene Name | TEX14 | | Sequence Position | 792-802 | | Critical Residues | P4; P5; P6; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | gal4 vp16 complementation; Y2H; Competition binding; Mutation analysis | | Interaction ID | 20312 | | Interacting Domain | EABR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20176808 | | Comments | Cep55 EABR-binding motif in human TEX14 that mediates binding to the EABR domain of CEP55 to block cell abscission |
Record No : 15 |
| Instance ID | 10315 | | Regular Expression | xAxGPPx{2,3}Yx | | Motif Instance | TATGPPNTSYM | | Bait Uniprot Accession | Q61187 | | Bait Uniprot Identifier | TS101_MOUSE | | Bait Gene Name | Tsg101 | | Sequence Position | 155-165 | | Critical Residues | P4; P5; P6; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | gal4 vp16 complementation; Competition binding | | Interaction ID | 20315 | | Interacting Domain | EABR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20176808 | | Comments | Cep55 EABR-binding motif in mouse Tumor susceptibility gene 101 protein that mediates binding to the EABR domain of Cep55 |
Record No : 16 |
| Instance ID | 10316 | | Regular Expression | xAxGPPx{2,3}Yx | | Motif Instance | QATGPPNTSYM | | Bait Uniprot Accession | Q99816 | | Bait Uniprot Identifier | TS101_HUMAN | | Bait Gene Name | TSG101 | | Sequence Position | 154-164 | | Critical Residues | P4; P5; P6; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Colocalization; Alanine scanning; Mutation analysis; Cosedimentation; ITC; Competition binding; gal4 vp16 complementation | | Interaction ID | 20316 | | Interacting Domain | EABR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17853893, 18948538, 20176808 | | Comments | Cep55 EABR-binding motif in human Tumor susceptibility gene 101 protein that mediates binding to the EABR domain of CEP55 |
Record No : 17 |
| Instance ID | 10409 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YGPTFLL | | Bait Uniprot Accession | P39935 | | Bait Uniprot Identifier | IF4F1_YEAST | | Bait Gene Name | TIF4631 | | Sequence Position | 452-458 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag) | | Interaction ID | 20409 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9118949 | | Comments | YxxxxL motif in yeast Eukaryotic initiation factor 4F subunit p150 (eIF4G1) that mediate binding to the dorsal surface of eIF4E, a key regulator of eukaryotic cap-dependent translation, and play a role in translation initiation, via interactions with eIF4G |
Record No : 18 |
| Instance ID | 10410 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YGPTFLL | | Bait Uniprot Accession | P39936 | | Bait Uniprot Identifier | IF4F2_YEAST | | Bait Gene Name | TIF4632 | | Sequence Position | 423-429 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag) | | Interaction ID | 20410 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9118949 | | Comments | YxxxxL motif in yeast Eukaryotic initiation factor 4F subunit p130 (eIF4G2) that mediate binding to the dorsal surface of eIF4E, a key regulator of eukaryotic cap-dependent translation, and play a role in translation initiation, via interactions with eIF4G |
Record No : 19 |
| Instance ID | 10458 | | Regular Expression | [DE]HxY | | Motif Instance | DHSY | | Bait Uniprot Accession | Q9JJD0 | | Bait Uniprot Identifier | THA11_MOUSE | | Bait Gene Name | Thap11 | | Sequence Position | 234-237 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20458 | | Interacting Domain | Galactose oxidase, central domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20581084 | | Comments | The zinc finger transcriptional regulator, Ronin (Thap11), can interact with the cell growth factor Hcf-1, via a consensus HCF-binding motif (HBM), and together Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of mouse embryonic stem cells |
Record No : 20 |
| Instance ID | 10459 | | Regular Expression | [DE]HxY | | Motif Instance | DHNY | | Bait Uniprot Accession | Q9NVV9 | | Bait Uniprot Identifier | THAP1_HUMAN | | Bait Gene Name | THAP1 | | Sequence Position | 134-137 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H | | Interaction ID | 20459 | | Interacting Domain | Galactose oxidase, central domain | | Disease Association(s) | Neurological disease | | Inhibitor(s) | Unknown | | Reference(s) | 20200153 | | Comments | The Human THAP-zinc finger protein THAP1 associates with coactivator HCF-1 through its HCF-1-binding motif (HBM) |
Record No : 21 |
| Instance ID | 10462 | | Regular Expression | [DE]HxY | | Motif Instance | DHSY | | Bait Uniprot Accession | Q8WTV1 | | Bait Uniprot Identifier | THAP3_HUMAN | | Bait Gene Name | THAP3 | | Sequence Position | 177-180 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP; AP-MS; Pull down(GST tag) | | Interaction ID | 20462 | | Interacting Domain | Galactose oxidase, central domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20200153 | | Comments | The Human THAP-zinc finger protein THAP3 associates with coactivator HCF-1 through its HCF-1-binding motif (HBM) |
Record No : 22 |
| Instance ID | 10470 | | Regular Expression | P[MVLIRWY]V[MVLIAS][LM] | | Motif Instance | PMVAL | | Bait Uniprot Accession | O00268 | | Bait Uniprot Identifier | TAF4_HUMAN | | Bait Gene Name | TAF4 | | Sequence Position | 764-768 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20470 | | Interacting Domain | Chromo shadow domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11959914 | | Comments | Human Transcription initiation factor TFIID subunit 4/TAF(II)130 possesses a pentapeptide HP1-binding motif that interacts with an interface formed by dimerization of two chromoshadow domains of HP1 gamma |
Record No : 23 |
| Instance ID | 10472 | | Regular Expression | P[MVLIRWY]V[MVLIAS][LM] | | Motif Instance | PRVSL | | Bait Uniprot Accession | Q13263 | | Bait Uniprot Identifier | TIF1B_HUMAN | | Bait Gene Name | TRIM28 | | Sequence Position | 486-490 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR; GFP tag; Competition binding; Co-IP; Western blot; Mutation analysis | | Interaction ID | 20472 | | Interacting Domain | Chromo shadow domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10938122, 16637071, 10938122 | | Comments | Human Nuclear corepressor KAP-1 (E3 SUMO-protein ligase TRIM28) interacts with heterochromatin protein 1alpha (HP1 alpha/CBX5) using a HP1-binding motif that interacts with an interface formed by dimerization of two chromoshadow domains in HP1 |
Record No : 24 |
| Instance ID | 10473 | | Regular Expression | P[MVLIRWY]V[MVLIAS][LM] | | Motif Instance | PRVSL | | Bait Uniprot Accession | Q62318 | | Bait Uniprot Identifier | TIF1B_MOUSE | | Bait Gene Name | Trim28 | | Sequence Position | 486-490 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Fluorescence technology; Co-IP; Alanine scanning | | Interaction ID | 20473 | | Interacting Domain | Chromo shadow domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12154074 | | Comments | The PxVxL HP1-binding motif found in the murine transcriptional intermediary factor 1 (TIF1) family protein TIF1beta that interacts with an interface formed by dimerization of two chromoshadow domains of HP1 alpha |
Record No : 25 |
| Instance ID | 10578 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | RLQKLLK | | Bait Uniprot Accession | Q16881 | | Bait Uniprot Identifier | TRXR1_HUMAN | | Bait Gene Name | TXNRD1 | | Sequence Position | 46-52 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Pull down(GST tag); Colocalization(Confocal microscopy); Competition binding | | Interaction ID | 20578 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15199063 | | Comments | The NR box motif of human Thioredoxin reductase TR1 (TXNRD1/GRIM12) that is necessary for binding the human Estrogen receptor (ESR1) |
Record No : 26 |
| Instance ID | 10579 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | RLQKLLK | | Bait Uniprot Accession | Q16881 | | Bait Uniprot Identifier | TRXR1_HUMAN | | Bait Gene Name | TXNRD1 | | Sequence Position | 46-52 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Pull down(GST tag); Colocalization(Confocal microscopy); Competition binding | | Interaction ID | 20579 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15199063 | | Comments | The NR box motif of human Thioredoxin reductase TR1 (TXNRD1/GRIM12) that is necessary for binding the human Estrogen receptor beta (ESR2) |
Record No : 27 |
| Instance ID | 10601 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | LQLNPAAREFKPD | | Bait Uniprot Accession | P53804 | | Bait Uniprot Identifier | TTC3_HUMAN | | Bait Gene Name | TTC3 | | Sequence Position | 1205-1217 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 20601 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16554297 | | Comments | The MLLE/PABC domain of human Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) binds to the N-terminal PAM2 motif of human E3 ubiquitin-protein ligase TTC3 |
Record No : 28 |
| Instance ID | 10602 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | LQLNPAAREFKPD | | Bait Uniprot Accession | P53804 | | Bait Uniprot Identifier | TTC3_HUMAN | | Bait Gene Name | TTC3 | | Sequence Position | 1205-1217 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC | | Interaction ID | 20602 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16554297 | | Comments | The MLLE/PABC domain of rat E3 ubiquitin-protein ligase Ubr5 binds to the N-terminal PAM2 motif of human E3 ubiquitin-protein ligase TTC3 |
Record No : 29 |
| Instance ID | 10605 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | SALSPNAKEFIFP | | Bait Uniprot Accession | P50616 | | Bait Uniprot Identifier | TOB1_HUMAN | | Bait Gene Name | TOB1 | | Sequence Position | 265-277 | | Critical Residues | P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis; Co-IP; ITC; NMR | | Interaction ID | 20605 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17785442, 18056425, 20595394 | | Comments | The PAM2 motif (265-277) in human TOB1, an antiproliferative transcription factor, that mediates binding to the MLLE domain of Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) |
Record No : 30 |
| Instance ID | 10606 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | SQLSPNAKEFVYN | | Bait Uniprot Accession | Q14106 | | Bait Uniprot Identifier | TOB2_HUMAN | | Bait Gene Name | TOB2 | | Sequence Position | 251-263 | | Critical Residues | P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis; SPR; ITC | | Interaction ID | 20606 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17785442, 16554297 | | Comments | The PAM2 motif (251-263) in human TOB2 that mediates binding to the MLLE domain of Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) |
Record No : 31 |
| Instance ID | 10607 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | SSFNPDAQVFVPI | | Bait Uniprot Accession | Q14106 | | Bait Uniprot Identifier | TOB2_HUMAN | | Bait Gene Name | TOB2 | | Sequence Position | 131-143 | | Critical Residues | P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis; SPR; ITC | | Interaction ID | 20607 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17785442, 16554297 | | Comments | The PAM2 motif (131-143) in human TOB2 that mediates binding to the MLLE domain of Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) |
Record No : 32 |
| Instance ID | 10610 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | NSFNPEAQVFMPI | | Bait Uniprot Accession | P50616 | | Bait Uniprot Identifier | TOB1_HUMAN | | Bait Gene Name | TOB1 | | Sequence Position | 130-142 | | Critical Residues | P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis; ITC; NMR | | Interaction ID | 20610 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17785442, 20595394 | | Comments | The PAM2 motif (130-142) in human TOB1, an antiproliferative transcription factor, that mediates binding to the MLLE domain of Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) |
Record No : 33 |
| Instance ID | 10663 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | FRETEV | | Bait Uniprot Accession | P03409 | | Bait Uniprot Identifier | TAX_HTL1A | | Bait Gene Name | tax | | Sequence Position | 348-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Y2H; Western blot; Co-IP; Mutation analysis | | Interaction ID | 20663 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482110 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) that binds to the PDZ domain of rat Dlg4 or Psd95 |
Record No : 34 |
| Instance ID | 10717 | | Regular Expression | xP[TS]APx | | Motif Instance | VPTAPA | | Bait Uniprot Accession | O75674 | | Bait Uniprot Identifier | TM1L1_HUMAN | | Bait Gene Name | TOM1L1 | | Sequence Position | 178-183 | | Critical Residues | P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down | | Interaction ID | 20717 | | Interacting Domain | UEV domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18367816 | | Comments | The UEV Domain binding P[TS]AP motif (178-183) in human TOM1L1 that mediates binding to the UEV domain of human Tumor susceptibility gene 101 protein (TSG101) |
Record No : 35 |
| Instance ID | 10725 | | Regular Expression | xP[TS]APx | | Motif Instance | IPTAPL | | Bait Uniprot Accession | Q99816 | | Bait Uniprot Identifier | TS101_HUMAN | | Bait Gene Name | TSG101 | | Sequence Position | 319-324 | | Critical Residues | P2; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20725 | | Interacting Domain | UEV domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12802020 | | Comments | The UEV Domain binding P[TS]AP motif in Human ESCRT-I complex subunit TSG101 that can bind to its own UEV domain through intermolecular or intramolecular interaction |
Record No : 36 |
| Instance ID | 10727 | | Regular Expression | xP[TS]APx | | Motif Instance | EPSAPS | | Bait Uniprot Accession | O75674 | | Bait Uniprot Identifier | TM1L1_HUMAN | | Bait Gene Name | TOM1L1 | | Sequence Position | 309-314 | | Critical Residues | P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Alanine scanning | | Interaction ID | 20727 | | Interacting Domain | UEV domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18367816 | | Comments | The UEV Domain binding P[TS]AP motif (309-314) in human TOM1L1 that mediates binding to the UEV domain of human Tumor susceptibility gene 101 protein (TSG101) |
Record No : 37 |
| Instance ID | 10791 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LFCFE | | Bait Uniprot Accession | Q12931 | | Bait Uniprot Identifier | TRAP1_HUMAN | | Bait Gene Name | TRAP1 | | Sequence Position | 525-529 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20791 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8756626 | | Comments | The Rb-binding LxCxE motif in the Human Heat shock protein HSP75/TRAP1 that mediates binding to the human retinoblastoma protein (RB) during mitosis and after heat shock, which suggests that HSP75 may act as a chaperone molecule to refold denatured RB into its native conformation |
Record No : 38 |
| Instance ID | 10897 | | Regular Expression | xxx[PV]xxP | | Motif Instance | YGPVLSP | | Bait Uniprot Accession | O15350 | | Bait Uniprot Identifier | P73_HUMAN | | Bait Gene Name | TP73 | | Sequence Position | 407-413 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20897 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10391251 | | Comments | Human Proto-oncogene c-Abl (ABL1) binds to human Tumor protein p73 (TP73) via its SH3 domain and thereby stimulates p73-mediated transactivation and apoptosis in response to DNA damage |
Record No : 39 |
| Instance ID | 10930 | | Regular Expression | [FA]x[LA][LV][LVI]xx[AM] | | Motif Instance | FQLLVDVA | | Bait Uniprot Accession | Q15583 | | Bait Uniprot Identifier | TGIF1_HUMAN | | Bait Gene Name | TGIF1 | | Sequence Position | 379-386 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 20930 | | Interacting Domain | PAH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11571228 | | Comments | The Human homeodomain protein TG-interacting factor (TGIF) interacts directly with the PAH2 domain of mouse Transcriptional corepressor Sin3a and thereby recruits mSin3 to a TGFbeta-activated Smad complex |
Record No : 40 |
| Instance ID | 10996 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | PRGCADGR | | Bait Uniprot Accession | P54274 | | Bait Uniprot Identifier | TERF1_HUMAN | | Bait Gene Name | TERF1 | | Sequence Position | 12-19 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag); Alanine scanning; X-ray crystallography | | Interaction ID | 20996 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12080061, 22153077 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human Telomeric repeat-binding factor 1 (TERF1) |
Record No : 41 |
| Instance ID | 11007 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | WRPQPDGE | | Bait Uniprot Accession | Q9C0C2 | | Bait Uniprot Identifier | TB182_HUMAN | | Bait Gene Name | TNKS1BP1 | | Sequence Position | 1507-1514 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down(GST tag) | | Interaction ID | 21007 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12080061 | | Comments | The ANK subdomain V in human poly(ADP-ribose)polymerase Tankyrase-1 (TNKS) interacts with the Tankyrase-binding motif in human TAB182 (182-kDa tankyrase-binding protein) |
Record No : 42 |
| Instance ID | 11008 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | WRPQPDGE | | Bait Uniprot Accession | Q9C0C2 | | Bait Uniprot Identifier | TB182_HUMAN | | Bait Gene Name | TNKS1BP1 | | Sequence Position | 1507-1514 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down(GST tag) | | Interaction ID | 21008 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12080061 | | Comments | The ANK subdomain V in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human TAB182 (182-kDa tankyrase-binding protein) |
Record No : 43 |
| Instance ID | 11014 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | PEQE | | Bait Uniprot Accession | P28908 | | Bait Uniprot Identifier | TNR8_HUMAN | | Bait Gene Name | TNFRSF8 | | Sequence Position | 561-564 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP; Pull down(GST tag) | | Interaction ID | 21014 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8662842 | | Comments | Human Lymphocyte activation antigen CD30, a member of the tumor necrosis factor (TNF) receptor family of proteins, initiate intracellular signaling by recruiting the C-domain of human TNF receptor-associated factor 1 (TRAF1) through a consensus motif in its cytoplasmic tail |
Record No : 44 |
| Instance ID | 11015 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | PEQE | | Bait Uniprot Accession | P28908 | | Bait Uniprot Identifier | TNR8_HUMAN | | Bait Gene Name | TNFRSF8 | | Sequence Position | 561-564 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP; Pull down(GST tag) | | Interaction ID | 21015 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8662842 | | Comments | Human Lymphocyte activation antigen CD30, a member of the tumor necrosis factor (TNF) receptor family of proteins, initiate intracellular signaling by recruiting the C-domain of human TNF receptor-associated factor 2 (TRAF2) through a consensus motif in its cytoplasmic tail |
Record No : 45 |
| Instance ID | 11016 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | PEQE | | Bait Uniprot Accession | P28908 | | Bait Uniprot Identifier | TNR8_HUMAN | | Bait Gene Name | TNFRSF8 | | Sequence Position | 561-564 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP; Pull down(GST tag) | | Interaction ID | 21016 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8662842 | | Comments | Human Lymphocyte activation antigen CD30, a member of the tumor necrosis factor (TNF) receptor family of proteins, initiate intracellular signaling by recruiting the C-domain of human TNF receptor-associated factor 3 (TRAF3)/CRAF1 through a consensus motif in its cytoplasmic tail |
Record No : 46 |
| Instance ID | 11018 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | SVEE | | Bait Uniprot Accession | P28908 | | Bait Uniprot Identifier | TNR8_HUMAN | | Bait Gene Name | TNFRSF8 | | Sequence Position | 578-581 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 21018 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10518213, 8662842 | | Comments | Human Lymphocyte activation antigen CD30, a TNF receptor superfamily member, associates with the human TNF receptor-associated factor 2 (TRAF2) through a TRAF2 binding site in its cytoplasmic domain |
Record No : 47 |
| Instance ID | 11019 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | SKEE | | Bait Uniprot Accession | P20333 | | Bait Uniprot Identifier | TNR1B_HUMAN | | Bait Gene Name | TNFRSF1B | | Sequence Position | 424-427 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21019 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10206649 | | Comments | The TRAF domain of human TNF receptor-associated factor 2 (TRAF2) binds to the TRAF2-binding consensus motif in human Tumor necrosis factor receptor 2 (TNFR2/TNFRSF1B) |
Record No : 48 |
| Instance ID | 11021 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | PIQE | | Bait Uniprot Accession | P43489 | | Bait Uniprot Identifier | TNR4_HUMAN | | Bait Gene Name | TNFRSF4 | | Sequence Position | 262-265 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21021 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10518213 | | Comments | The TRAF domain of human TNF receptor-associated factor 2 (TRAF2) binds to the TRAF2-binding consensus motif in human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4)/ OX40L receptor |
Record No : 49 |
| Instance ID | 11027 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | NTPGEDHEP | | Bait Uniprot Accession | O35305 | | Bait Uniprot Identifier | TNR11_MOUSE | | Bait Gene Name | Tnfrsf11a | | Sequence Position | 445-453 | | Critical Residues | P3; P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21027 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12140561 | | Comments | The C-terminal TRAF domain of human TNF receptor-associated factor 6 (TRAF6) interacts with the TRAF6 binding site (445-453) of mouse Osteoclast differentiation factor receptor (ODFR)/Rank/TRANCE-R |
Record No : 50 |
| Instance ID | 11029 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | KIPTEDEYT | | Bait Uniprot Accession | O35305 | | Bait Uniprot Identifier | TNR11_MOUSE | | Bait Gene Name | Tnfrsf11a | | Sequence Position | 338-346 | | Critical Residues | P3; P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21029 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12140561 | | Comments | The C-terminal TRAF domain of human TNF receptor-associated factor 6 (TRAF6) interacts with the TRAF6 binding site (338-346) of mouse Osteoclast differentiation factor receptor (ODFR)/Rank/TRANCE-R |
Record No : 51 |
| Instance ID | 11030 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | QEPLEVGEN | | Bait Uniprot Accession | O35305 | | Bait Uniprot Identifier | TNR11_MOUSE | | Bait Gene Name | Tnfrsf11a | | Sequence Position | 371-379 | | Critical Residues | P3; P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21030 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12140561 | | Comments | The C-terminal TRAF domain of human TNF receptor-associated factor 6 (TRAF6) interacts with the TRAF6 binding site (371-379) of mouse Osteoclast differentiation factor receptor (ODFR)/Rank/TRANCE-R |
Record No : 52 |
| Instance ID | 11033 | | Regular Expression | [FY]xLxP | | Motif Instance | FNLAP | | Bait Uniprot Accession | Q9BSI4 | | Bait Uniprot Identifier | TINF2_HUMAN | | Bait Gene Name | TINF2 | | Sequence Position | 258-262 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; ITC; Co-IP; X-ray crystallography | | Interaction ID | 21033 | | Interacting Domain | TRFH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18202258 | | Comments | The telomeric repeat binding factor (TRF) homology (TRFH) domain of human Telomeric repeat-binding factor 1 (TERF1/PIN2/TRF1) recognizes and directly interacts with the [Y/F]XL motif in human TERF1-interacting nuclear factor 2 (TINF2/TIN2) and regulates telomere maintenance |
Record No : 53 |
| Instance ID | 11040 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | PGGSR | | Bait Uniprot Accession | P04637 | | Bait Uniprot Identifier | P53_HUMAN | | Bait Gene Name | TP53 | | Sequence Position | 359-363 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Mutation analysis; Classical fluorescence spectroscopy; ITC | | Interaction ID | 21040 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16474402, 16402859 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (359-363) in human Cellular tumor antigen P53 |
Record No : 54 |
| Instance ID | 11041 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | AHSSH | | Bait Uniprot Accession | P04637 | | Bait Uniprot Identifier | P53_HUMAN | | Bait Gene Name | TP53 | | Sequence Position | 364-368 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Mutation analysis; Classical fluorescence spectroscopy | | Interaction ID | 21041 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16474402 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (364-368) in human Cellular tumor antigen P53 |
Record No : 55 |
| Instance ID | 11063 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | O15350 | | Bait Uniprot Identifier | P73_HUMAN | | Bait Gene Name | TP73 | | Sequence Position | 484-487 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Ubiquitinase assay; Co-IP; Pull down(GST tag); Mutation analysis | | Interaction ID | 21063 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15678106 | | Comments | The human WW domain-containing E3 ubiquitin-protein ligase ITCH selectively binds and ubiquitinates the human Tumor protein TP73 via the PPXY motif of TP73, which results in the rapid proteasome-dependent degradation of TP73 |
Record No : 56 |
| Instance ID | 11064 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | O15350 | | Bait Uniprot Identifier | P73_HUMAN | | Bait Gene Name | TP73 | | Sequence Position | 484-487 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down(GST tag); Pull down(His tag); Mutation analysis | | Interaction ID | 21064 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11278685 | | Comments | The PPXY motif of human Tumor protein TP73 provides a binding site for human transcription coactivator Yes-associated protein (YAP1/YAP65) |
Record No : 57 |
| Instance ID | 11075 | | Regular Expression | xxx([ST])Px | | Motif Instance | NVLSPL | | Bait Uniprot Accession | P04637 | | Bait Uniprot Identifier | P53_HUMAN | | Bait Gene Name | TP53 | | Sequence Position | 30-35 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 21075 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12388558 | | Comments | DNA damage enhances the interaction between human Peptidyl-prolyl cis-trans isomerase PIN1 and Cellular tumor antigen TP53 mediated by the WW domain in PIN1 and Ser(33)-Pro motif in TP53, whereby PIN1 regulates the stability of TP53 and its transcriptional activity towards the p21 promoter |
Record No : 58 |
| Instance ID | 11077 | | Regular Expression | xxx([ST])Px | | Motif Instance | PVLSPM | | Bait Uniprot Accession | O15350 | | Bait Uniprot Identifier | P73_HUMAN | | Bait Gene Name | TP73 | | Sequence Position | 409-414 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Mutation analysis; Pull down; Co-IP | | Interaction ID | 21077 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15175157 | | Comments | The phosphorylation-dependent interaction between the WW domain of human Peptidyl-prolyl cis-trans isomerase PIN1 and Ser(412)-Pro motif in human Tumor protein TP73 is essential for activation of the apoptotic response by endogenous P73 |
Record No : 59 |
| Instance ID | 11078 | | Regular Expression | xxx([ST])Px | | Motif Instance | SAATPN | | Bait Uniprot Accession | O15350 | | Bait Uniprot Identifier | P73_HUMAN | | Bait Gene Name | TP73 | | Sequence Position | 439-444 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Mutation analysis; Pull down; Co-IP | | Interaction ID | 21078 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15175157 | | Comments | The phosphorylation-dependent interaction between the WW domain of human Peptidyl-prolyl cis-trans isomerase PIN1 and Thr(442)-Pro motif in human Tumor protein TP73 is essential for activation of the apoptotic response by endogenous P73 |
Record No : 60 |
| Instance ID | 11079 | | Regular Expression | xxx([ST])Px | | Motif Instance | SHCTPP | | Bait Uniprot Accession | O15350 | | Bait Uniprot Identifier | P73_HUMAN | | Bait Gene Name | TP73 | | Sequence Position | 479-484 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Mutation analysis; Pull down; Co-IP | | Interaction ID | 21079 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15175157 | | Comments | The phosphorylation-dependent interaction between the WW domain of human Peptidyl-prolyl cis-trans isomerase PIN1 and Thr(482)-Pro motif in human Tumor protein TP73 is essential for activation of the apoptotic response by endogenous P73 |
Record No : 61 |
| Instance ID | 11097 | | Regular Expression | xxx([ST])Px | | Motif Instance | YQLSPP | | Bait Uniprot Accession | P03409 | | Bait Uniprot Identifier | TAX_HTL1A | | Bait Gene Name | tax | | Sequence Position | 157-162 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down | | Interaction ID | 21097 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19338781 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein by interacting with its phosphorylated Ser160-Pro motif and thereby promotes malignant transformation |
Record No : 62 |
| Instance ID | 11113 | | Regular Expression | xxx([ST])Px | | Motif Instance | ERITPL | | Bait Uniprot Accession | P54274 | | Bait Uniprot Identifier | TERF1_HUMAN | | Bait Gene Name | TERF1 | | Sequence Position | 146-151 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Co-IP; Pull down; Alanine scanning | | Interaction ID | 21113 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19060891 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Thr149–Pro motif in the human Telomeric protein Pin2/TRF1 in a phosphorylation-dependent and mitosis-specific manner and acts as an essential regulator of TRF1 stability, telomere maintenance and ageing |
Record No : 63 |
| Instance ID | 11117 | | Regular Expression | xxx([ST])Px | | Motif Instance | AAPTPA | | Bait Uniprot Accession | P04637 | | Bait Uniprot Identifier | P53_HUMAN | | Bait Gene Name | TP53 | | Sequence Position | 78-83 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Alanine scanning | | Interaction ID | 21117 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12397362 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-81-Pro motif of human Cellular tumor antigen TP53 and is involved in the regulation of its stability and transcriptional activities |
Record No : 64 |
| Instance ID | 11118 | | Regular Expression | xxx([ST])Px | | Motif Instance | TSSSPQ | | Bait Uniprot Accession | P04637 | | Bait Uniprot Identifier | P53_HUMAN | | Bait Gene Name | TP53 | | Sequence Position | 312-317 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Alanine scanning | | Interaction ID | 21118 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12397362 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Ser-315-Pro motif of human Cellular tumor antigen TP53 and is involved in the regulation of its stability and transcriptional activities |
Record No : 65 |
| Instance ID | 11160 | | Regular Expression | [LV][DE][^P][LM][LM][^P][^P]L[^P] | | Motif Instance | LDRLMASLS | | Bait Uniprot Accession | O43294 | | Bait Uniprot Identifier | TGFI1_HUMAN | | Bait Gene Name | TGFB1I1 | | Sequence Position | 158-166 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 21160 | | Interacting Domain | FAT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11463817 | | Comments | Human Hydrogen peroxide-inducible clone 5 (Hic-5) protein interacts with human Focal adhesion kinase 1 (FAK1/PTK2) through its LD motif |
Record No : 66 |
| Instance ID | 11215 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYPTDCSI | | Bait Uniprot Accession | Q9H3D4 | | Bait Uniprot Identifier | P63_HUMAN | | Bait Gene Name | TP63 | | Sequence Position | 540-549 | | Critical Residues | P1; P2; P4; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; CD; Fluorescence | | Interaction ID | 21215 | | Interacting Domain | WW domain | | Disease Association(s) | Hay-Wells syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Human E3 ubiquitin-protein ligase ITCH, a group I WW domain protein, and human Tumor protein TP63 interact with each other through the WW2 domain and the consensus PPxY or PY motif and this interaction is crucial for p63 degradation |
Record No : 67 |
| Instance ID | 11216 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYPTDCSI | | Bait Uniprot Accession | O88898 | | Bait Uniprot Identifier | P63_MOUSE | | Bait Gene Name | Tp63 | | Sequence Position | 540-549 | | Critical Residues | P1; P2; P4; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; CD; Fluorescence | | Interaction ID | 21216 | | Interacting Domain | WW domain | | Disease Association(s) | Hay-Wells syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Mouse E3 ubiquitin-protein ligase Itch, a group I WW domain protein, and mouse Tumor protein Tp63 interact with each other through the WW2 domain and the consensus PPxY or PY motif and this interaction is crucial for p63 degradation |
Record No : 68 |
| Instance ID | 11217 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYPTDCSI | | Bait Uniprot Accession | Q9JJP6 | | Bait Uniprot Identifier | P63_RAT | | Bait Gene Name | Tp63 | | Sequence Position | 540-549 | | Critical Residues | P1; P2; P4; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; CD; Fluorescence | | Interaction ID | 21217 | | Interacting Domain | WW domain | | Disease Association(s) | Hay-Wells syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Rat E3 ubiquitin-protein ligase Itch, a group I WW domain protein, and rat Tumor protein Tp63 interact with each other through the WW2 domain and the consensus PPxY or PY motif and this interaction is crucial for p63 degradation |
Record No : 69 |
| Instance ID | 11218 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYHADPSL | | Bait Uniprot Accession | O15350 | | Bait Uniprot Identifier | P73_HUMAN | | Bait Gene Name | TP73 | | Sequence Position | 484-493 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21218 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Human E3 ubiquitin-protein ligase ITCH, a group I WW domain protein, and human Tumor protein TP73 interact with each other through the WW2 domain and the consensus PPxY or PY motif |
Record No : 70 |
| Instance ID | 11219 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYHADPSL | | Bait Uniprot Accession | Q9JJP2 | | Bait Uniprot Identifier | P73_MOUSE | | Bait Gene Name | Tp73 | | Sequence Position | 478-487 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21219 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Mouse E3 ubiquitin-protein ligase Itch, a group I WW domain protein, and mouse Tumor protein Tp73 interact with each other through the WW2 domain and the consensus PPxY or PY motif |
Record No : 71 |
| Instance ID | 11220 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYHADPSL | | Bait Uniprot Accession | Q9XSK8 | | Bait Uniprot Identifier | P73_CHLAE | | Bait Gene Name | TP73 | | Sequence Position | 484-493 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21220 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Mouse E3 ubiquitin-protein ligase Itch, a group I WW domain protein, binds the Tumor protein P73 of African green monkey through the WW2 domain and the consensus PPxY or PY motif |
Record No : 72 |
| Instance ID | 11289 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | NIGIQTM | | Bait Uniprot Accession | Q12888 | | Bait Uniprot Identifier | TP53B_HUMAN | | Bait Gene Name | TP53BP1 | | Sequence Position | 1151-1157 | | Critical Residues | P3; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Mutational analysis | | Interaction ID | 21289 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15611139, 21533121 | | Comments | The LC8 dynein light chain binding motif (1151-1157) in human Tumor suppressor p53-binding protein 1 (TP53BP1) that binds to the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) and mediates DNA damage-induced p53 nuclear accumulation |
Record No : 73 |
| Instance ID | 11290 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | SAATQTI | | Bait Uniprot Accession | Q12888 | | Bait Uniprot Identifier | TP53B_HUMAN | | Bait Gene Name | TP53BP1 | | Sequence Position | 1168-1174 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Mutational analysis | | Interaction ID | 21290 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15611139, 21533121 | | Comments | The LC8 dynein light chain binding motif (1168-1174) in human Tumor suppressor p53-binding protein 1 (TP53BP1) that binds to the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) and mediates DNA damage-induced p53 nuclear accumulation |
Record No : 74 |
| Instance ID | 11330 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | DRSTQDE | | Bait Uniprot Accession | Q9UHF7 | | Bait Uniprot Identifier | TRPS1_HUMAN | | Bait Gene Name | TRPS1 | | Sequence Position | 1206-1212 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21330 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in human Zinc finger transcription factor TRPS1 that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 75 |
| Instance ID | 11331 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | DRSTQDE | | Bait Uniprot Accession | Q9UHF7 | | Bait Uniprot Identifier | TRPS1_HUMAN | | Bait Gene Name | TRPS1 | | Sequence Position | 1206-1212 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21331 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in human Zinc finger transcription factor TRPS1 that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 76 |
| Instance ID | 11358 | | Regular Expression | PxAxVxP | | Motif Instance | PTATVRP | | Bait Uniprot Accession | Q07912 | | Bait Uniprot Identifier | ACK1_HUMAN | | Bait Gene Name | TNK2 | | Sequence Position | 905-911 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis | | Interaction ID | 21358 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23208506 | | Comments | SIAH1-binding motif located in the far C-terminus of ACK1 |
Record No : 77 |
| Instance ID | 11359 | | Regular Expression | PxAxVxP | | Motif Instance | PTATVRP | | Bait Uniprot Accession | Q07912 | | Bait Uniprot Identifier | ACK1_HUMAN | | Bait Gene Name | TNK2 | | Sequence Position | 905-911 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis | | Interaction ID | 21359 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23208506 | | Comments | SIAH2-binding motif located in the far C-terminus of ACK1 |
Record No : 78 |
| Instance ID | 11445 | | Regular Expression | LxxLL | | Motif Instance | LTSLL | | Bait Uniprot Accession | Q64127 | | Bait Uniprot Identifier | TIF1A_MOUSE | | Bait Gene Name | Trim24 | | Sequence Position | 761-765 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21445 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8978696 | | Comments | Core LXXLL motif sequence in TRIM24 required for the ligand-dependent binding to Estrogen receptor |
Record No : 79 |
| Instance ID | 11446 | | Regular Expression | LxxLL | | Motif Instance | LTSLL | | Bait Uniprot Accession | Q64127 | | Bait Uniprot Identifier | TIF1A_MOUSE | | Bait Gene Name | Trim24 | | Sequence Position | 761-765 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21446 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8978696 | | Comments | Core LXXLL motif sequence in TRIM24 required for the ligand-dependent binding to Retinoic acid receptor |
Record No : 80 |
| Instance ID | 11447 | | Regular Expression | LxxLL | | Motif Instance | LTSLL | | Bait Uniprot Accession | Q64127 | | Bait Uniprot Identifier | TIF1A_MOUSE | | Bait Gene Name | Trim24 | | Sequence Position | 761-765 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21447 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8978696 | | Comments | Core LXXLL motif sequence in TRIM24 required for the ligand-dependent binding to Vitamin D3 receptor |
Record No : 81 |
| Instance ID | 11448 | | Regular Expression | LxxLL | | Motif Instance | LTSLL | | Bait Uniprot Accession | Q64127 | | Bait Uniprot Identifier | TIF1A_MOUSE | | Bait Gene Name | Trim24 | | Sequence Position | 761-765 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21448 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8978696 | | Comments | Core LXXLL motif sequence in TRIM24 required for the ligand-dependent binding to Progesterone receptor |
Record No : 82 |
| Instance ID | 11449 | | Regular Expression | LxxLL | | Motif Instance | LTSLL | | Bait Uniprot Accession | Q64127 | | Bait Uniprot Identifier | TIF1A_MOUSE | | Bait Gene Name | Trim24 | | Sequence Position | 761-765 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21449 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8978696 | | Comments | Core LXXLL motif sequence in TRIM24 required for the ligand-dependent binding to Retinoid X receptor |
Record No : 83 |
| Instance ID | 11480 | | Regular Expression | [VI]x[VI][VI] | | Motif Instance | IVDV | | Bait Uniprot Accession | O95551 | | Bait Uniprot Identifier | TYDP2_HUMAN | | Bait Gene Name | TDP2 | | Sequence Position | 280-283 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag); NMR | | Interaction ID | 21480 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16524884 | | Comments | The inverted SUMO-interacting Motif in human Tyrosyl-DNA phosphodiesterase 2 (TDP2) or TTRAP that directly interacts with human Small ubiquitin-related modifier 2 (SUMO2) |
Record No : 84 |
| Instance ID | 11481 | | Regular Expression | [VI]x[VI][VI] | | Motif Instance | IVDV | | Bait Uniprot Accession | O95551 | | Bait Uniprot Identifier | TYDP2_HUMAN | | Bait Gene Name | TDP2 | | Sequence Position | 280-283 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag); NMR | | Interaction ID | 21481 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16524884 | | Comments | The inverted SUMO-interacting Motif in human Tyrosyl-DNA phosphodiesterase 2 (TDP2) or TTRAP that directly interacts with human Small ubiquitin-related modifier 3 (SUMO3) |
Record No : 85 |
| Instance ID | 11482 | | Regular Expression | [VI]x[VI][VI] | | Motif Instance | IVDV | | Bait Uniprot Accession | O95551 | | Bait Uniprot Identifier | TYDP2_HUMAN | | Bait Gene Name | TDP2 | | Sequence Position | 280-283 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag); NMR | | Interaction ID | 21482 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16524884 | | Comments | The inverted SUMO-interacting Motif in human Tyrosyl-DNA phosphodiesterase 2 (TDP2) or TTRAP that directly interacts with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 86 |
| Instance ID | 11506 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P03409 | | Bait Uniprot Identifier | TAX_HTL1A | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR | | Interaction ID | 21506 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20842623 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) which binds to Human MAGI-1 |
Record No : 87 |
| Instance ID | 11507 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P14079 | | Bait Uniprot Identifier | TAX_HTL1C | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR | | Interaction ID | 21507 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20842623 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) which binds to Human MAGI-1 |
Record No : 88 |
| Instance ID | 11508 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P0C213 | | Bait Uniprot Identifier | TAX_HTL1F | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR | | Interaction ID | 21508 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20842623 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (isolate Zaire EL subtype B) (HTLV-1) which binds to Human MAGI-1 |
Record No : 89 |
| Instance ID | 11509 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P03409 | | Bait Uniprot Identifier | TAX_HTL1A | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Differential display analysis | | Interaction ID | 21509 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15003862 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) which binds to MAGI-3 in Rat-1 cells |
Record No : 90 |
| Instance ID | 11510 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P14079 | | Bait Uniprot Identifier | TAX_HTL1C | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Differential display analysis | | Interaction ID | 21510 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15003862 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) which binds to MAGI-3 in Rat-1 cells |
Record No : 91 |
| Instance ID | 11511 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P0C213 | | Bait Uniprot Identifier | TAX_HTL1F | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Differential display analysis | | Interaction ID | 21511 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15003862 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (isolate Zaire EL subtype B) (HTLV-1) which binds to MAGI-3 in Rat-1 cells |
Record No : 92 |
| Instance ID | 11514 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P03409 | | Bait Uniprot Identifier | TAX_HTL1A | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21514 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 9192623 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) that is likely to bind to hDLG/SAP97, the mammalian homolog for the Drosophila discs large tumor suppressor protein Dlg-A |
Record No : 93 |
| Instance ID | 11515 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P14079 | | Bait Uniprot Identifier | TAX_HTL1C | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21515 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 9192623 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) that is likely to bind to hDLG/SAP97, the mammalian homolog for the Drosophila discs large tumor suppressor protein Dlg-A |
Record No : 94 |
| Instance ID | 11516 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P0C213 | | Bait Uniprot Identifier | TAX_HTL1F | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21516 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 9192623 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (isolate Zaire EL subtype B) (HTLV-1) that is likely to bind to hDLG/SAP97, the mammalian homolog for the Drosophila discs large tumor suppressor protein Dlg-A |
Record No : 95 |
| Instance ID | 11533 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P03409 | | Bait Uniprot Identifier | TAX_HTL1A | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21533 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482110 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) which binds to Human TAX1BP3 |
Record No : 96 |
| Instance ID | 11534 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P14079 | | Bait Uniprot Identifier | TAX_HTL1C | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21534 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482110 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) which binds to Human TAX1BP3 |
Record No : 97 |
| Instance ID | 11535 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P0C213 | | Bait Uniprot Identifier | TAX_HTL1F | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21535 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482110 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (isolate Zaire EL subtype B) (HTLV-1) which binds to Human TAX1BP3 |
Record No : 98 |
| Instance ID | 11536 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P03409 | | Bait Uniprot Identifier | TAX_HTL1A | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21536 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482110 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) which binds to Human DLG4 |
Record No : 99 |
| Instance ID | 11537 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P14079 | | Bait Uniprot Identifier | TAX_HTL1C | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21537 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482110 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) which binds to Human DLG4 |
Record No : 100 |
| Instance ID | 11538 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P0C213 | | Bait Uniprot Identifier | TAX_HTL1F | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21538 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482110 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (isolate Zaire EL subtype B) (HTLV-1) which binds to Human DLG4 |
Record No : 101 |
| Instance ID | 11539 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P03409 | | Bait Uniprot Identifier | TAX_HTL1A | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21539 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482110 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) which binds to Human SNTB1 |
Record No : 102 |
| Instance ID | 11540 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P14079 | | Bait Uniprot Identifier | TAX_HTL1C | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21540 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482110 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) which binds to Human SNTB1 |
Record No : 103 |
| Instance ID | 11541 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P0C213 | | Bait Uniprot Identifier | TAX_HTL1F | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21541 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482110 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (isolate Zaire EL subtype B) (HTLV-1) which binds to Human SNTB1 |
Record No : 104 |
| Instance ID | 11542 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P03409 | | Bait Uniprot Identifier | TAX_HTL1A | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21542 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482110 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) which binds to Human GIPC1 |
Record No : 105 |
| Instance ID | 11543 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P14079 | | Bait Uniprot Identifier | TAX_HTL1C | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21543 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482110 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) which binds to Human GIPC1 |
Record No : 106 |
| Instance ID | 11544 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TEV | | Bait Uniprot Accession | P0C213 | | Bait Uniprot Identifier | TAX_HTL1F | | Bait Gene Name | tax | | Sequence Position | 351-353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21544 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482110 | | Comments | PDZ domain-binding motif in Tax1 oncoprotein of Human T-cell leukemia virus 1 (isolate Zaire EL subtype B) (HTLV-1) which binds to Human GIPC1 |
Record No : 107 |
| Instance ID | 11581 | | Regular Expression | [ST]x[VLI]$ | | Motif Instance | SDV | | Bait Uniprot Accession | Q13641 | | Bait Uniprot Identifier | TPBG_HUMAN | | Bait Gene Name | TPBG | | Sequence Position | 418-420 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21581 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11798178 | | Comments | Class I PDZ domain binding C-terminal motif in human 5T4 oncofetal trophoblast glycoprotein that is required for its interaction with PDZ domain-containing protein TIP-2/GIPC |
Record No : 108 |
| Instance ID | 11590 | | Regular Expression | [ST]x[VLI]$ | | Motif Instance | TDL | | Bait Uniprot Accession | O95049 | | Bait Uniprot Identifier | ZO3_HUMAN | | Bait Gene Name | TJP3 | | Sequence Position | 931-933 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21590 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12021270 | | Comments | The carboxyl terminus of ZO-3 (TJP3) that interacts with the 6th PDZ domain of PATJ (INADL) and is likely to be important for recruiting PATJ and its associated proteins to tight junctions |
Record No : 109 |
| Instance ID | 11657 | | Regular Expression | [ST]x[VLI] | | Motif Instance | STV | | Bait Uniprot Accession | P19334 | | Bait Uniprot Identifier | TRP_DROME | | Bait Gene Name | trp | | Sequence Position | 1264-1266 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Ser-P1 | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Ligand Overlay Assay | | Interaction ID | 21657 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8630257 | | Comments | Internal class I PDZ-domain binding motif in Drosophila Transient receptor potential protein (trp) that binds to PDZ 3 (the second PDZ domain) of Drosophila Inactivation-no-after-potential D protein (inaD) |
Record No : 110 |
| Instance ID | 11790 | | Regular Expression | FxLxP | | Motif Instance | FNLAP | | Bait Uniprot Accession | Q9BSI4 | | Bait Uniprot Identifier | TINF2_HUMAN | | Bait Gene Name | TINF2 | | Sequence Position | 258-262 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | X-ray crystallography; Mutational analysis; ITC | | Interaction ID | 21790 | | Interacting Domain | TRF1-TRFH domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18202258 | | Comments | The TRF1-TRFH binding motif in human TIN2 (TRF1-interacting nuclear protein 2) that interacts with the TRFH domain of human Telomeric repeat-binding factor 1 (TRF1) |
Record No : 111 |
| Instance ID | 11810 | | Regular Expression | [RK]x{0,1}[VIL][^P][FW] | | Motif Instance | RVKF | | Bait Uniprot Accession | Q13625 | | Bait Uniprot Identifier | ASPP2_HUMAN | | Bait Gene Name | TP53BP2 | | Sequence Position | 921-924 | | Critical Residues | P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Peptide binding assay; Peptide Competition Assay | | Interaction ID | 21810 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9155014, 8549741, 21998301 | | Comments | A short peptide from the PP1-binding protein p53BP2 (Tumor suppressor p53-binding protein 2) that contains the RVXF motif also interacts with protein phosphatase PP1-alpha catalytic subunit |
Record No : 112 |
| Instance ID | 11819 | | Regular Expression | Q[VI]CF | | Motif Instance | QVCF | | Bait Uniprot Accession | P04608 | | Bait Uniprot Identifier | TAT_HV1H2 | | Bait Gene Name | tat | | Sequence Position | 35-38 | | Critical Residues | P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21819 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16131488 | | Comments | Conserved Q[VI]CF sequence of Transactivating regulatory protein Tat found in among different HIV-1 isolates that participates in binding to human protein phosphatase PP1. Tat might function as a nuclear regulator of PP1 and interaction of Tat with PP1 is critical for activation of HIV-1 transcription by Tat |
Record No : 113 |
| Instance ID | 11837 | | Regular Expression | ISxPx{2,4}FxHxxHVGxD | | Motif Instance | ISQPLQNSFIHTGHGDSD | | Bait Uniprot Accession | Q07912 | | Bait Uniprot Identifier | ACK1_HUMAN | | Bait Gene Name | TNK2 | | Sequence Position | 454-471 | | Critical Residues | P1; P4; P9; P11; P14; P18 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; NMR; SPA | | Interaction ID | 21837 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10360579, 9601050, 7493928 | | Comments | The Cdc42/Rac interactive binding (CRIB) motif in human Activated CDC42 kinase 1 for binding to human CDC42 |
Record No : 114 |
| Instance ID | 11922 | | Regular Expression | [DE][DE][GL]W | | Motif Instance | DDGW | | Bait Uniprot Accession | P07996 | | Bait Uniprot Identifier | TSP1_HUMAN | | Bait Gene Name | THBS1 | | Sequence Position | 379-382 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; SPOT Analysis | | Interaction ID | 21922 | | Interacting Domain | Alpha M I domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12824186 | | Comments | A negatively charged peptide motif within the catalytic domain of Thrombospondin-1 that mediates binding to Integrin alpha-M of leukocytes |
Record No : 115 |
| Instance ID | 12030 | | Regular Expression | x[DEKR]x[ACVILFM]$ | | Motif Instance | AGHM | | Bait Uniprot Accession | P15923 | | Bait Uniprot Identifier | TFE2_HUMAN | | Bait Gene Name | TCF3 | | Sequence Position | 651-654 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | ELISA; Pull down | | Interaction ID | 22030 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25009770 | | Comments | The carboxy-terminal PDZ binding motif of human Transcription factor E2-alpha/ Transcription factor 3 (TCF3) that interacts with the human 26S proteasome non-ATPase regulatory subunit 9 (PSMD9) |
Record No : 116 |
| Instance ID | 12031 | | Regular Expression | Qxx[ILM]xx[FHY][FHY] | | Motif Instance | QEKITDTF | | Bait Uniprot Accession | Q13569 | | Bait Uniprot Identifier | TDG_HUMAN | | Bait Gene Name | TDG | | Sequence Position | 95-102 | | Critical Residues | P1; P4; P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22031 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24962565 | | Comments | The eight amino acid PCNA-binding motif in human Thymine-DNA glycosylase (TDG) that mediates its interaction with human Proliferating cell nuclear antigen (PCNA) and leads to targeting of TDG to the CRL4(Cdt2) E3 ubiquitin ligase complex |
Record No : 117 |
| Instance ID | 12148 | | Regular Expression | GWGQT | | Motif Instance | GWGQT | | Bait Uniprot Accession | Q8NDV7 | | Bait Uniprot Identifier | TNR6A_HUMAN | | Bait Gene Name | TNRC6A | | Sequence Position | 722-726 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22148 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23150874 | | Comments | The Ago-interacting motif [GW-I:722-726] in human Trinucleotide repeat-containing gene 6A protein (TNRC6A) that mediates binding to human Argonaute-2 (AGO2) |
Record No : 118 |
| Instance ID | 12149 | | Regular Expression | GWEEPSP | | Motif Instance | GWEEPSP | | Bait Uniprot Accession | Q8NDV7 | | Bait Uniprot Identifier | TNR6A_HUMAN | | Bait Gene Name | TNRC6A | | Sequence Position | 986-992 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22149 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23150874 | | Comments | The Ago-interacting motif [GW-II:986-992] in human Trinucleotide repeat-containing gene 6A protein (TNRC6A) that mediates binding to human Argonaute-2 (AGO2) |
Record No : 119 |
| Instance ID | 12191 | | Regular Expression | ([KR][^ED]{0,5}[ST]xIP[^ED]{5,5})|([^ED]{5,5}[ST]xIP[^ED]{0,5}[KR]) | | Motif Instance | KPSKIPVYTKR | | Bait Uniprot Accession | Q4U9M9 | | Bait Uniprot Identifier | 104K_THEAN | | Bait Gene Name | TA08425 | | Sequence Position | 564-574 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22191 | | Interacting Domain | EBH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23675298 | | Comments | The C-terminal EBH domain of mouse End-binding protein 1 (EB1) or Mapre1 binds to the SxIP motif of 104 kDa microneme/rhoptry antigen (p104) of Theileria annulata, a tick-borne Apicomplexan parasite |
|
