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Total : 47 Records
Record No : 1 |
| Instance ID | 10013 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSHSSP | | Bait Uniprot Accession | Q9EPK5 | | Bait Uniprot Identifier | WWTR1_MOUSE | | Bait Gene Name | Wwtr1 | | Sequence Position | 86-91 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis | | Interaction ID | 20013 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11118213 | | Comments | 14-3-3 binding motif in WW domain-containing transcription regulator protein 1 that binds 14-3-3 protein zeta |
Record No : 2 |
| Instance ID | 10093 | | Regular Expression | [R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI] | | Motif Instance | RGALLDQIRQGIQLNKT | | Bait Uniprot Accession | P42768 | | Bait Uniprot Identifier | WASP_HUMAN | | Bait Gene Name | WAS | | Sequence Position | 431-447 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Fluorescence polarization spectroscopy; ITC; circular dichroism; X-ray crystallography; structure based prediction; Sequence based prediction | | Interaction ID | 20093 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11146629, 16275905 | | Comments | WH2 motif in human Wiskott-Aldrich syndrome protein that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 3 |
| Instance ID | 10094 | | Regular Expression | [R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI] | | Motif Instance | RSVLLEAIRKGIQLRKV | | Bait Uniprot Accession | Q92558 | | Bait Uniprot Identifier | WASF1_HUMAN | | Bait Gene Name | WASF1 | | Sequence Position | 498-514 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Fluorescence polarization spectroscopy; ITC; circular dichroism; NMR | | Interaction ID | 20094 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11146629, 16403731 | | Comments | WH2 motif in human protein WAVE-1 that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 4 |
| Instance ID | 10095 | | Regular Expression | [R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI] | | Motif Instance | RSVLLEAIRKGIQLRKV | | Bait Uniprot Accession | Q92558 | | Bait Uniprot Identifier | WASF1_HUMAN | | Bait Gene Name | WASF1 | | Sequence Position | 498-514 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Fluorescence polarization spectroscopy; ITC; circular dichroism; NMR | | Interaction ID | 20095 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11146629, 16403731 | | Comments | WH2 motif in human protein WAVE-1 that binds to the hydrophobic cleft formed by subdomains 1 and 3 of Acanthamoeba Actin-1 |
Record No : 5 |
| Instance ID | 10096 | | Regular Expression | [R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI] | | Motif Instance | RNALLSDISKGKKLKKT | | Bait Uniprot Accession | O43516 | | Bait Uniprot Identifier | WIPF1_HUMAN | | Bait Gene Name | WIPF1 | | Sequence Position | 33-49 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; ITC; structure based prediction; Sequence based prediction | | Interaction ID | 20096 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16275905 | | Comments | WH2 motif in human WASP-interacting protein that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 6 |
| Instance ID | 10097 | | Regular Expression | [R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI] | | Motif Instance | RSDLLSAIRQGFQLRRV | | Bait Uniprot Accession | Q9Y6W5 | | Bait Uniprot Identifier | WASF2_HUMAN | | Bait Gene Name | WASF2 | | Sequence Position | 437-453 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; ITC; structure based prediction; Sequence based prediction | | Interaction ID | 20097 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16275905 | | Comments | WH2 motif in human protein WAVE-2 that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 7 |
| Instance ID | 10206 | | Regular Expression | ^M{0,1}Ax[AP]x | | Motif Instance | MAVPF | | Bait Uniprot Accession | Q24106 | | Bait Uniprot Identifier | HID_DROME | | Bait Gene Name | W | | Sequence Position | 1-5 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20206 | | Interacting Domain | BIR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11511363 | | Comments | IAP-binding motif in Drosophila Cell death protein W or Hid that binds to the BIR2 domain of Drosophila Iap2 (dIAP2) |
Record No : 8 |
| Instance ID | 10451 | | Regular Expression | [FY]x[FW]xxxxx[LMVIF]PxP[DE] | | Motif Instance | YSFHPVEDFPAPE | | Bait Uniprot Accession | Q8TF74 | | Bait Uniprot Identifier | WIPF2_HUMAN | | Bait Gene Name | WIPF2 | | Sequence Position | 400-412 | | Critical Residues | P1; P3; P8; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Alanine scanning | | Interaction ID | 20451 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15265696, 12213210 | | Comments | The EVH1 class III motif found in the human verprolin homologue WIRE (WIPF2) that participates in binding to human Wiskott-Aldrich syndrome protein (WASP) |
Record No : 9 |
| Instance ID | 10452 | | Regular Expression | [FY]x[FW]xxxxx[LMVIF]PxP[DE] | | Motif Instance | FTFHSMEDFPPPD | | Bait Uniprot Accession | Q9Z0G8 | | Bait Uniprot Identifier | WIPF3_RAT | | Bait Gene Name | Wipf3 | | Sequence Position | 425-437 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Classical fluorescence spectroscopy; AP-MS; Pull down | | Interaction ID | 20452 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11553796 | | Comments | The EVH1 class III motif found in the rat Corticosteroids and regional expression protein 16 (Cr16 or Wipf3) that participates in binding to bovine Neuronal Wiskott-Aldrich syndrome protein (N-WASP) |
Record No : 10 |
| Instance ID | 10453 | | Regular Expression | [FY]x[FW]xxxxx[LMVIF]PxP[DE] | | Motif Instance | FYFHPISDLPPPE | | Bait Uniprot Accession | O43516 | | Bait Uniprot Identifier | WIPF1_HUMAN | | Bait Gene Name | WIPF1 | | Sequence Position | 454-466 | | Critical Residues | P1; P3; P8; P9; P12 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; NMR; Mutation analysis; structure based prediction; Alanine scanning; GFP tag; Pull down | | Interaction ID | 20453 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12437929, 17229736, 12372256 | | Comments | The rat N-WASP EVH1 domain specifically binds an EVH1 class III motif from the human WASP Interacting Protein (WIP or WIPF1) |
Record No : 11 |
| Instance ID | 10654 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | PFLTWL | | Bait Uniprot Accession | Q9EPK5 | | Bait Uniprot Identifier | WWTR1_MOUSE | | Bait Gene Name | Wwtr1 | | Sequence Position | 390-395 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis | | Interaction ID | 20654 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11118213 | | Comments | C-terminal class 1 PDZ-binding motif in mouse Transcriptional coactivator with PDZ-binding motif (Taz) that binds to the PDZ domain of mouse Na(+)/H(+) exchange regulatory cofactor Nherf2/ NHE3 kinase A regulatory protein E3KARP (Slc9a3r2) |
Record No : 12 |
| Instance ID | 10898 | | Regular Expression | xxx[PV]xxP | | Motif Instance | FVSPTPP | | Bait Uniprot Accession | Q8R5H6 | | Bait Uniprot Identifier | WASF1_MOUSE | | Bait Gene Name | Wasf1 | | Sequence Position | 319-325 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag) | | Interaction ID | 20898 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10970852 | | Comments | Mouse Wave1/Wasf1, a Wiskott-Aldrich syndrome protein, binds to the SH3 domain of the mouse Proto-oncogene c-Abl/Abelson tyrosine kinase (Abl) |
Record No : 13 |
| Instance ID | 10931 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFQVT | | Bait Uniprot Accession | Q80UE6 | | Bait Uniprot Identifier | WNK4_MOUSE | | Bait Gene Name | Wnk4 | | Sequence Position | 996-1000 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20931 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15930150 | | Comments | Volume sensitivity of cation-chloride cotransporters is modulated by functional interaction between the conserved C-terminal (CCT) domain of mouse Ste20-related kinase Stk39/Spak and the RFxV docking motif of mouse Serine/threonine-protein kinase Wnk4 |
Record No : 14 |
| Instance ID | 10935 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFIVS | | Bait Uniprot Accession | Q9H4A3 | | Bait Uniprot Identifier | WNK1_HUMAN | | Bait Gene Name | WNK1 | | Sequence Position | 1257-1261 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20935 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16263722 | | Comments | The human Serine/threonine-protein kinase WNK1 was found to bind strongly to mouse Oxidative stress-responsive 1 protein (Oxsr1/Osr1) through its RFxV docking motif (1257-1261) |
Record No : 15 |
| Instance ID | 10936 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFQVT | | Bait Uniprot Accession | Q9H4A3 | | Bait Uniprot Identifier | WNK1_HUMAN | | Bait Gene Name | WNK1 | | Sequence Position | 1945-1949 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20936 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16263722 | | Comments | The human Serine/threonine-protein kinase WNK1 was found to bind strongly to mouse Oxidative stress-responsive 1 protein (Oxsr1/Osr1) through its RFxV docking motif (1945-1949) |
Record No : 16 |
| Instance ID | 10937 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFQVS | | Bait Uniprot Accession | Q9H4A3 | | Bait Uniprot Identifier | WNK1_HUMAN | | Bait Gene Name | WNK1 | | Sequence Position | 1859-1863 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20937 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16263722 | | Comments | The human Serine/threonine-protein kinase WNK1 was found to bind strongly to mouse Oxidative stress-responsive 1 protein (Oxsr1/Osr1) through its RFxV docking motif (1859-1863) |
Record No : 17 |
| Instance ID | 10938 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFSVS | | Bait Uniprot Accession | Q9H4A3 | | Bait Uniprot Identifier | WNK1_HUMAN | | Bait Gene Name | WNK1 | | Sequence Position | 1957-1961 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20938 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16263722 | | Comments | The human Serine/threonine-protein kinase WNK1 was found to bind strongly to mouse Oxidative stress-responsive 1 protein (Oxsr1/Osr1) through its RFxV docking motif (1957-1961) |
Record No : 18 |
| Instance ID | 10939 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFIVS | | Bait Uniprot Accession | Q9H4A3 | | Bait Uniprot Identifier | WNK1_HUMAN | | Bait Gene Name | WNK1 | | Sequence Position | 1257-1261 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20939 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16263722 | | Comments | The human Serine/threonine-protein kinase WNK1 was found to bind strongly to rat stress-related kinase Stk39/Spak through its RFxV docking motif (1257-1261) |
Record No : 19 |
| Instance ID | 10940 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFQVT | | Bait Uniprot Accession | Q9H4A3 | | Bait Uniprot Identifier | WNK1_HUMAN | | Bait Gene Name | WNK1 | | Sequence Position | 1945-1949 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20940 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16263722 | | Comments | The human Serine/threonine-protein kinase WNK1 was found to bind strongly to rat stress-related kinase Stk39/Spak through its RFxV docking motif (1945-1949) |
Record No : 20 |
| Instance ID | 10941 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFQVS | | Bait Uniprot Accession | Q9H4A3 | | Bait Uniprot Identifier | WNK1_HUMAN | | Bait Gene Name | WNK1 | | Sequence Position | 1859-1863 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20941 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16263722 | | Comments | The human Serine/threonine-protein kinase WNK1 was found to bind strongly to rat stress-related kinase Stk39/Spak through its RFxV docking motif (1859-1863) |
Record No : 21 |
| Instance ID | 10942 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFSVS | | Bait Uniprot Accession | Q9H4A3 | | Bait Uniprot Identifier | WNK1_HUMAN | | Bait Gene Name | WNK1 | | Sequence Position | 1957-1961 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20942 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16263722 | | Comments | The human Serine/threonine-protein kinase WNK1 was found to bind strongly to rat stress-related kinase Stk39/Spak through its RFxV docking motif (1957-1961) |
Record No : 22 |
| Instance ID | 10943 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFQVT | | Bait Uniprot Accession | Q96J92 | | Bait Uniprot Identifier | WNK4_HUMAN | | Bait Gene Name | WNK4 | | Sequence Position | 1016-1020 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR; X-ray crystallography; Mutation analysis | | Interaction ID | 20943 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Pseudohypoaldosteronism type 2 (PHA2) | | Inhibitor(s) | Unknown | | Reference(s) | 17721439 | | Comments | Human Serine/threonine-protein kinase WNK4 interacts with the conserved C-terminal (CCT) domain of human Oxidative stress-responsive 1 protein (OXSR1) through its RFxV docking motif |
Record No : 23 |
| Instance ID | 11049 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P97764 | | Bait Uniprot Identifier | WBP1_MOUSE | | Bait Gene Name | Wbp1 | | Sequence Position | 173-176 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 21049 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7644498 | | Comments | The PY motif of mouse WW domain-binding protein 1 (Wbp1) binds with relatively high affinity and specificity to the WW domain of mouse Yes-associated protein (Yap1/Yap65) |
Record No : 24 |
| Instance ID | 11137 | | Regular Expression | xxx([ST])Px | | Motif Instance | NPFTPD | | Bait Uniprot Accession | Q8QGV2 | | Bait Uniprot Identifier | WEE1B_XENLA | | Bait Gene Name | wee1-b | | Sequence Position | 183-188 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Pull down; Alanine scanning | | Interaction ID | 21137 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17360425 | | Comments | Prolyl isomerase Pin1 from Xenopus laevis specifically binds the phosphorylated Thr-186-Pro motif of Xenopus Zygotic wee1-like protein kinase 1B, the inhibitory kinase of cyclin B/Cdc2, for its catalytic inactivation at M phase of the mitotic cell cycle |
Record No : 25 |
| Instance ID | 11584 | | Regular Expression | [ST]x[VLI]$ | | Motif Instance | TWL | | Bait Uniprot Accession | Q9EPK5 | | Bait Uniprot Identifier | WWTR1_MOUSE | | Bait Gene Name | Wwtr1 | | Sequence Position | 393-395 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21584 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20850437 | | Comments | The carboxy-terminal PDZ binding motif of mouse WW domain-containing transcription regulator protein 1 (or Taz) that interacts with the Canis PDZ domain of Tight junction protein ZO-2 |
Record No : 26 |
| Instance ID | 11585 | | Regular Expression | [ST]x[VLI]$ | | Motif Instance | TWL | | Bait Uniprot Accession | Q9EPK5 | | Bait Uniprot Identifier | WWTR1_MOUSE | | Bait Gene Name | Wwtr1 | | Sequence Position | 393-395 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21585 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20850437 | | Comments | The carboxy-terminal PDZ binding motif of mouse WW domain-containing transcription regulator protein 1 (or Taz) that interacts with the Canis PDZ domain of Tight junction protein ZO-2 |
Record No : 27 |
| Instance ID | 11586 | | Regular Expression | [ST]x[VLI]$ | | Motif Instance | TWL | | Bait Uniprot Accession | Q9EPK5 | | Bait Uniprot Identifier | WWTR1_MOUSE | | Bait Gene Name | Wwtr1 | | Sequence Position | 393-395 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21586 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20850437 | | Comments | The carboxy-terminal PDZ binding motif of mouse WW domain-containing transcription regulator protein 1 (or Taz) that interacts with the human PDZ domain of Tight junction protein ZO-1 |
Record No : 28 |
| Instance ID | 11587 | | Regular Expression | [ST]x[VLI]$ | | Motif Instance | TWL | | Bait Uniprot Accession | Q9EPK5 | | Bait Uniprot Identifier | WWTR1_MOUSE | | Bait Gene Name | Wwtr1 | | Sequence Position | 393-395 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21587 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20850437 | | Comments | The carboxy-terminal PDZ binding motif of mouse WW domain-containing transcription regulator protein 1 (or Taz) that interacts with the human PDZ domain of Tight junction protein ZO-2 |
Record No : 29 |
| Instance ID | 11588 | | Regular Expression | [ST]x[VLI]$ | | Motif Instance | TWL | | Bait Uniprot Accession | Q9GZV5 | | Bait Uniprot Identifier | WWTR1_HUMAN | | Bait Gene Name | WWTR1 | | Sequence Position | 398-400 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21588 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20850437 | | Comments | The carboxy-terminal PDZ binding motif of human WW domain-containing transcription regulator protein 1 (or TAZ) that interacts with the human PDZ domain of Tight junction protein ZO-2 |
Record No : 30 |
| Instance ID | 11589 | | Regular Expression | [ST]x[VLI]$ | | Motif Instance | TWL | | Bait Uniprot Accession | Q9GZV5 | | Bait Uniprot Identifier | WWTR1_HUMAN | | Bait Gene Name | WWTR1 | | Sequence Position | 398-400 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21589 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20850437 | | Comments | The carboxy-terminal PDZ binding motif of human WW domain-containing transcription regulator protein 1 (or TAZ) that interacts with the human PDZ domain of Tight junction protein ZO-1 |
Record No : 31 |
| Instance ID | 11591 | | Regular Expression | [DE]x[VLI]$ | | Motif Instance | DDV | | Bait Uniprot Accession | Q8IX03 | | Bait Uniprot Identifier | KIBRA_HUMAN | | Bait Gene Name | WWC1 | | Sequence Position | 1110-1113 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Y2H | | Interaction ID | 21591 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18596123 | | Comments | The C-terminal motif of KIBRA (WWC1) that directly interacts with the eighth PDZ domain of PATJ (INADL) |
Record No : 32 |
| Instance ID | 11655 | | Regular Expression | [ST]x[RK] | | Motif Instance | SVK | | Bait Uniprot Accession | Q8IX03 | | Bait Uniprot Identifier | KIBRA_HUMAN | | Bait Gene Name | WWC1 | | Sequence Position | 975-977 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Ser-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide phosphorylation assay | | Interaction ID | 21655 | | Interacting Domain | Catalytic domain of PKC-zeta | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15081397 | | Comments | PKC phosphorylation site (975-977) of KIBRA (WWC1) for binding to the catalytic domain of Protein kinase C zeta type |
Record No : 33 |
| Instance ID | 11656 | | Regular Expression | [ST]x[RK] | | Motif Instance | SLR | | Bait Uniprot Accession | Q8IX03 | | Bait Uniprot Identifier | KIBRA_HUMAN | | Bait Gene Name | WWC1 | | Sequence Position | 978-980 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Ser-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide phosphorylation assay | | Interaction ID | 21656 | | Interacting Domain | Catalytic domain of PKC-zeta | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15081397 | | Comments | PKC phosphorylation site (978-980) of KIBRA (WWC1) for binding to the catalytic domain of Protein kinase C zeta type |
Record No : 34 |
| Instance ID | 11836 | | Regular Expression | ISxPx{2,4}FxHxxHVGxD | | Motif Instance | IGAPSGFKHVSHVGWD | | Bait Uniprot Accession | P42768 | | Bait Uniprot Identifier | WASP_HUMAN | | Bait Gene Name | WAS | | Sequence Position | 238-253 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; NMR; GDI assay | | Interaction ID | 21836 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8805223, 9660763, 10360578, 9601050, 7493928 | | Comments | The Cdc42/Rac interactive binding (CRIB) motif of the Wiskott Aldrich syndrome protein that forms a minimal consensus for binding to human CDC42 and is necessary but not sufficient for tight binding |
Record No : 35 |
| Instance ID | 11847 | | Regular Expression | PPG[WFYML] | | Motif Instance | PPGL | | Bait Uniprot Accession | Q9Y2W2 | | Bait Uniprot Identifier | WBP11_HUMAN | | Bait Gene Name | WBP11 | | Sequence Position | 475-478 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21847 | | Interacting Domain | GYF domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16000308 | | Comments | Proline-rich sequences (475-478) in human Npw38-binding protein that serves as a recognition motif for the GYF domain of the cellular adapter protein CD2BP2 |
Record No : 36 |
| Instance ID | 11848 | | Regular Expression | PPG[WFYML] | | Motif Instance | PPGL | | Bait Uniprot Accession | Q9Y2W2 | | Bait Uniprot Identifier | WBP11_HUMAN | | Bait Gene Name | WBP11 | | Sequence Position | 519-522 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21848 | | Interacting Domain | GYF domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16000308 | | Comments | Proline-rich sequences (519-522) in human Npw38-binding protein that serves as a recognition motif for the GYF domain of the cellular adapter protein CD2BP2 |
Record No : 37 |
| Instance ID | 11983 | | Regular Expression | PPLP | | Motif Instance | PPLP | | Bait Uniprot Accession | Q92558 | | Bait Uniprot Identifier | WASF1_HUMAN | | Bait Gene Name | WASF1 | | Sequence Position | 430-433 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | PAX-MS | | Interaction ID | 21983 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22606326 | | Comments | PPLP motif in human WAVE1 (WASF1) recognized by the group II WW domain of GAS7 |
Record No : 38 |
| Instance ID | 11991 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P97765 | | Bait Uniprot Identifier | WBP2_MOUSE | | Bait Gene Name | Wbp2 | | Sequence Position | 197-200 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21991 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7644498 | | Comments | The PY motif (197-200) of mouse WW domain-binding protein 2 (Wbp2) that binds to the WW domain of mouse Yes-associated protein (Yap1/Yap65) |
Record No : 39 |
| Instance ID | 11992 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P97765 | | Bait Uniprot Identifier | WBP2_MOUSE | | Bait Gene Name | Wbp2 | | Sequence Position | 249-252 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21992 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7644498 | | Comments | The PY motif (249-252) of mouse WW domain-binding protein 2 (Wbp2) that binds to the WW domain of mouse Yes-associated protein (Yap1/Yap65) |
Record No : 40 |
| Instance ID | 12172 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LSCDE | | Bait Uniprot Accession | K7WGV9 | | Bait Uniprot Identifier | K7WGV9_9VIRU | | Bait Gene Name | wssv_00560 | | Sequence Position | 216-220 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22172 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24027329 | | Comments | The conserved LxCxE motif in Wsv056 protein of White spot syndrome virus (WSSV), a major pathogen of shrimp, that mediates binding to the Retinoblastoma family-like protein (RBL) of Litopenaeus vannamei (Whiteleg shrimp) |
Record No : 41 |
| Instance ID | 12173 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LSCDE | | Bait Uniprot Accession | K7WGV9 | | Bait Uniprot Identifier | K7WGV9_9VIRU | | Bait Gene Name | wssv_00560 | | Sequence Position | 216-220 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22173 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24027329 | | Comments | The conserved LxCxE motif in Wsv056 protein of White spot syndrome virus (WSSV) that mediates binding to the Transcription factor E2f2 of Drosophila melanogaster |
Record No : 42 |
| Instance ID | 12206 | | Regular Expression | (Rx{1,3}PPGPPP)|(PPGPPPx{1,3}R)|(Rx{1,3}PPGPPPx{1,3}R) | | Motif Instance | RKPPGPPP | | Bait Uniprot Accession | Q9Y2W2 | | Bait Uniprot Identifier | WBP11_HUMAN | | Bait Gene Name | WBP11 | | Sequence Position | 197-204 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPOT Analysis; Pull down(GST tag); Y2H; Co-IP | | Interaction ID | 22206 | | Interacting Domain | WW domain | | Disease Association(s) | Golabi-Ito-Hall syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 10593949, 20410308 | | Comments | Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 (polyglutamine tract-binding protein 1 or Npw38) affects its binding to WBP-11 (WW domain-binding protein 11 or NpwBP) via a novel proline-rich motif (197-204) and deregulates pre-mRNA splicing |
Record No : 43 |
| Instance ID | 12207 | | Regular Expression | (Rx{1,3}PPGPPP)|(PPGPPPx{1,3}R)|(Rx{1,3}PPGPPPx{1,3}R) | | Motif Instance | RLLPPGPPPGR | | Bait Uniprot Accession | Q9Y2W2 | | Bait Uniprot Identifier | WBP11_HUMAN | | Bait Gene Name | WBP11 | | Sequence Position | 456-466 | | Critical Residues | P1; P11 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPOT Analysis; Pull down(GST tag); Y2H; Co-IP | | Interaction ID | 22207 | | Interacting Domain | WW domain | | Disease Association(s) | Golabi-Ito-Hall syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 10593949, 20410308 | | Comments | Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 (polyglutamine tract-binding protein 1 or Npw38) affects its binding to WBP-11 (WW domain-binding protein 11 or NpwBP) via a novel proline-rich motif (456-466) and deregulates pre-mRNA splicing |
Record No : 44 |
| Instance ID | 12208 | | Regular Expression | xPPRx | | Motif Instance | PPPRG | | Bait Uniprot Accession | Q9Y2W2 | | Bait Uniprot Identifier | WBP11_HUMAN | | Bait Gene Name | WBP11 | | Sequence Position | 482-486 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; ITC; Pull down | | Interaction ID | 22208 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19592703 | | Comments | The PPR motif in human splicing factor SIPP1 or WBP11 which mediates its interaction with the WW domains of human FBP21 or WBP4 |
Record No : 45 |
| Instance ID | 12209 | | Regular Expression | xPPRx | | Motif Instance | PPPRG | | Bait Uniprot Accession | Q923D5 | | Bait Uniprot Identifier | WBP11_MOUSE | | Bait Gene Name | Wbp11 | | Sequence Position | 482-486 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide library screening; Pull down(GST tag) | | Interaction ID | 22209 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10744724 | | Comments | The PPR motif in mouse splicing factor SIPP1 or WBP11 which mediates its interaction with the WW domains of mouse FBP21 or WBP4 |
Record No : 46 |
| Instance ID | 12214 | | Regular Expression | [ILMV]xxx[ILMVF]xx[ILMVA][ILMVA]x[KR]Rxx[ILMVA] | | Motif Instance | IENDVATILSRRIAV | | Bait Uniprot Accession | Q92558 | | Bait Uniprot Identifier | WASF1_HUMAN | | Bait Gene Name | WASF1 | | Sequence Position | 527-541 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutational analysis; Y2H; Co-IP; GST fusion protein binding assay | | Interaction ID | 22214 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12872157, 9889097 | | Comments | The conserved sequence motif that forms an amphipathic helix in the C-terminus VCA region of human WASF1 (also known as SCAR1/WAVE1) and mediates interaction with the p21 subunit (CDKN1A) of the Arp2/3 complex |
Record No : 47 |
| Instance ID | 12215 | | Regular Expression | [ILMV]xxx[ILMVF]xx[ILMVA][ILMVA]x[KR]Rxx[ILMVA] | | Motif Instance | LVGALMHVMQKRSRA | | Bait Uniprot Accession | P42768 | | Bait Uniprot Identifier | WASP_HUMAN | | Bait Gene Name | WAS | | Sequence Position | 466-480 | | Critical Residues | P12 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | NMR; Spectrofluorometric affinity titration assay; GST-affinity assay | | Interaction ID | 22215 | | Interacting Domain | GTPase binding domain | | Disease Association(s) | X-linked severe congenital neutropenia | | Inhibitor(s) | Unknown | | Reference(s) | 10724160, 11242115 | | Comments | The autoinhibitory intramolecular interaction between the GTPase-binding domain and the carboxy-terminal region of human Wiskott-Aldrich syndrome protein that occlude residues of the C terminus which regulate the Arp2/3 actin-nucleating complex |
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