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Total : 12 Records
Record No : 1 |
| Instance ID | 10441 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | LPLPP | | Bait Uniprot Accession | Q702N8 | | Bait Uniprot Identifier | XIRP1_HUMAN | | Bait Gene Name | XIRP1 | | Sequence Position | 22-26 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Dot blot; Y2H | | Interaction ID | 20441 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16631741 | | Comments | Proline-rich motif present in human Xin, the protein encoded by the human gene ‘cardiomyopathy associated 1’ (CMYA1), that is required for its interaction with VASP |
Record No : 2 |
| Instance ID | 10442 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | LPLPP | | Bait Uniprot Accession | Q702N8 | | Bait Uniprot Identifier | XIRP1_HUMAN | | Bait Gene Name | XIRP1 | | Sequence Position | 22-26 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20442 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16631741 | | Comments | Proline-rich motif present in human Xin, the protein encoded by the human gene ‘cardiomyopathy associated 1’ (CMYA1), that is required for its interaction with ENAH |
Record No : 3 |
| Instance ID | 10443 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | LPLPP | | Bait Uniprot Accession | Q702N8 | | Bait Uniprot Identifier | XIRP1_HUMAN | | Bait Gene Name | XIRP1 | | Sequence Position | 22-26 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20443 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16631741 | | Comments | Proline-rich motif present in human Xin, the protein encoded by the human gene ‘cardiomyopathy associated 1’ (CMYA1), that is required for its interaction with EVL |
Record No : 4 |
| Instance ID | 10469 | | Regular Expression | P[MVLIRWY]V[MVLIAS][LM] | | Motif Instance | PLVLL | | Bait Uniprot Accession | P12956 | | Bait Uniprot Identifier | XRCC6_HUMAN | | Bait Gene Name | XRCC6 | | Sequence Position | 352-356 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Co-IP; Pull down(GST tag) | | Interaction ID | 20469 | | Interacting Domain | Chromo shadow domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11112778 | | Comments | Human Ku70 (DNA repair protein XRCC6) interacts with heterochromatin protein 1alpha (HP1 alpha/CBX5) using a HP1-binding motif that interacts with an interface formed by dimerization of two chromoshadow domains in HP1 |
Record No : 5 |
| Instance ID | 10691 | | Regular Expression | [DEN][DEN]x{2,3}[ILMVA][DEN][DEN]L | | Motif Instance | EEGGDVDDL | | Bait Uniprot Accession | P13010 | | Bait Uniprot Identifier | XRCC5_HUMAN | | Bait Gene Name | XRCC5 | | Sequence Position | 720-728 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP | | Interaction ID | 20691 | | Interacting Domain | HEAT repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15758953 | | Comments | Conserved carboxy-terminal motif in human DNA repair protein XRCC5 (Ku80) that is required for its interaction with human DNA-dependent protein kinase catalytic subunit (PRKDC) |
Record No : 6 |
| Instance ID | 11102 | | Regular Expression | xxx([ST])Px | | Motif Instance | SSPSPS | | Bait Uniprot Accession | P69713 | | Bait Uniprot Identifier | X_HBVA3 | | Bait Gene Name | X | | Sequence Position | 38-43 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Co-IP; Pull down(GST tag) | | Interaction ID | 21102 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17383430 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the Ser-41-Pro motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis |
Record No : 7 |
| Instance ID | 11169 | | Regular Expression | xx(T)xx[DE]x | | Motif Instance | ESTDEES | | Bait Uniprot Accession | Q13426 | | Bait Uniprot Identifier | XRCC4_HUMAN | | Bait Gene Name | XRCC4 | | Sequence Position | 231-237 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag); ITC; Fluorescence polarization spectroscopy | | Interaction ID | 21169 | | Interacting Domain | FHA domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15385968 | | Comments | Human Bifunctional polynucleotide phosphatase/kinase PNKP functions in Nonhomologous end joining (NHEJ) via an FHA domain-dependent interaction with a phosphothreonine motif of human DNA repair protein XRCC4 |
Record No : 8 |
| Instance ID | 11171 | | Regular Expression | xx(T)xx[DE]x | | Motif Instance | GSTDEES | | Bait Uniprot Accession | Q924T3 | | Bait Uniprot Identifier | XRCC4_MOUSE | | Bait Gene Name | Xrcc4 | | Sequence Position | 229-235 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21171 | | Interacting Domain | FHA domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15749016 | | Comments | Mouse Bifunctional polynucleotide phosphatase/kinase Pnkp is recruited to repair complexes through interactions between its N-terminal FHA domain and a phosphorylated threonine residue (T231) in mouse DNA repair protein Xrcc4 |
Record No : 9 |
| Instance ID | 11174 | | Regular Expression | xx(T)xx[DE]x | | Motif Instance | ENTDSEE | | Bait Uniprot Accession | P18887 | | Bait Uniprot Identifier | XRCC1_HUMAN | | Bait Gene Name | XRCC1 | | Sequence Position | 521-527 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence polarization spectroscopy; Mutation analysis | | Interaction ID | 21174 | | Interacting Domain | FHA domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15367657 | | Comments | The FHA domain of human Bifunctional polynucleotide phosphatase/kinase PNKP binds to a phosphothreonine motif (T523) from human DNA repair protein XRCC1 |
Record No : 10 |
| Instance ID | 11232 | | Regular Expression | [ST]x[VL]D | | Motif Instance | SSLD | | Bait Uniprot Accession | Q13426 | | Bait Uniprot Identifier | XRCC4_HUMAN | | Bait Gene Name | XRCC4 | | Sequence Position | 259-262 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21232 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22876914 | | Comments | Novel internal motif identified in human DNA repair protein XRCC4 that is recognized by human Glutaminase-interacting protein (GIP), also known as Tax-interacting protein 1 (TIP1) or Tax1-binding protein 3 (TAX1BP3), composed almost exclusively of a single PDZ domain |
Record No : 11 |
| Instance ID | 12035 | | Regular Expression | WxxLxxxL | | Motif Instance | WKLLAKGL | | Bait Uniprot Accession | Q01831 | | Bait Uniprot Identifier | XPC_HUMAN | | Bait Gene Name | XPC | | Sequence Position | 848-855 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 22035 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16627479, 17897675 | | Comments | The WxxLxxxL centrin-binding motif in human Xeroderma pigmentosum group C-complementing protein (XPC) that binds to Human Centrin-2 (CETN2) |
Record No : 12 |
| Instance ID | 12145 | | Regular Expression | xxx[PV]xxP | | Motif Instance | GLPPPPP | | Bait Uniprot Accession | O70373 | | Bait Uniprot Identifier | XIRP1_MOUSE | | Bait Gene Name | Xirp1 | | Sequence Position | 32-38 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Pull down(GST tag) | | Interaction ID | 22145 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23296090 | | Comments | The predicted SH3-binding motif in the N-terminal region of mouse Xin actin-binding repeat-containing protein 1 (Xirp1) that interacts with mouse cortactin |
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