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Total : 18 Records
Record No : 1 |
| Instance ID | 10088 | | Regular Expression | [R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI] | | Motif Instance | RDALLGDIRKGMKLKKA | | Bait Uniprot Accession | P37370 | | Bait Uniprot Identifier | VRP1_YEAST | | Bait Gene Name | VRP1 | | Sequence Position | 31-47 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Classical fluorescence spectroscopy; Y2H; Mutation analysis; GFP tag | | Interaction ID | 20088 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9412475 | | Comments | WH2 motif in Yeast verprolin, encoded by VRP1, that binds to the hydrophobic cleft formed by subdomains 1 and 3 of Yeast Actin, thus allowing Verprolin to serve as a polarity development protein, perhaps by anchoring actin |
Record No : 2 |
| Instance ID | 10429 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | FPPPP | | Bait Uniprot Accession | P12003 | | Bait Uniprot Identifier | VINC_CHICK | | Bait Gene Name | VCL | | Sequence Position | 842-846 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Far Western blotting | | Interaction ID | 20429 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8980130 | | Comments | Proline-rich motif within chicken Vinculin that is required for its interaction with VASP |
Record No : 3 |
| Instance ID | 10718 | | Regular Expression | xP[TS]APx | | Motif Instance | LPTAPP | | Bait Uniprot Accession | Q05128 | | Bait Uniprot Identifier | VP40_EBOZM | | Bait Gene Name | VP40 | | Sequence Position | 6-11 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20718 | | Interacting Domain | UEV domain | | Disease Association(s) | Ebola virus infection | | Inhibitor(s) | Unknown | | Reference(s) | 12525615 | | Comments | The UEV Domain binding P[TS]AP motif in Membrane-associated Matrix protein VP40 of Zaire Ebola virus that mediates binding to the UEV domain of human Tumor susceptibility gene 101 protein (TSG101) |
Record No : 4 |
| Instance ID | 10724 | | Regular Expression | xP[TS]APx | | Motif Instance | APTAPL | | Bait Uniprot Accession | Q9H9H4 | | Bait Uniprot Identifier | VP37B_HUMAN | | Bait Gene Name | VPS37B | | Sequence Position | 184-189 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20724 | | Interacting Domain | UEV domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15218037 | | Comments | The UEV Domain binding P[TS]AP motif in Human ESCRT-I complex subunit VPS37B that mediates binding to the UEV domain of human ESCRT-I complex subunit TSG101 |
Record No : 5 |
| Instance ID | 10811 | | Regular Expression | RGD | | Motif Instance | RGD | | Bait Uniprot Accession | P29788 | | Bait Uniprot Identifier | VTNC_MOUSE | | Bait Gene Name | Vtn | | Sequence Position | 64-66 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20811 | | Interacting Domain | FG-GAP repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1703206 | | Comments | The Integrin binding RGD motif in mouse Vitronectin (Vtn) that mediates binding to the mouse Vitronectin receptor subunit alpha/Integrin alpha-V (Itgav) |
Record No : 6 |
| Instance ID | 10841 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGNES | | Bait Uniprot Accession | P05923 | | Bait Uniprot Identifier | VPU_HV1BR | | Bait Gene Name | vpu | | Sequence Position | 51-56 | | Critical Residues | P2 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Radiolabel; Confocal microscopy | | Interaction ID | 20841 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Human immunodeficiency virus (HIV) infection | | Inhibitor(s) | Unknown | | Reference(s) | 14674748, 14561767 | | Comments | Phosphorylation of the HIV-1 protein Vpu at Ser52 and Ser56 within the DSGXXS motif is required for its interaction with the SCF-betaTrCP ubiquitin ligase complex, which triggers HIV receptor CD4 degradation by the proteasome |
Record No : 7 |
| Instance ID | 10954 | | Regular Expression | [ED][LIV]NNN[^P] | | Motif Instance | DINNNN | | Bait Uniprot Accession | P09052 | | Bait Uniprot Identifier | VASA1_DROME | | Bait Gene Name | vas | | Sequence Position | 184-189 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20954 | | Interacting Domain | SPRY domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20561531 | | Comments | Substrate recognition site for the SPRY domain of the Drosophila protein gustavus (gus) identified in Drosophila DEAD-box RNA helicase vasa |
Record No : 8 |
| Instance ID | 10955 | | Regular Expression | [ED][LIV]NNN[^P] | | Motif Instance | DINNNN | | Bait Uniprot Accession | P09052 | | Bait Uniprot Identifier | VASA1_DROME | | Bait Gene Name | vas | | Sequence Position | 184-189 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20955 | | Interacting Domain | SPRY domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20561531 | | Comments | Substrate recognition site for the SPRY domain of human SPRY domain-containing SOCS box protein 1 (SPSB1) identified in Drosophila DEAD-box RNA helicase vasa |
Record No : 9 |
| Instance ID | 11056 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P35260 | | Bait Uniprot Identifier | VP40_MABVM | | Bait Gene Name | VP40 | | Sequence Position | 16-19 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Confocal microscopy; Pull down; Mutation analysis | | Interaction ID | 21056 | | Interacting Domain | WW domain | | Disease Association(s) | Marburg virus disease (MVD) | | Inhibitor(s) | Unknown | | Reference(s) | 19812267 | | Comments | The PY motif of the VP40 matrix protein of Marburg virus (MARV) that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4 |
Record No : 10 |
| Instance ID | 11057 | | Regular Expression | PPxY | | Motif Instance | PPEY | | Bait Uniprot Accession | Q05128 | | Bait Uniprot Identifier | VP40_EBOZM | | Bait Gene Name | VP40 | | Sequence Position | 10-13 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Ubiquitinase assay; Western blot; Mutation analysis | | Interaction ID | 21057 | | Interacting Domain | WW domain | | Disease Association(s) | Ebola virus infection | | Inhibitor(s) | Unknown | | Reference(s) | 11095724 | | Comments | The PPxY motif within the Membrane-associated Matrix protein VP40 of Ebola virus interacts physically and functionally with mouse E3 ubiquitin-protein ligase Nedd4 |
Record No : 11 |
| Instance ID | 11185 | | Regular Expression | NGR | | Motif Instance | NGR | | Bait Uniprot Accession | P03135 | | Bait Uniprot Identifier | CAPSD_AAV2S | | Bait Gene Name | VP1 | | Sequence Position | 511-513 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Far Western blotting; Western blot; Co-IP | | Interaction ID | 21185 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9883843 | | Comments | The NGR motif within the Capsid protein VP1 of Adeno-associated virus 2 (AAV-2) that directly associates with the beta5 subunit (ITGB5) of human alphaVbeta5 integrin |
Record No : 12 |
| Instance ID | 11186 | | Regular Expression | NGR | | Motif Instance | NGR | | Bait Uniprot Accession | P03135 | | Bait Uniprot Identifier | CAPSD_AAV2S | | Bait Gene Name | VP1 | | Sequence Position | 511-513 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Competition binding | | Interaction ID | 21186 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16940508 | | Comments | The NGR motif within the Capsid protein VP1 of Adeno-associated virus 2 (AAV-2) that directly associates with the beta1 subunit (ITGB1) of human alpha5beta1 integrin |
Record No : 13 |
| Instance ID | 11206 | | Regular Expression | WxP | | Motif Instance | WHP | | Bait Uniprot Accession | F5H9D8 | | Bait Uniprot Identifier | F5H9D8_HHV8 | | Bait Gene Name | vIRF-4 | | Sequence Position | 471-473 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Hybridization of peptide arrays; Y2H; Competition binding assay | | Interaction ID | 21206 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Kaposi's sarcoma | | Inhibitor(s) | Unknown | | Reference(s) | 20861242 | | Comments | Short peptide motif in VIRF-4 protein of Human herpesvirus 8 through which it targets the hydrophobic pocket in the beta trefoil domain of CSL/CBF1 (RBPJ) |
Record No : 14 |
| Instance ID | 11336 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | NSQTQTD | | Bait Uniprot Accession | Q05127 | | Bait Uniprot Identifier | VP35_EBOZM | | Bait Gene Name | VP35 | | Sequence Position | 70-76 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21336 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in Polymerase cofactor VP35 of Zaire Ebola virus that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 15 |
| Instance ID | 11337 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | NSQTQTD | | Bait Uniprot Accession | Q05127 | | Bait Uniprot Identifier | VP35_EBOZM | | Bait Gene Name | VP35 | | Sequence Position | 70-76 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21337 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in Polymerase cofactor VP35 of Zaire Ebola virus that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 16 |
| Instance ID | 12052 | | Regular Expression | [DE][DE][ILVM]Yx | | Motif Instance | DDLYG | | Bait Uniprot Accession | Q01853 | | Bait Uniprot Identifier | TERA_MOUSE | | Bait Gene Name | Vcp | | Sequence Position | 802-806 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; ITC | | Interaction ID | 22052 | | Interacting Domain | PUB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17496150 | | Comments | The c-terminal cofactor-binding motif of mouse Transitional endoplasmic reticulum ATPase p97 subunit (VCP) that is both necessary and sufficient to mediate its interactions with mouse Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) |
Record No : 17 |
| Instance ID | 12053 | | Regular Expression | [DE][DE][ILVM]Yx | | Motif Instance | DDLYG | | Bait Uniprot Accession | P55072 | | Bait Uniprot Identifier | TERA_HUMAN | | Bait Gene Name | VCP | | Sequence Position | 802-806 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; ITC; Pull down(GST tag) | | Interaction ID | 22053 | | Interacting Domain | PUB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24726327 | | Comments | The c-terminal PUB interacting motif (PIM) of human Transitional endoplasmic reticulum ATPase (VCP) that binds to the PUB domain of human E3 ubiquitin-protein ligase RNF31/HOIP |
Record No : 18 |
| Instance ID | 12167 | | Regular Expression | Rx{0,3}AxAAxxR | | Motif Instance | RARAAEER | | Bait Uniprot Accession | Q04311 | | Bait Uniprot Identifier | VMS1_YEAST | | Bait Gene Name | VMS1 | | Sequence Position | 620-627 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22167 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21070972 | | Comments | The VCP-interacting motif (VIM) in yeast VCP/CDC48-associated mitochondrial stress-responsive protein 1 (Vms1) that mediates interaction with the yeast Cell division control protein 48 (Cdc48/VCP) |
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